Product: Polydatin
Ⅰ,Introduction to polydatin
Polydatin is Polygonum cuspidatum root of Polygonaceae; Polygonum multiflorum root; Picea spruce bark of Pinaceae; Eucalyptus of Myrtaceae family, etc. Mainly derived from the dried rhizomes and roots of Polygonum cuspidatum Sieb. et Zucc. Polydatin is one of the natural active ingredients. It is white needle-like crystalline powder. Easily soluble in methanol, ethanol, ethyl acetate, slightly soluble in water.
Ⅱ,Functions and indications of polydatin
Antitussive, phlegm-removing, asthma-relieving, antibacterial, scavenging free radicals, regulating blood lipids, lowering cholesterol. Antibacterial effect: It has inhibitory effect on Staphylococcus aureus, Coccus catarrhalis, Streptococcus A or B, Escherichia coli, etc.
1. Polydatin has the functions of dispelling wind and dampness, dispersing blood stasis, relieving pain, relieving cough and reducing phlegm, etc.; it is mainly used for joint pain, damp-heat jaundice, amenorrhea, abscesses, burns from water and fire, bruises, carbuncles and sores, Cough with lots of phlegm.
2. It has the effects of strengthening the heart and dilating blood vessels, inhibiting platelet aggregation, regulating blood lipids, relieving cough and asthma, dispelling wind and dampness, dissipating blood stasis, anti-virus, and anti-tumor.
3. Polydatin has a strong antibacterial effect on the crimson Trichophyton and interdigital Trichophyton that cause stubborn ringworm and sweat vesicles.
4. In clinical application, its extract has a significant antibacterial effect on clinically pathogenic fungi, and its compound also has a significant hepatoprotective effect.
Ⅲ,Pharmacological effects of polydatin
Improve microcirculation, inhibit the release of lysosomal enzymes, antioxidant, prevent leukocyte adhesion in microcirculation, lower blood lipids, resist lipid peroxidation, resist pathogenic microorganisms, antitussive, antiasthmatic, antibacterial, antiviral, hepatoprotective, etc. effect. The drug polydatin injection can treat cardiovascular and cerebrovascular diseases such as myocardial ischemia, cerebral ischemia, and shock.
1.1. Effect on cardiovascular system
1) Effect on cardiomyocytes
Studies on rat cardiomyocytes through PD have shown that its cardiotonic effect may directly increase myocardial contractility by increasing the concentration of free calcium ions in individual cells; it may also have the function of enhancing calcium pumps or Na + -Ca2 + exchange proteins. This allows the Ca2+ in the cytoplasm during diastole to be taken back into the sarcoplasmic reticulum or discharged out of the cell faster and more effectively. This effect of PD makes it theoretically superior to digitalis cardiotonic glycosides in cardiac function. It not only makes myocardial contraction more powerful, but also makes myocardial relaxation more complete, thus greatly improving myocardial function.
Work efficiency.
2) Effect on vascular smooth muscle cells (VSMC)
Studies on the effects of PD on rat blood smooth muscle cells and human umbilical cord artery smooth muscle cells show that PD has a bidirectional regulatory effect on intracellular calcium and pH. Under normal circumstances, PD not only promotes the entry of extracellular calcium ions into the cells of VSMC, but also induces the release of intracellular calcium, increasing intracellular calcium levels; at the same time, it increases pH to increase vascular tone. During shock, it reduces intracellular calcium concentration and intracellular pH to reduce vascular tension and dilate blood vessels; it can regulate blood vessels by promoting the influx of extracellular sodium ions and using cell depolarization. Its effect may be related to the opening of sodium and potassium channels. And it is reversely regulated by β-adrenergic receptors, H2 receptor system and guanylyl cyclase system.
3) Anti-platelet aggregation effect
Studies have found that PD inhibits platelet aggregation induced by arachidonic acid (AA) and adenosine diphosphate (ADP) both in vivo and in vitro; the effect of PD on platelet aggregation and thromboxane B2 in rabbits was measured using turbidimetric method and radioimmunoassay. (TXB2), it was confirmed that PD6.7 ~ 107.2μmol/L can significantly inhibit AA and ADP-induced rabbit platelet aggregation and TXB2 production. The inhibition rates were 48% ~ 90% and 43% ~ 69% respectively. The inhibition of TXB2 production The rates were 50% ~ 78% and 43% ~ 68% respectively. There was a significant positive correlation between the two inhibition rates; the study also confirmed that PD can also inhibit the aggregation of human platelets. Its main route is through the prostate system. Inhibiting platelet aggregation induced by AA and ADP mainly inhibits cyclooxygenase and reduces thromboxane A2 (TXA2); inhibiting platelet aggregation induced by thrombin may also inhibit platelet aggregation induced by thrombin, in addition to inhibiting cyclooxygenase, and may also increase prostacyclin (PGI2). related to the release.
Ⅳ,Clinical application of polydatin
The specific link of cell signaling that polydatin acts in cells provides theoretical guidance for the clinical prevention and treatment of shock, the development of new drugs and the study of shock mechanism.
Ⅴ,The difference between polydatin and resveratrol is
Polydatin is hydrolyzed to resveratrol. Polydatin is more easily absorbed by the body than resveratrol. Polydatin is basically not synthesized, but resveratrol is synthesized. The knotweed plant contains polydatin but no resveratrol. Resveratrol is obtained through acidolysis or enzymatic hydrolysis.
1.Resveratrol is a natural antioxidant that can reduce blood viscosity, inhibit platelet coagulation and vasodilation, keep blood flowing, prevent the occurrence and development of cancer, and resist atherosclerosis and coronary heart disease. Preventive and therapeutic effects on ischemic heart disease and hyperlipidemia.It has anti-atherosclerosis and prevention and treatment effects on coronary heart disease, ischemic heart disease and hyperlipidemia. It can delay aging and prevent cancer. It is found in red grape skins, red wine and grape juice. Studies have shown that the integrity of chromosomes will be destroyed as humans age, and resveratrol can activate sirtuin, a protein that repairs chromosome health, thereby delaying aging.
Polydatin improves microcirculation, inhibits the release of lysosomal enzymes, is antioxidant, prevents leukocyte adhesion in microcirculation, lowers blood lipids, resists lipid peroxidation, resists pathogenic microorganisms, is antitussive and asthmatic, antibacterial, antiviral, and protects health. Liver and other functions.
2.Polydatin can be converted into resveratrol after being taken by the human body
3.Resveratrol: Molecular formula: C14H12O3 Molecular weight: 228 CAS: 501-36-0
Polydatin: Molecular formula: C20H22O8 Molecular weight: 390.40 CAS: 65914-17-2
In terms of name, the Chinese alias of resveratrol is also called polydatin, and the alias of polydatin is also called resveratrol glycoside.
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