Product Features:
Appearance: white powder
Content: >99%
Solubility: water soluble
Adding amount: 0.01-0.05%, added at a later stage at low temperature.
Ergothioneine is a natural antioxidant that can protect cells in the human body and is an important active substance in the body.
Ergothioneine, as a natural antioxidant, has entered people's field of vision. It has many physiological functions such as scavenging free radicals, detoxifying, maintaining DNA biosynthesis, normal cell growth and cellular immunity.
Ergothioneine can regulate intracellular redox reactions and participate in intracellular energy regulation. It is a physiological protective agent for cells, has biological and pharmacological properties, and is safe and stable.
Ergothioneine (EGT), chemically named 2-mercaptohistidine trimethyl internal salt, is the only known natural 2-thio-imidazole amino acid (2-thio-imidazole). The human epidermis is composed of corneocytes, melanocytes and fibroblasts. All three types of cells can express the EGT transporter ETT and therefore can absorb and accumulate EGT. EGT has an absorption wavelength similar to that of DNA in the ultraviolet absorption range, which can effectively protect against damage caused by ultraviolet radiation. At the same time, EGT has extremely strong antioxidant ability and can reduce 70% The cells remain reducing and can also inhibit the formation of various reactive oxidants, lipid peroxidation and apoptosis of irradiated cells. In addition, EGT has good chemical stability, can accumulate in epidermal cells, and is non-toxic. Therefore, EGT has broad application prospects in the cosmetics industry. It has the functions of preventing radiation, whitening, reducing wrinkles, removing acne and eye bags, shrinking pores, delaying aging, preventing hair loss, promoting hair regeneration and improving hair quality.
Source:
1. Biological extraction method:
Ergothioneine is extracted from edible fungi or animal tissues, but the content of ergothioneine in the raw materials is still very low. There are problems such as many impurities in the raw materials, drug residues, customs and taboos, and high extraction costs.
2. Biosynthetic preparation
Using edible fungus strains as raw materials, deep fermentation technology is used to obtain high-purity ergothioneine through membrane separation and other methods. The purity can reach more than 98.5%, and the extraction efficiency is improved; water extraction is used, which is safe and environmentally friendly from beginning to end, relying on Large-scale production can reduce costs.
3. Chemical synthesis method:
The synthesis process is difficult. Once the levorotation process problem is overcome, the yield and purity can be greatly improved, and the cost can be reduced at the same time.
Mechanism of action:
1. Ergothioneine has a strong ability to scavenge OH-, but it does not react quickly with O2-. Other antioxidants are unstable in aqueous solutions and are easily oxidized, but ergothioneine is more stable, which is one of its greatest features.
2. The antioxidant effect of ergothioneine is also reflected in chelating divalent Fe 2+ and Cu2+ to prevent the formation of H2O2 and OH. Ergothioneine prevents oxidation, while other antioxidants mainly remove oxidation residues. product.
3. Ergothioneine can stimulate the natural antioxidant defense system of cells and upregulate proteins involved in antioxidant cellular pathways, including Nrf2, heat shock protein (Hsp70), superoxide dismutase (SOD), and glutathione reductase. and catalase, and down-regulates the pro-oxidative enzyme NADPH.
4. Ergothioneine can absorb ultraviolet light and has a cell protective effect, which can reduce ultraviolet-induced damage and cell death. In keratinocytes exposed to UV radiation, the results showed a significant decrease in caspase-9 activity while increasing cell survival.
5. Ergothioneine inhibits H2O2-induced apoptosis by inhibiting p38-MAP, repairs damaged cells, and reduces inflammatory response.
Effect on skin:
1. Whitening
Ergothioneine is a natural antioxidant that is highly protective for cells, non-toxic, and not easily oxidized in water, allowing them to reach concentrations in certain tissues and stimulating the cells' natural antioxidant defense system. Research results show that adding 0.01% to 0.03% ergothioneine in cosmetics can hinder the formation and deposition of melanin and whiten the skin.
2. Protect from light damage
Within the ultraviolet absorption range, ergothioneine has an absorption wavelength similar to that of DNA, which can minimize the formation of reactive oxygen species and protect cells from radiation damage. Therefore, ergothioneine can be used as a physiological filter for ultraviolet light.
3. Anti-photoaging
ROS-mediated photodamage caused by ultraviolet (UV) radiation leads to skin roughness, wrinkling, pigmentation, and aging, and ergothioneine protects cells and skin from aging by activating the skin's antioxidant system. Ergothioneine and its derivatives can reduce or even prevent protein glycation.
4. Anti-inflammation and acne removal
Inflammation is the body's response when the skin is infected. Excessive ultraviolet radiation and excessive pressure are all causes of skin inflammation. Research shows that ergothioneine can play an anti-inflammatory role in skin cells, and when combined with vitamin C, it will have more significant effects.
5. Synergy
Ergothioneine can regulate intracellular redox reactions, participate in intracellular energy regulation, and is a physiological protective agent for cells. It has biological and pharmacological properties and is safe and stable. Therefore, adding ergothioneine to a product can not only maintain the stability of other ingredients, but also promote the absorption of active ingredients by cells, which has a good synergistic effect and effectively enhances the efficacy of other ingredients, achieving 1+1 >2 effect. For example, using ergothioneine in an antioxidant product not only exerts a powerful antioxidant effect on its own, but can also synergize with other antioxidants to enhance its vitality.
Application:
1. Antioxidant
2. Anti-wrinkle: Improve aging and wrinkles caused by UV
3. Cell protection
4. Sunscreen: protects against DNA damage caused by UVA
5. Anti-aging
6. Whitening
7. Anti-inflammatory
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