Spermidine

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of spermidine in China. With abundant experience, we warmly welcome you to wholesale bulk spermidine for sale here from our factory. Quality products and reasonable price are available.

Spermidine is a low molecular weight aliphatic carbide containing 3 amine groups and is one of the natural polyamines present in organisms. It is biosynthesized from putrescine (butanediamine) and adenosylmethionine. It can inhibit neuronal synthases, bind and precipitate DNA, purify DNA-binding proteins, and stimulate T4 polynucleotide kinase activity. Studies show it can prevent the onset of Alzheimer's disease.

It is a polyamine metabolite widely present in living organisms. It was first found in semen, which is also the origin of its name. Of course, spermidine is not only found in semen, it is also found in other tissues of the body, such as the ovaries. In recent years, more and more studies have shown that spermidine has miraculous and powerful anti-aging effects and may improve age-related decline in ovarian function and impaired fertility. However, the effects of spermidine on the reproductive system of aged female animals and its specific mechanisms have not been studied in detail.

The physiological activity of spermidine is manifested in many aspects. First, it is a polyamine that participates in a variety of biochemical processes within cells. In particular, spermidine plays a key role in the autophagy process. Autophagy is a process by which cells digest themselves to recycle and reuse intracellular components. Disturbance of this process has been implicated in many diseases, including neurodegenerative and metabolic diseases. In 2016, the research on autophagy won the Nobel Prize in Physiology and Medicine, which made the importance of spermidine more prominent because it can activate this process and plays a vital role in maintaining cell homeostasis.

It supports sample testing and third-party testing. It has its own factory and many years of production experience. It has advanced equipment and can guarantee product quality and delivery. You can visit the factory. There are good after-sales service and very preferential prices, and there will be different discounts according to different order quantities.

Product Information Table

1. Spermidine can regulate physiological and pathological processes such as cell proliferation, cell senescence, organ development, and immunity. Recent studies have shown that spermidine plays an important role in regulating processes such as synaptic plasticity, oxidative stress, and autophagy in the nervous system.

2. Spermidine maintains cell membrane stability, increases antioxidant enzyme activity, and improves photosystem II (PSII) and related gene expression. Spermidine also significantly reduced H2O2 and O2.- contents.

3. Inhibit neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; also used to purify DNA-binding proteins. Stimulates T4 polynucleotide kinase activity.

4. Delay aging. Spermidine has a very good anti-aging effect. Spermidine can promote cell autophagy, promote the recovery of cell components, effectively help the body remove dead cells and toxic cells, and delay the aging of the body. Moreover, spermidine It also has good antioxidant properties, can remove free radicals in the body, avoid cell damage, and delay aging. It is especially suitable for people who want to stay young forever.

5. Prevent Alzheimer's disease. Spermidine will participate in various cell processes in the body, such as gene transcription, translation, cell proliferation and cell survival that we are familiar with. It also has a good effect on the stability of genomic DNA. Supplementing spermidine It can effectively promote cell activity and effectively prevent the occurrence of Alzheimer's disease. It is very suitable for middle-aged and elderly people.

6. Protect nerves Spermidine has a very good protective effect on neuron damage caused by inflammation, oxidative stress and ischemia. Spermidine can effectively protect nerves, protect neuron damage, prevent the deterioration of damaged nerves, and accelerate the recovery of damaged nerves. It can inhibit the growth of damaged nerves, repair damaged nerves, protect nerves and promote good health.

7. In addition to participating in autophagy, spermidine also affects the behavior of stem cells. Stem cells are a type of cells with self-replication ability and multi-directional differentiation potential, which are of great significance for tissue regeneration and repair. Studies have found that spermidine can promote the proliferation and differentiation of stem cells, further affecting tissue regeneration and repair.

8. In terms of blood pressure regulation, spermidine also shows certain effects. Some studies have shown that spermidine can alter blood pressure by affecting the contraction and relaxation of vascular smooth muscle cells. This discovery provides new possibilities for the treatment of cardiovascular diseases such as hypertension.

9. Activate metabolism

Additionally, spermidine activates a master metabolic switch, an enzyme called AMP-activated protein kinase (AMPk). AMPk activity plays an important role in energy metabolism and is also related to life expectancy. As we age, cellular AMPk activity decreases, leading to insulin resistance, liver damage, abdominal (visceral) fat accumulation, and loss of muscle mass (sarcopenia). Activation of AMPk may be a key antiaging effect of spermidine.

It is an important raw material for pharmaceutical synthesis and is widely used in the synthesis of pharmaceutical intermediates.

Can prevent the onset of Alzheimer's disease.

Related research on spermidine delaying aging

Through metabolomic studies, it was found that spermidine levels in the ovaries of old mice (approximately 54 weeks old, the end point of female mice's reproduction) were significantly lower than those of young mice (7 weeks old, the starting point of sexual maturity of female mice). , this decline is also accompanied by reduced oocyte quality and other signs of ovarian aging. Therefore, a hypothesis was raised - is insufficient spermidine content one of the important reasons for the decline in oocyte quality in aged mice? Can spermidine supplementation improve oocyte quality and fecundity in aged mice?

Metabolomic analysis of the ovaries of aged mice shows decreased spermidine levels in the ovaries

In order to explore the causal relationship between spermidine levels and fertility in female mice, the research team supplemented spermidine in aged mice through intraperitoneal injection. They found that aged mice supplemented with spermidine showed improvements in follicle quantity and quality, specifically preantral and antral follicles, which are the main diagnostic predictors of ovarian reserve in humans. In fact, even just supplementing spermidine through drinking water can still reverse signs of aging in oocytes.

Increasing spermidine levels promotes follicle development and oocyte maturation in female aged mice, and also improves in vitro fertilization capacity and early embryonic development potential. Even more strikingly, supplementing old female mice with spermidine nearly doubled their litter size.

Effects of spermidine supplementation on fertilization ability and embryonic development potential of oocytes in aged mice

In addition, the research team also observed similar effects of spermidine in laboratory-cultured old pig oocytes, suggesting that spermidine's mechanism of action may be consistent across species. Although spermidine was already known to have anti-aging properties, we were still surprised by its dramatic effects on oocytes.

The specific molecular mechanisms underlying this phenomenon were further explored. They observed a decrease in autophagy, specifically mitophagy, in aged oocytes, and spermidine supplementation seemed to reestablish mitophagy in aged oocytes and also improve mitochondrial quality, as observed by Inferred from the increase in mitochondrial membrane potential. In addition, pharmacological inhibition of mitophagy can effectively prevent the beneficial effects of spermidine supplementation, further supporting the above view.

Effects of spermidine supplementation on mitochondrial phagocytic activity of oocytes in aged mice

The experimental team clarified that NMN, the precursor metabolite of NAD+, restores NAD+ levels in old animal oocytes and improves mitochondrial function, thereby enhancing the egg meiotic maturation rate, fertilization ability and embryonic development potential after fertilization, and ultimately improves animal litter The mechanism of numbers.

Professor Xiong Bo said that both NMN and spermidine restore the fertility of aged animals by targeting mitochondria, but the specific mechanisms of action are different. It is still unclear whether the two substances have additive effects, which is also a subject for further research in the future. direction.

Spermidine is essential for maintaining normal fertility in aged female mice. Supplementing spermidine levels can restore mitophagy in aging oocytes and improve age-related decline in ovarian function and impaired fertility.

This research result opens up a new way to extend women's reproductive lifespan and provides a solution to humanity's pressing fertility problems.

Research model: Declining spermidine levels a key factor in age-related loss of fertility

In mouse studies, it was found that the concentration of spermidine is very important. Too much spermidine will damage egg quality, and too little will not work. Therefore, before using spermidine to extend human reproductive lifespan, it is necessary to explore the optimal dose and duration of supplementation to further determine safety and effectiveness. The team's next step will be to test spermidine's potential to enhance fertility in human oocytes in the laboratory.

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