Tablet OEM/ODM

A tablet (also known as a pill) is a pharmaceutical oral dosage form (oral solid dosage, or OSD) or solid unit dosage form. It comprises a mixture of active substances and excipients, usually in powder form, that are pressed or compacted into a solid dose. Tablets are prepared either by moulding or by compression. The excipients can include diluents, binders or granulating agents, glidants (flow aids) and lubricants to ensure efficient tabletting; disintegrants to promote tablet break-up in the digestive tract; sweeteners or flavours to enhance taste; and pigments to make the tablets visually attractive or aid in visual identification of an unknown tablet.

Tablet Pros
● Inexpensive. Although it depends on the active ingredient and the casing, tablets are generally cheaper to manufacture than capsules. This often makes them more affordable for consumers.
● Durable and Long-Lasting. Tablets are more stable and typically have a longer shelf life than capsules.
● Higher Dosages. A single tablet can accommodate a higher dose of an active ingredient than a single capsule.
● Can be Split. Unlike capsules, tablets can be cut in two for a smaller dose, if needed.
● Chewable. Some tablets are available in chewable or even orally-dissolving tablet forms.
● Variable Delivery. Tablets can come in quick release, delayed release, or extended release formats.

Tablet Cons
● More Likely to Cause Irritation. Tablets are more likely to irritate the gastrointestinal tract.
● Slower Acting. Once in the body, tablets are absorbed more slowly than capsules. They may take longer to work.
● Uneven Disintegration. Tablets are more likely to break down inconsistently, which can decrease the medication’s effectiveness and overall absorption.
● Less Palatable. While many tablets have a flavored coating to mask the taste of the medication, some do not. Once swallowed, they can leave a bad aftertaste.

Dry Granulation
Roller compaction (also referred to as roll compaction) is a common dry granulation technology which is especially well-suited for heat- and moisture-sensitive actives. Dry granulation (DG) incorporates mechanical compression either by slugging or roller compaction while wet granulation (WG) uses a liquid and typically a binder to facilitate agglomeration of the powder particles.
Forming granules without liquid using the DG technique requires compacting the mix followed by size reduction of the compacts to the desired particle size. DG can be used to improve flow properties and prevent segregation of components in cases where DC processes reach their limits, and to avoid API degradation induced by WG. Because it does not use moisture, DG is especially well-suited for APIs that are sensitive to solvents or moisture. Compared to wet granulation, DG is a shorter, more cost-effective manufacturing process.
DG can be performed in two ways – slugging or roller compaction. With slugging, tableting presses are used to form large tablets (slugs) which are then broken by a hammer mill to form granules. In roller compaction, the raw material is compressed into plates or sheets between two rotating rollers, which are then milled into granules. Compared to slugging, roller compaction is very gentle, making it the preferred approach with heat- and moisture-sensitive materials.
Another benefit of using a roller compactor is that the auger-feed system delivers the powder materials consistently between the two rollers. In contrast, poor flow properties of the material may result in various degrees of densification of the compacts produced using table press compaction.

Wet Granulation
In WG, a liquid and typically a binder is used to granulate the powder and the process requires blending, wetting, wet mass stage, drying, and sizing. The binder is typically a polymer such as polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), copovidone, starch or cellulose derivatives dissolved in either an aqueous or organic solvent.
While aqueous solutions are eco-friendly and relatively less expensive than organic solvents, they can have a longer drying time. Examples of organic solvents used in WG are ethanol and propanol.
Several approaches to WG are available:
● High-Shear processes use equipment that mixes the powder and liquid using high shear forces, accelerating the manufacturing process.
● Twin-Screw granulation continuously manufactures wet granulate powders at lower liquid concentrations and with improved product consistency.
● Fluid bed granulation is a multiple-Step WG process in which the powders are pre-heated, granulated, and dried in the same vessel. This technique allows close control of the granulation process.
As noted above, among the most widely used binders are PVA, PVP, copovidone, starch, and cellulose derivatives; commonly used fillers in oral dosage forms include lactose, microcrystalline cellulose (MCC), calcium phosphates, and mannitol.

Continuous Manufacturing
All of these tableting technologies can be either applied in traditional, stepwise, batch manufacturing or as part of a continuous manufacturing process. It is important that the individual components show good flowability to support feed and throughput which.
Overall, continuous manufacturing offers several advantages compared to batch manufacturing including:
● Improved efficiency with a single, end-to-end process operating in one location
● Elimination of the need for scale-up to larger equipment
● Reduced risk of human error with the use of in-process controls
● Reduced manual handling and less time needed for equipment cleaning

Tablets or Capsules that Need to be Swallowed Whole
(1)Wash your hands.
(2)Remove the required number of tablets or capsules from the packaging and put in a plastic cup.
(3)Put one on tongue towards the back of mouth.
(4)Give your a drink from a cup without a spout or nozzle.
(5)The tablet or capsule should be swallowed along with the drink. It might help to look down while swallowing.
(6)Repeat with the rest of the dose if necessary.

Tablets or Capsules that Can Be Crushed or Emptied
(1)Wash your hands.
(2)Remove the required number of tablets or capsules from the packaging and put in a plastic cup.
(3)For tablets – Put the tablet in the tablet crusher and empty the crushed tablet back into the plastic cup.
(4)For capsules – Hold the capsule over the plastic cup and gently pull the two halves apart so the contents fall into the plastic cup.
(5)Mix the crushed tablet or capsule contents with a small amount of water as instructed on the label, making sure they are well mixed.
(6)Draw up the mixture in an oral syringe and give to as instructed on the label.
(7)Give a drink to wash down the medicine.

Note: Instead of mixing with water, you can also mix the crushed tablet or capsule contents with a teaspoon of yoghurt.

Giving a Proportion of a Tablet That Can be Dispersed
(1)Measure a specific volume of water, for example 10ml or as instructed on the label.
(2)Disperse the tablet(s) in the water – do not stir or shake the mixture.
(3)Draw up the required proportion using an oral syringe following the instructions on the label.
(4)Give the required dose.
Note: Use a new tablet or capsule each time unless otherwise directed.

Storing the Tablets or Capsules Safely
(1)Keep all medicines out of the reach and sight of children.
(2)Keep the tablets or capsules in their original packaging in a cool, dark place according to the instructions on the label.
(3)Read the instructions on the label and only use the tablets or capsules.
(4)Always check the expiry date of the medicine.

Dosage Form Selection
Selecting a suitable dosage form based on the characteristics of raw materials, consumer habits, and the convenience of delivery is very important for the tablet dosage form. Here are a few different types of commonly seen dosage forms of tablet manufacturing——glass-bottle drinks, glass-bottle carbonated drinks, back side seal powder sachets, powder pouch, easy-to-carry liquid sachet, 25ml PET liquid concentrated drink, tablets, capsules, functional jelly, etc. The product designer will integrate your needs and propose a tablet development proposal that matches your brand values and carry out tablet ODM product development.

Formula Manufacturing
Tablet formulation manufacturing is a science. The first requirement is safety. Even if the raw material is very popular, it will not be added as long as there is any doubt. tablet formulation manufacture is not as simple as A+B+C. We must consider whether the raw materials will have cross-reactions and Maillard reactions. For example, phenols and proteins will produce precipitation. The poor water solubility of raw materials causes precipitation, powder formulations tend to absorb moisture and caking or discoloration. To avoid these problems, everything must be designed by professionals. In addition, we must pay attention to the scientific nature of tablet formulation manufacture. The correct estimation of the number of effective ingredients added is to ensure the effectiveness of the product during the validity period.

Providing Samples
Tablet manufacturer researchers will provide samples during this stage. Sampling after formulation confirmation is an important step before mass production. This stage confirms that the product is correctly standardized, has the same quality before mass production for production evaluation, and turns various ideas into reality. The powder particle size of powder sachets and density will affect filling and sealing. Taste is an important aspect of the customer experience as well. Drink tablet ODM product mixes various flavours in different ratios to propose a flavour that is acceptable for the target customer of the private label tablets.

Quality Assurance
We provide production records and implements layers of inspection on raw materials and finished goods. Our professional legal team provides global regulatory consultation, import, and export planning, intellectual property protection, and patent placement, allowing customers to focus more on marketing without worrying about rapid market expansion and sales in new regions.

Stability Testing
The test items selected should be based on the ingredients, product characteristics, quality requirements, and items that are susceptible to change during the storage period of the product and may have an impact on its quality, safety, or efficacy. If the health effects of the ingredients (or quality control indicators) of the product have been identified, this should be used as the test item.

After-Sales Support
The only way to achieve a win-win situation is for consumers to benefit and tablet companies to profit. tablet ODMs not only manufacture the products for the brands, but also give multiple added value services to accelerate product promotion through product planning, marketing, and professional lecturer support.