Aloe Emodin Powder

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of aloe emodin powder in China. With abundant experience, we warmly welcome you to wholesale bulk aloe emodin powder for sale here from our factory. Quality products and reasonable price are available.

• High-Purity Standardized Raw Material Supply: The company's main product is 95% pure aloe-emodin powder. Utilizing differentiated extraction processes, the product is separated and purified using two mature preparation technologies: ethanol extraction and toluene extraction. This produces two grades of powder: dark brown and orange-yellow. The content of the active ingredients in the raw materials is stable.
• Self-Developed and Self-Produced, Rigorous Quality Control System: All aloe-emodin raw materials come from the company's own production plant, enabling independent control of the entire production process. From raw material input and extraction to finished product packaging, the entire process is standardized. Before leaving the factory, finished products undergo multi-dimensional precision testing, strictly controlling impurity content, purity indicators, and physicochemical stability to ensure uniform quality between batches.
• Complete Qualifications and Strong Cross-Border Compliance: All products are equipped with complete testing reports and a full set of certifications. Production standards conform to industry-standard quality, facilitating smooth qualification reviews and document submissions for overseas markets.
• Direct Supply from the Source Factory, Outstanding Cost Advantage: By directly supplying from the manufacturer, the company offers high-quality, cost-effective orders while ensuring stable raw material quality. It is also equipped with a professional service team that can provide technical consultation, selection guidance and full-cycle after-sales support, creating an efficient and long-term cooperation system.

Aloe-emodin is a functional active ingredient naturally extracted from aloe vera. It belongs to the hydroxyanthraquinone class of tricyclic natural organic compounds and is mainly distributed in the leaves, roots, and rhizome tissues of aloe vera. This substance possesses antibacterial properties and exhibits specific inhibitory effects on neuroectodermal tumors both in vivo and in vitro.

Anthraquinone compounds generally possess antitumor pharmacological activity, and their derivatives have rich structures and broad biological effects. Utilizing autophagy regulation mechanisms, these substances can effectively improve the problem of drug resistance in tumor treatment. Aloe-emodin is a high-potential derivative in this field.

This component exists in various forms within plants. In aloe vera, it is mostly in a free state, while in medicinal materials such as senna leaves, it often exists stably in a glycoside-bound state. In terms of physicochemical properties, after crystallization from ethanol and toluene, it appears as orange-yellow needle-like crystals with a relative molecular mass of 270.25 and a melting point of 223–224℃. It can sublimate in a carbon dioxide atmosphere.

In addition, aloe-emodin can inhibit cholesterol absorption and enhance intestinal peristalsis and metabolism, thus playing a comprehensive role in regulating blood lipids and assisting in weight management.

Antibacterial Effects

Aloe-emodin exhibits significant inhibitory effects against various pathogenic bacteria, including Staphylococcus aureus, Streptococcus, Bacillus anthracis, and Shigella dysenteriae. It can block electron transport in the mitochondrial respiratory chain, strongly inhibiting the synthesis of nucleic acids and proteins in pathogenic bacteria, and also shows significant antibacterial activity against common clinical anaerobic bacteria.

Laxative Effects

This component can promote appetite and enhance intestinal peristalsis. In the body, aloin is hydrolyzed into aloe-emodin by intestinal flora, which accelerates the excretion of metabolic waste by stimulating the intestinal wall and regulating intestinal osmotic pressure. Its mild excretory-promoting effect can effectively improve constipation and hemorrhoid discomfort, with particularly outstanding effects on constipation in middle-aged and elderly individuals.

Inhibition of Overactive Immune System

Immune disorders can easily induce autoimmune diseases and damage normal tissues. Aloe-emodin can regulate antibody production, soothe overactive immune responses, and thus exert a soothing and anti-allergic physiological effect.

Lipid-lowering and weight-loss effects

It can block the absorption of cholesterol in the human body, and combined with its highly efficient intestinal metabolism-promoting properties, it bidirectionally regulates lipid metabolism, achieving a comprehensive effect of assisting in lipid-lowering and weight control.

Immunosuppressive effects
It can inhibit antibody production, weaken the physiological activity of macrophages, and regulate white blood cell levels and the physiological state of immune organs. In vitro experiments have confirmed that at appropriate concentrations, it can significantly inhibit lymphocyte metabolic activity, demonstrating clear immunomodulatory value.

Laxative effects
Aloe vera extract is metabolized by intestinal microorganisms to produce active substances such as rhein and anthrone, possessing strong laxative activity. It achieves bowel movement by stimulating intestinal peristalsis and changing intestinal osmotic pressure. Clinically, it can be used to treat constipation and is suitable for various types of chronic defecation difficulties.

1. Intermediate of pharmaceutical and chemical industry.

2. Health food additives.

3. Raw materials for cosmetics and hair care.

Aloe-emodin derivatives exert anti-atherosclerotic effects by promoting AMBRA1-mediated endothelial cell autophagy), published in the European Journal of Pharmacology. This study reveals the protective effect of aloe-emodin derivatives on atherosclerosis and mechanism.

Atherosclerosis is an inflammatory disease related to endothelial dysfunction. It has a high mortality rate worldwide, which not only seriously harms people's health, but also places a huge burden on the medical and health system. However, there are currently no drugs that are safe and effective enough to treat and prevent atherosclerosis.

Aloe-emodin is an anthraquinone compound extracted from the plant Aloe vera. It has a variety of pharmacological activities, including lipid-lowering, anti-diabetic and cardiovascular disease prevention. However, aloe-emodin has poor intestinal absorption, short elimination half-life, and low in vivo bioavailability, which limit its clinical application.

To address these problems, we modified aloe-emodin and replaced the hydroxyl group on the anthracene ring with a succinyl ethyl ester group to obtain a new aloe-emodin derivative. Compared with aloe-emodin, aloe-emodin derivatives have enhanced fat solubility, reduced toxicity, and improved bioavailability.

In this study, we found that aloe-emodin derivatives can reduce endothelial cell damage, inhibit lipid deposition, inflammatory damage and plaque fibrosis, and inhibit the occurrence and development of atherosclerosis. And at the same dose, aloe-emodin derivatives are more effective than aloe-emodin. In terms of mechanism, we found that aloe-emodin derivatives can upregulate the expression of Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1) in endothelial cells, promote endothelial cell autophagy, and thereby improve arterial Atherosclerosis.

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