Latin name: Coffea L. (Coffea robusta or Coffea arabica) Extraction part: dried seeds
Active ingredient: total chlorogenic acid
Product specifications: Chlorogenic acid 10%, 20%, 25%, 30%, 35%, 45%, 50% Total Chlorogenic acid 10%-70%
Product appearance: Light brown powder
CAS number: 327-97 -9
Molecular formula: C16H18O9
Molecular weight: 354.31
Plant source: The seeds of the Rubiaceae plants Coffea arabica L., Coffea canephora Pierre ex Froehn. and Coffealiberica Bul1.ex H1en.
Solubility: good water solubility, easily soluble in hot water, solubility in water is about 4% at 25°C, easily soluble in polar solvents such as ethanol, acetone, methanol, slightly soluble in ethyl acetate, and difficult to dissolve in chloroform , ether, benzene and other lipophilic organic solvents.
Plant origin: Yunnan, Guangxi, Guangdong, Hainan Province
Efficacy: Green coffee bean extract comes from the seeds of Coffea arabica, Coffea mesocarpa and Coffea macrocarpa of Rubiaceae plants. Its main component is chlorogenic acid, which has antihypertensive,kidney-tonifying, antioxidant and other effects. It can also be used in health food to make the health food sweet and delicious.
Introduction
Green coffee bean extract is extracted from the seeds of small fruit coffee, medium fruit coffee and large fruit coffee of rubiaceae, chlorogenic acid is the main active substance, and contains alkaloid compounds such as caffeine and trigonelline. Chlorogenic acid is a kind of phenylpropanoid compound produced by shikimic acid pathway in the aerobic respiration process of plants. It has the functions of antibacterial, antiviral, increasing white blood cell, protecting liver and gallbladder, anti-tumor, lowering blood pressure, lowering blood lipids, clearing free radicals and stimulating central nervous system. The right amount of caffeine will stimulate the layer of the brain skin, promote sensory judgment, memory, emotional activities, so that the myocardial function becomes more active, blood vessels dilate blood circulation, and improve metabolic function, caffeine can also reduce muscle fatigue, promote the secretion of digestive fluid. But large doses or long-term use can also cause damage to the human body, can cause paroxysmal convulsions, damage the liver, stomach, kidney and other important internal organs. Green coffee bean extract is widely used, mainly in pharmaceutical, daily chemical and food industries.
Source:
The basic source is the seed of small fruit coffee, medium fruit coffee and large fruit coffee of Rubiaceae. Evergreen shrubs or small trees. Leaves opposite, leathery, long ovate. Peanut in axillary, white. The berry is oval in shape and contains two seeds. Native to tropical eastern Africa. Brazil is the world's largest producer and exporter of coffee. China has introduced small-fruit coffee, medium-fruit coffee and large-fruit coffee from Ethiopia and other places, and cultivated in Hainan, Yunnan and Taiwan. Small fruit coffee is suitable for cultivation in the altitude of 600 ~ 1200 meters, relatively low temperature tolerance, but weak disease resistance; It is suitable for cultivation at an altitude of 300 to 700 meters. It is not drought tolerant or wind resistant, but it has high yield and good quality. The fruit is not easy to fall off after ripening. Big fruit coffee is suitable for cultivation in lowlands below 300 meters above sea level, which is both drought-resistant and resistant to pests and diseases, and has a strong taste.
The main ingredients
The main ingredients are rich in minerals, proteins, fats, carbohydrates, vitamins, phenolic acids (chlorogenic acid), trigonelline and other alkaloids, caffeine and so on. Chlorogenic acid: Molecular formula C16H18O9. Molecular weight 354.30. The acicular crystal is obtained from water, which is semi-hydrate and becomes non-hydrate at 110℃. 1.65 g/cm3 density, melting point 205-209 ℃, boiling point 665 ℃, flash point 245.5 ℃, the refractive index to 37 °, [alpha] D25-33. 5 ° (water, C = 1), K = 2.2 x 10-3 (27 ℃). It has a weak sour taste and is astringent. At 25℃, the solubility in water is 4%, it is easily soluble in hot water, soluble in ethanol, acetone, slightly soluble in ethyl acetate, insoluble in chloroform, ether and carbon disulfide. Azeotrope with concentrated hydrochloric acid to produce blue dye. It can make bromine water fade, and azeotrope with concentrated hydrogen iodide to benzoic acid, and water at 230℃ co-thermal decomposition into phenol, and dilute hydrochloric acid co-thermal decomposition into caffeic acid and cinchonic acid, etc., room temperature and dilute alkali interaction only caffeic acid and cinchonic acid.
Pharmacological effects:
1. Antioxidant and free radical scavenging effects in the body. Green coffee bean extract has strong total antioxidant capacity within a certain concentration range, strong DPPH free radical scavenging activity, and strong iron ion reducing ability. But it does not have the ability to chelate metal ions. Green coffee bean extract has strong antioxidant activity and is a potential natural antioxidant.
2. Antibacterial and antiviral effects Chlorogenic acid has the effects of antiviral, hemostatic, increasing white blood cells, and shortening blood coagulation and bleeding time. Chlorogenic acid has significant inhibitory and killing effects on a variety of pathogenic bacteria, such as Staphylococcus aureus, hemolytic Streptococcus, Shigella dysenteriae, Typhimurium, and Pneumococcus. Chlorogenic acid has obvious effects on acute throat inflammation and skin diseases, and is clinically used to treat acute bacterial infections. 3. Anti-mutation and anti-tumor effects Chlorogenic acid has a strong ability to inhibit mutations, can inhibit mutations caused by aflatoxin B and mutations caused by subdigestive reactions, and can effectively reduce bone marrow red blood cell mutations caused by γ rays; Chlorogenic acid can achieve cancer prevention and anti-cancer effects by reducing the utilization rate of carcinogens and their transportation in the liver. Chlorogenic acid has a significant inhibitory effect on colorectal cancer, liver cancer and laryngeal cancer, and is considered an effective chemoprotective agent against cancer. 4. Cardiovascular protective effect. Chlorogenic acid, as a free radical scavenger and antioxidant, has been proven by a large number of experiments. This biological activity of chlorogenic acid can have a protective effect on the cardiovascular system. Chlorogenic acid can protect vascular endothelial cells by scavenging free radicals and resisting lipid peroxidation, thereby playing a role in preventing and treating atherosclerosis, thromboembolic diseases, and hypertension. 5. Other effects: Chlorogenic acid and its derivatives have shown certain inhibitory effects in anti-HIV research. Chlorogenic acid has special inhibitory effects on HAase and glucosamine monophosphatase, which is beneficial to wound healing and skin moisturizing. It has certain effects on joint lubrication and inflammation prevention. Oral administration of chlorogenic acid can significantly stimulate the secretion of bile and has a choleretic effect; chlorogenic acid also has a significant inhibitory effect on gastric ulcers, and it can also effectively inhibit the hemolysis of red blood cells caused by H202 in rats.
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