Fucoxanthin is a natural pigment of the xanthophyll class of carotenoids and accounts for more than 10% of the total of approximately 700 naturally occurring carotenoids. Widely present in various algae, marine phytoplankton, aquatic shellfish and other animals and plants. It has pharmacological effects such as anti-inflammatory, anti-oxidation, weight loss, nerve cell protection, and increasing the content of ARA (arachidonic acid) and DHA (docosahexaenoic acid) in mice. It is used as medicine, skin care and beauty products and health care products. widely used in the product market.
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According to the WHO research report, the global obesity trend is becoming more and more serious, and the main reasons are closely related to the diet, physical activity and physical exercise reduction. Especially with the increase of high-carbohydrate, high-fat, and high-energy diets, the intake of vitamins and minerals is reduced, which leads to the imbalance of human nutrition intake, which is a very important reason. In order to prevent diseases caused by such unhealthy lifestyles, as well as concerns about the side effects of medicines, functional ingredients in food have come into focus. Fucoxanthin is an important food ingredient that can prevent and improve obesity.
Fucoxanthin, also known as fucoxanthin and fucoxanthin, is one of the important types of special carotenoids in seaweed. It contains a special structure of propadiene and alkylene oxide. This special structure determines its anti-obesity effect. physiological activity.
1. Reduce fat accumulation
Fucoxanthin can not only improve insulin resistance, but also reduce blood sugar level and fat accumulation by regulating the secretion of cytokines in white adipose tissue. Adipocytes play a key role in the homeostasis of energy in the body, while adipose tissue stores energy in the form of lipids and determines the release of fatty acids in response to energy deficiency and nutritional signals.
2. Reduce energy intake
In the mouse experiment, mice were perfused with a certain amount of fucoxanthin and fucoxanthol, and a control group was set up. After four hours, it was found that fucoxanthin and fucoxanthol reduced the release of triglycerides into the lymph by 50%. liquid. However, the increase of triglycerides in lymph and blood in mice added with carotenoids was far less than that in the control group, indicating that fucoxanthin or fucoxanthin can inhibit the absorption of lymphatic triglycerides and the absorption of triglycerides. Elevated concentrations of esters in systemic blood. Although other studies have shown that compared with some anti-obesity drugs used in clinical treatment, fucoxanthin has a much lower inhibitory effect on obesity, and the effect is slightly worse, but it has higher safety and fewer side effects. Diarrhea is less likely. Therefore, compared with drug therapy, fucoxanthin may be a milder and safer choice for preventing postprandial hyperlipidemia.
3. Inhibit lipogenesis
The main feature of obesity is the excessive deposition of fat, which is related to the functional changes and structural morphology of fat cells. Studies have shown that fucoxanthin can significantly reduce body weight, as well as fat wet weight and liver weight, improve fatty liver degeneration caused by high fat, and reduce the content of free fatty acids in serum. In addition, fucoxanthin can also increase antibiotic The role of other body gene expression. Experiments in mice have proved that fucoxanthin can reduce obesity through the expression of uncoupling proteins in white adipose tissue. Fucoxanthin and its metabolite fucoxanthol can inhibit the differentiation of mature adipocytes. This shows that fucoxanthin can not only activate the expression of uncoupling protein (UCP1) in white adipose tissue but also inhibit the maturation of adipocytes.
4. Improve Leptin Resistance
Leptin is a protein product expressed by obesity genes and secreted by adipose tissue, which can bind to its receptors to realize its function. Leptin deficiency or receptor defects may lead to obesity. Leptin mainly reduces body weight, suppresses appetite, increases energy consumption and reduces energy intake by regulating the central nervous system. At the same time, it can also regulate the balance of glucose metabolism, inhibit fat synthesis and promote fat decomposition. The current study found that fucoxanthin can significantly reduce the expression of leptin mRNA in mice, and at the same time reduce the level of leptin in plasma, which shows from the side that fucoxanthin can achieve anti-obesity through its improvement of leptin Effect.
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