What is dihydromyricetin?
Dihydromyricetin powder is an extract of grapevine tea. The content of grapevine tea is the most abundant, as high as 37.4%~38.5%. , is the main active component of flavonoids in rattan tea, and has multiple effects such as free radical scavenging, antioxidant, and anti-inflammatory. Dihydromyricetin is a special flavonoid compound. It has special effects on alcoholic liver disease, fatty liver disease, lowering blood lipids and blood sugar, increasing SOD activity, and protecting the liver.
Dihydromyricetin is a polyphenolic hydroxydihydroflavonol compound that is found in plants of the Vitaceae, Myricaceae, Garcinaceae, Euphorbiaceae, Olivaceae, Leguminosae and other plants, among which plants of the genus Vitaceae The toothed snake grape, that is, the most abundant content in vine tea, is as high as 37.4% to 38.5%.
In addition to the general properties of flavonoids such as hepatoprotective, antioxidant, and antibacterial, dihydromyricetin also has an improving effect on hypertension, hyperlipidemia, and abnormal blood sugar. In particular, recent studies have found that it has an effect on Alzheimer's disease. , Parkinson's disease, alcohol addiction and depression also have good neuroprotective activity.
Dihydromyricetin is mostly extracted from the dried leaves of vine tea - Ampelopsis grossedentata.
Among them, the main active ingredient is flavonoids, and dihydromyricetin is a relatively special kind of flavonoids. In addition to the general properties of flavonoids, it can also relieve alcohol poisoning, prevent alcoholic liver disease, fatty liver, and inhibit liver cells. worsening morbidity and other effects.
Product Details Table
| Product Name | Dihydromyricetin | Other Name | DMY |
| CAS NO | 27200-12-0 | MW | 320.25 |
| MF | C15H12O8 | Specification | 98% |
| Storage | Store in a cool, dry place, away from light and high temperature | ||
| Shelf Life | 24 Month | ||
Source
What are the benefits?
Reduce the impact of alcohol on the brain
Most of the common symptoms of alcoholism, such as reduced inhibitions, slurred speech and loss of balance, are caused by the action of GABA receptors in the brain. Even if blood alcohol levels remain high, dihydromyricetin has the ability to counteract this effect.
Improve liver function
The liver needs enough time to completely process the alcohol and eliminate it from the system. With the help of DHM, the liver can work faster and the patient can wake up faster.
Antibacterial effect
Dihydromyricetin can inhibit and kill a variety of bacteria and fungi, such as Escherichia coli, Salmonella paratyphi B, Pseudomonas aeruginosa, Bacillus subtilis, Candida albicans, Staphylococcus aureus, Aspergillus flavus, Niger Aspergillus and other inhibitory and killing effects.
Anti-oxidize effect
The enzyme system that scavenges free radicals in the body mainly includes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). Malondialdehyde (MDA) is the oxidation product of lipid peroxidation reaction caused by free radicals in the body and is cytotoxic. Dihydromyricetin can reduce the production of MDA and increase the activity of SOD and GSH-Px, thereby playing an antioxidant role.
Anti-fatigue
Dihydromyricetin can effectively reduce mitochondrial damage induced by hypobaric hypoxia, and can reduce the activities of blood urea, serum lactate dehydrogenase and creatine kinase. It exerts anti-fatigue effects by promoting mitochondrial biogenesis in skeletal muscle and regulating dynamic changes in mitochondrial fission and fusion.
Anti-inflammatory, analgesic and antibacterial
Modern research has found that dihydromyricetin in rattan tea has a significant inhibitory effect on various tested bacteria, including cocci, bacilli, gram-positive bacteria and gram-negative bacteria, and also has a certain inhibitory effect on yeasts and molds. As the concentration of dihydromyricetin increases, the antibacterial power will also increase, which shows that the main antibacterial component of rattan tea is dihydromyricetin.
neuroprotection
Dihydromyricetin can not only directly participate in the synaptic electrical signal transmission process in the brain as an inhibitory neurotransmitter receptor function regulating molecule, but can also regulate neural function by upregulating the expression of neurotrophic factors, and affect cell apoptosis and autophagy. It indirectly repairs damaged or aging neural functions, improves a variety of neuropsychiatric diseases, including Alzheimer's disease, alcohol abuse, depression, anxiety and epileptic behavior, and relieves the damaged autophagy process in neurons in the hippocampus. Improve brain function, etc.
Other effects
Dihydromyricetin can significantly enhance the body's antioxidant capacity, inhibit hyperlipidemia, and can lower blood sugar and improve insulin sensitivity in various types of diabetes. Dihydromyricetin can also protect liver cells, resist liver fibrosis, reduce liver damage, and resist cirrhosis.
Dihydromyricetin can reduce endotoxemia kidney damage molecules and blood urea levels, reduce malondialdehyde content and calcium ion concentration in renal tissue, and alleviate acute kidney injury. Dihydromyricetin can significantly reduce calcium oxalate crystals and lumen expansion, and also has a certain preventive and therapeutic effect on kidney stones.
The combination of dihydromyricetin and myricetin has anti-hepatitis B virus, influenza virus and coronavirus effects.
How to improve bioavailability?
Dihydromyricetin uses high-stable binding and inclusion technology to target dihydromyricetin into the hydrophobic inner cavity of β-cyclodextrin, while the hydrophilic outer shell of β-cyclodextrin ensures its Compatible with water-based systems. After treatment with inclusion technology, dihydromyricetin obtains a hydrophilic shell, which can form a molecular emulsion in water that is more easily absorbed by the human body. In addition, the use of high-stable microemulsification technology makes dihydromyricetin more stable in the alkaline intestinal environment.
High solubility: The solubility of Dihydromyricetin in cold water can reach about 20mg/mL. Compared with the raw material, the water solubility is increased by 28.6 times. After dissolution, the solution is clear and translucent. In addition, static precipitation experiments showed that the retention rate of Dihydromyricetin was 98.9% after being stored in an acidic aqueous solution for 12 months. High solubility and resistance to precipitation can meet the shelf life stability requirements of dihydromyricetin beverages.
Product Application
Dihydromyricetin powder is currently widely used as a health product, and it also has good neuroprotective activity against alcohol addiction.
DMY is a plant flavonoid compound with extremely high medicinal value. As a new product with low toxic and side effects, its application range is extremely wide, mainly reflected in its antioxidant, antibacterial, hangover, liver protection, hypoglycemic and other medicinal effects. aspects, but the pharmacokinetics research is not systematic and in-depth enough.
Extraction Method
A method for extracting dihydromyricetin from rattan tea, specifically including the following steps:
(1) Soak the dried leaves of rattan tea in solvent;
(2) Filter and subject the wet rattan tea leaves to microwave radiation treatment;
(3) Combine the filtrate with the microwave-irradiated rattan tea leaves, and heat and extract in a water bath;
(4) Filter while hot, and the filtrate will crystallize and separate.
The solvent described in the above step (1) is water or ethanol; the solid-liquid ratio of the above-mentioned dried rattan leaves and the solvent is 1:12-20g/ml, the solid-liquid ratio is 1:20g/ml, and the solvent is water.
The microwave treatment time in the above step (2) is 1 to 3 minutes; the microwave treatment time is 3 minutes, and the microwave power is high-grade, that is, 900W.
The water bath heating time in the above step (3) is 30 to 120 minutes, the water bath temperature is 60 to 90°C; the water bath heating time is 120 minutes.
Test Report
ITEM | STANDARD | TEST RESULT |
Assay(HPLC) | ≥98.0% | 98.43% |
Physical & Chemical | ||
Appearance | White powder | Complies |
Partical Size | 95% pass 80 mesh | Complies |
Loss on Drying | ≤5.0% | 1.24% |
Ash Content | ≤1.0 % | 0.31% |
Heavy Metal | ||
Total Heavy Metals | ≤10ppm | <10ppm |
As | ≤2.0ppm | <2.0ppm |
Pb | ≤2.0ppm | <2.0ppm |
Cd | ≤0.5ppm | <0.5ppm |
Hg | ≤1.0ppm | <1.0ppm |
Microbiological Test | ||
Total Plate Count | ≤1,000cfu/g | <10cfu/g |
Mold and Yeast | ≤100cfu/g | <10cfu/g |
E.Coli | ≤10cfu/g | <0.3cfu/g |
Salmonella | Negative | Negative |
Staphylococcus | Negative | Negative |
Conclusion | Conform with specification | |
Storage | Store in cool and dry places. Keep away from strong light and heat | |
Packing | 1kg/Bag | |
Shelf Life | 24 months under the above condition,and in it's original package | |
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Company introduction and certificates obtained
Shaanxi Yuantai Biological Technology Co., Ltd. was established in 2014, mainly supplying Dihydromyricetin powder, etc. We have our own factory, R&D and quality inspection team, and have the conditions for development, production and sales. quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.
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