Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of 6-paradol in China. With abundant experience, we warmly welcome you to wholesale bulk 6-paradol for sale here from our factory. Quality products and reasonable price are available.
Product Description
6-Paradol is one of the primary active constituents of ginger. It possesses a pungent taste and a chemical structure similar to capsaicin, while exhibiting various biological activities such as anti-inflammatory and immune-enhancing effects.
With 12 years of deep expertise in plant extracts and functional ingredients, YTBIO is dedicated to providing global clients with high-quality raw materials and one-stop customized services. We offer 6-Paradol in both 50% powder and 98% liquid forms, and support free samples as well as flexible minimum order quantities.
|
Item |
Details |
|
Product Name |
6-paradol |
|
Molecular Formula |
C₁₇H₂₆O₃ |
|
CAS No. |
27113-22-0 |
|
Specification |
50% powder,98%liquid |
|
Appearance |
White powder |
Conforms |
|
Identification |
HPLC |
Conforms |
|
Heavy metal |
≤0.001% |
Conforms |
|
Water Content |
≤1.0% |
0.29% |
|
Assay |
50.0 |
52.3% |
Functions
1. 6-Paradol promotes gastrointestinal motility and gastric juice secretion, helping to alleviate symptoms such as indigestion, nausea, and vomiting.
2. It can lower blood pressure and blood lipid levels, reduce the incidence of atherosclerosis, and provide cardiovascular protection.
3. It enhances the body's immune function and disease resistance, aiding in the prevention and treatment of immune-related disorders.
4. It possesses sedative and analgesic properties, helping to improve symptoms associated with nervous system disorders.
Anti-obesity Effects and Homeostatic Regulation
A study investigated the anti-obesity effects and homeostatic regulatory role of 6-paradol in vivo. By comparing it with structurally similar vanilloid compounds-specifically 6-gingerol and 6-shogaol-researchers examined the physiological effects and the impact on genes related to fat metabolism in the adipose tissue and liver of mice with high-fat diet-induced obesity.
Sufficient quantities of the aforementioned vanilloid compounds were synthesized for animal experiments, involving oral administration to 6-week-old male mice over a two-week period. The results showed that 6-paradol reduced weight gain as well as visceral and subcutaneous fat accumulation in the mice within the two-week timeframe, whereas 6-gingerol and 6-shogaol did not produce these effects.
Furthermore, 6-paradol suppressed hepatic cholesterol and triglyceride levels and significantly downregulated the expression of genes associated with fatty acid synthesis, lipid transport, and adipocyte differentiation in both the liver and adipose tissue. Notably, while 6-gingerol significantly promoted the phosphorylation of AMP-activated protein kinase (AMPK)-a key regulator of lipid metabolism-6 paradol did not exhibit this effect.
Source: Hattori H, Mori T, Shibata T, Kita M, Mitsunaga T. 6-Paradol Acts as a Potential Anti-obesity Vanilloid from Grains of Paradise. Mol Nutr Food Res. 2021 Aug;65(16):e2100185. doi: 10.1002/mnfr.202100185. Epub 2021 Jun 30. PMID: 33793045.
Key Applications
1. Serves as an organic synthesis intermediate for pharmaceutical development and research.
2. Attracts interest in the fields of sports nutrition and antioxidants; shows promise for weight management applications; characterized by low irritation and a lack of side effects.
Preparation Method
A method for preparing 6-Paradol comprises the following steps:
1. Preparation of the enone intermediate
Mix the raw materials-vanillin, 2-nonanone, and N,N-dimethylformamide-and react at 60°C–100°C. Monitor the reaction via liquid chromatography; stop the reaction when the content of the raw material 2-nonanone falls below 0.2%. Then, add an aqueous solution of glacial acetic acid, stir while cooling to room temperature, filter, wash with water, and dry to obtain the enone intermediate.
2. Preparation of 6-paradol
Charge a reaction flask with metallic sodium, anhydrous sodium acetate, and tetrahydrofuran. Under a nitrogen atmosphere, add the enone intermediate (dissolved in ethanol) to the flask. Upon completion of the reaction, decolorize with activated carbon, filter, and recover the solvent to obtain a pale yellow oily substance: 6-paradol.
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