Physicochemical Properties of Vitamin A Palmitate: Light yellow liquid. It is a kind of vitamin A (VitaminA). It is a Chemicalbook ester of retinol combined with palmitic acid. Palmitic acid is a saturated fatty acid and the main component of palm oil. Retinyl palmitate is easily absorbed by the skin and then converted into retinol. It is a yellow or yellow-red solid or oily substance. Sensitive to air, heat, light and humidity. Insoluble in water, soluble in ethanol, easily soluble in ether, chloroform, acetone and grease. Melting point 28~29℃.
Product use: Vitamin medicine, cosmetics
CAS number: 79-81-2
Molecular formula: C36H60O2
Adding amount:
The safe dosage of vitamin A palmitate needs to be judged according to the specific situation and cannot be generalized. In general, the safe daily dose of vitamin A palmitate for adults is 500-1000 micrograms
Purpose: It can be absorbed through the skin, resist keratinization, stimulate the growth of collagen and elastin, and increase the thickness of the epidermis and dermis. Enhance skin elasticity, effectively eliminate wrinkles, promote skin renewal, and maintain skin vitality. Used in eye cream, moisturizing cream, repair cream, shampoo, conditioner, etc.
Synthesis method and process of vitamin A palmitate:
1) Dissolve vitamin A alcohol (Compound (II)) and halogenated amide (Compound (III)) in an organic solvent, then add a phosphorus compound (Compound (IV)) to perform a halogen replacement reaction, and filter to remove by-products produced during the reaction. , the filtrate is cooled to crystallization, and vitamin A halide (compound (V)) is obtained;
2) Dissolve vitamin A halide (compound (V)) and palmitate (compound (VI)) in an organic solvent, then add an organic base (compound (VII)) to react, add water to wash the organic layer, and evaporate under reduced pressure. organic solvent to obtain vitamin A palmitate.
In step 1), the mass ratio of vitamin A alcohol, haloamide, organic solvent and phosphorus compound can be: vitamin A alcohol: haloamide: organic solvent: phosphorus compound = 1: (0.5~1): ( 2～10): (0.5～1.5), preferably: vitamin A alcohol: haloamide: organic solvent: phosphorus compound = 1: (0.5～0.8): (2～7): (0.5～1.3), the most Preferably: vitamin A alcohol: halogenated amide: organic solvent: phosphorus compound = 1: (0.5~0.7): (3~5): (0.7~1.2); the organic solvent can be selected from alkanes, aromatic hydrocarbons, and haloalkanes, One of ethers, etc., the alkanes can be selected from alkanes with 1 to 12 carbon atoms; the aromatic hydrocarbons can be selected from aromatic hydrocarbons with 0 to 2 substituents; the haloalkanes can be selected from 1 to 2 carbon atoms. Halogenated alkyl with 2 to 4 carbon atoms and 1 to 4 halogens; the ethers can be selected from ethers with 2 to 4 carbon atoms; the organic solvent is preferably selected from benzene, toluene, n-hexane, cyclohexane, heptane Alkane, tetrahydrofuran, dichloromethane, chloroform, etc., preferably benzene and n-hexane, etc.; the phosphorus compound can be selected from triphenylphosphine or triphenoxyphosphine, etc.; the temperature of the halogen replacement reaction can be 0 to 50°C, preferably 0 to 30°C, the halogen replacement reaction time can be 1 to 10 hours, preferably 1 to 5 hours; the cooling temperature can be -20°C.
In step 2), the mass ratio of the vitamin A halide, palmitate, organic solvent and organic base can be: vitamin A halide:palmitate:organic solvent:organic base=1:(0.9~1.2) : (3～10): (0.2～1), preferably: vitamin A halide: palmitate: organic solvent: organic base = 1: (0.9～1.1): (3～7): (0.3～0.7 ), preferably: vitamin A halide: palmitate: organic solvent: organic base = 1: (0.9~1.1): (3~5): (0.3~0.6); the organic solvent can be selected from alkanes, One of aromatic hydrocarbons, alkyl halides, ethers, etc., the alkane can be selected from alkanes with 1 to 12 carbon atoms; the aromatic hydrocarbon can be selected from aromatic hydrocarbons with 0 to 2 substituents; the alkyl halide can be selected from Halogenated alkyl with 1 to 2 carbon atoms and 1 to 4 halogens; the ethers can be selected from ethers with 2 to 4 carbon atoms; the organic solvent is preferably selected from benzene, toluene, n-hexane, cyclohexane, One of hexane, heptane, tetrahydrofuran, dichloromethane, chloroform, etc., preferably benzene and n-hexane, etc.; the organic base can be selected from one of alkylamines, pyridines, quinolines, etc., The alkyl amines can be selected from organic amine compounds with 1 to 3 substituents on the N atom, or the substituents are alkyl groups with 1 to 4 carbon atoms; the pyridines can be selected from pyridine rings. It has 1 to 3 substituents, and the substituent is hydroxyl or an alkyl group with 1 to 4 carbon atoms; the quinoline can be selected from the group consisting of quinoline rings with 1 to 3 substituents, and the substituent is hydroxyl or alkyl with 1 to 4 carbon atoms. Alkyl group with 1 to 4 carbon atoms; the organic base is preferably selected from diethylamine, triethylamine, pyridine, α-methylpyridine, 1,2-dimethylpyridine, 4-hydroxy-2-methyl One of pyridine, γ-trimethylpyridine, quinoline, dimethylquinoline, etc., preferably one of triethylamine, pyridine, α-methylpyridine, γ-trimethylpyridine, etc.; The temperature of the reaction can be 0-50°C, preferably 10-30°C, and the reaction time can be 1-10 hours, preferably 2-4 hours.
Purpose: This vitamin is fat-soluble and is an essential factor in regulating the growth and health of epithelial tissue cells. It can thin the surface of rough and aging skin, promote normalization of cell metabolism, and have obvious anti-wrinkle effects. It can be used in high-end cosmetics such as skin care, wrinkle removal, and whitening. Recommended usage: It is recommended to add it to the oil phase. An appropriate amount of antioxidant-BHT should be added. The temperature should be around 60°C, and it can be dissolved.
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