The Source of Aloe Emodin
Aloe vera (L.) Burm. f.) is a plant of the lily family. Perennial, evergreen, stems very short above ground; Leaves are thick and succulent, narrow lanceolate, base broad pink green, margin spiny denticle; Flowers with yellow or red spots; The fruit is triangular in shape; Flowering occurs in late winter. Aloe vera's "Lu" word is the meaning of black, and the "hui" word is the meaning of gathering, aloe vera because its leaves are cut, the liquid dripping down the incision, will be black from the coffee color, slowly condensed, so the name "aloe Vera".
Aloe Vera is cultivated in South Africa, Madagascar, Arabian Peninsula, southeast China, South China, Southwest and other places, and can occasionally see wild aloe vera distribution. Aloe vera, commonly cultivated in China, produces fewer flowers and fruits. Aloe enjoys warm, dry and sunny conditions, is not cold tolerant, drought tolerant and semi-shade tolerant. It is suitable for fertile, loose and well-drained soil cultivation, it is commonly used to divide forest and interbreeding method.
"Traditional Chinese Medicine" records that aloe honey local smear can prevent chemotherapeutic phlebitis, reduce vascular intimal damage, has the effect of draining heat and guiding stagnation, eliminating malnutrition and killing insects, clearing heat and cooling liver, and is a common product for draining liver fire and eliminating malnutrition. Aloe vera can be used to make high-quality cosmetics, health drugs, etc., its products are well-known in South Korea, and promoted to the international market, becoming one of the main pillar industries of the national economy of South Korea, aloe vera was recommended by the Food and Agriculture Organization of the United Nations as "the best health food in the 21st century".
Aloe Emodin Introduction
Aloe emodin is one of the main components of aloe essential oil. It exists in aloe as a free state or as a glycosome in Rhubarb, senna and aloe. The precipitated from toluene or ethanol is an orange-yellow acicular crystal. Molecular weight 270.25. Melting point 223 ~ 224℃. Sublimation in the carbon dioxide stream. Soluble in hot ethanol, ether, benzene, the solution is yellow, but also soluble in ammonia solution and sulfuric acid, the solution is crimson.
Aloe vera's main active ingredients are aloin and aloe emodin. Aloe vera juice has anti-inflammatory, anti-inflammatory and healing effects on damaged skin. Aloe emodin can inhibit cholesterol absorption, and it can effectively promote intestinal peristalsis, so it has a certain role in lipid reduction and weight loss.
The Effect of Aloe Emodin
Aloe emodin is the antibacterial effective component of rhubarb, is a kind of orange needle-like crystal (toluene) or soil yellow crystalline powder of chemical substances, can be extracted from aloe vera, has anti-tumor activity, antibacterial activity and immunosuppressive effect, purgation effect, is widely used as medicine, cosmetics raw materials.
1. Description of antitumor activity
In recent years, scholars at home and abroad have been interested in the anti-tumor effects of aloe emodin. The main anti-tumor activities are concentrated in neuroectodermal tumor, liver cancer, lung squamous cell carcinoma, skin Merkel cell carcinoma, gastric cancer, leukemia and other tumors. The anti-cancer range is wide, and aloe emodin can inhibit P388 leukemia cells and prolong the survival period. One of its mechanisms of action is to inhibit the biosynthesis of DNA, RNA and proteins in cancer cells.
2. Antibacterial activity
At the concentration of 1.5 to 25mg/ml, aloe emodin has inhibitory effects on staphylococcus, streptococcus, diphtheria bacillus, subtilis, anthrax, paratyphi bacillus and dysentery bacillus, among which staphylococcus and streptococcus are the most sensitive, and the effective concentration of inhibitory bacteria is 15-25ug/ml. Staphylococcus aureus 209P, Escherichia coli and Bacillus dysenteriae fowleri were treated at 7.5mg/L and 600mg/L in vitro, respectively. One of its mechanisms is to inhibit electron transfer in the mitochondrial respiratory chain.
Aloe emodin has a strong inhibitory effect on nucleic acid and protein synthesis of Staphylococcus aureus. Aloe emodin has a strong inhibitory effect on common clinical anaerobic bacteria, among which it can inhibit the growth of common fragile bacterium by 90% to 100%, and its MIC is slightly higher than metronidazole. At 8μg/ml, 76% to 91% of anaerobic bacteria were inhibited.
3. Immunosuppressive effect
Aloe emodin can inhibit the production of biological antibodies, inhibit the ability of carbon particle clearance, reduce the weight of immune organs, reduce the number of white blood cells, and reduce the function of abdominal macrophages. The [3H] -TDR and [3H]Urd involved lymphocytes were significantly inhibited at 100μg/ml in vitro.
4. Catharsis
Aloe emodin has strong cathartic activity, intestinal bacteria metabolize aloe emodin, rhein, rhein anthrone, the latter has a strong cathartic effect. Clinically used as a laxative, it has the effect of increasing appetite and alleviating diarrhea of large intestine. According to foreign medical reports, aloin is under the action of parasitic bacteria in the human body, hydrolyzed to aloe emodin, this aloe emodin, stimulate intestinal wall peristalsis, at the same time due to osmotic pressure changes, conducive to intestinal waste elimination, so as to achieve irritating diarrhea, this stimulating diarrhea effect on constipation and hemorrhoids have special effects. Especially for middle-aged constipation, the treatment effect is more obvious.
5. Other functions
It has the effect of making hair soft and shiny, relaxing and eliminating dandruff. In the determination of mutagenicity of hamster fibroblasts, it showed genotoxic effect. Protects teak from termites.
The Use of Aloe Emodin
It has antibacterial effect and has inhibitory effect on staphylococcus, streptococcus, diphtheria, subtilis, dysentery and other bacilli. There is also a purgative effect, clinical use as a laxative.
1. Pharmaceutical chemical intermediates.
2. Health food additives.
3. Raw materials for cosmetics and hair care.
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