As a competitive tyrosinase inhibitor, deoxyarbutin can regulate the production of melanin, overcome pigmentation, lighten dark spots on the skin, and has a rapid and long-lasting skin whitening effect. The inhibitory effect of deoxyarbutin on tyrosinase is obviously better than that of other whitening active agents, and a small amount of use can show whitening and brightening effect. Deoxyarbutin also has a strong antioxidant effect.
Function:
As a new generation of cosmetic brightening and whitening active agent, deoxyarbutin is mainly used in high-grade whitening cosmetics.
Arbutin is one of the derivatives of arbutin, known as D-arbutin, which can effectively inhibit the action of tyrosinase in skin tissue. According to research, its effectiveness is even 10 times that of hydroquinone. 350 times that of general arbutin. In animal skin tests, this D-Arbutin can quickly and effectively whiten the skin, and after stopping use, the effect can still be maintained for nearly 8 weeks.
In human clinical research, topical application of D-Arbutin for 12 weeks can obtain obvious skin lightening effect, and it has a good improvement effect on solar sun exposure spots and dull skin conditions.
The clinical research on D-Arbutin further pointed out that in the past, many kinds of tyrosinase inhibitors were used to reduce skin lesions with melanin accumulation. D-Arbutin produced by QSAR (quantitative structure-activity relationships) technology is a very effective The unique tyrosinase inhibitory ingredients have a significant blocking effect on the formation of melanin in the skin. According to the test results of human skin melanocytes, in the case of keeping 95% of the cells alive, the safe concentration of D-Arbutin used can be more than 4 times that of hydroquinone, which means that D-Arbutin is more toxic to melanocytes than Hydroquinone is much safer. Furthermore, experiments on human skin keratinocytes (the main cells of the epidermis) and fibroblasts (the dermis) indicate that D-Arbutin is still much less toxic to cells than hydroquinone. What needs to be made clear to everyone is that compared with hydroquinone in terms of the effectiveness of inhibiting melanin formation, D-Arbutin can achieve a higher concentration than high-concentration hydroquinone at a relatively low concentration effect.
When the use of D-Arbutin is stopped, the tyrosinase activity and melanin content in the skin will slowly recover, which means that D-Arbutin will not cause the poisonous effect of melanocytes, and can still maintain the normal physiological mechanism of melanocytes. . In an 8-week clinical study, topical application of D-Arbutin resulted in gradual but noticeable skin lightening effects. Another clinical study also pointed out that using D-Arbutin solution at an appropriate concentration, good clinical effects can be obtained within 3 weeks. And according to the experiment, the effect of D-Arbutin against melanin can reach 10 times that of hydroquinone, 150 times that of kojic acid, and 350 times that of general arbutin (β-arbutin). If you compare it with the popular α-arbutin If it is, it is 38.5 times of it.
Effection:
It has anti-oxidation, lowering blood fat, improving cardiovascular health, protecting eyesight, etc.
1. Antioxidant effect: DeoxyArbutin has a strong ability to scavenge free radicals, which can reduce cell damage caused by free radicals generated in the oxidation process, and plays an important role in preventing human aging, improving immunity, and preventing various diseases.
2. The effect of lowering blood fat: DeoxyArbutin can promote fat metabolism, reduce blood cholesterol and triacylglycerol content, and help improve dyslipidemia and obesity.
3. Improve cardiovascular health: DeoxyArbutin can improve the function of vascular endothelial cells, reduce damage to blood vessel walls, reduce the risk of arteriosclerosis, and help prevent heart disease, high blood pressure and other diseases.
4. Protect vision: DeoxyArbutin can inhibit the apoptosis and oxidative stress of retinal cells, and has a certain protective effect on improving vision and preventing eye diseases such as glaucoma and cataract.
In addition to the above effects. DeoxyArbutin also has certain anti-inflammatory effects. In general, deoxyArbutin has a wide range of functions and effects, but it should be consumed in moderation to avoid discomfort to the body.
Safety performance: A comparative test of various whitening active agents shows that deoxyarbutin has the lowest cytotoxicity, and its skin lightening effect is reversible, so it is considered to be a very safe cosmetic whitening active agent. For specific research and test results, please refer to the relevant research reports of deoxyarbutin.
How to use: Deoxy arbutin, oil-soluble, easily oxidized when exposed to water.
Suggestion: Add 0.3%-3% to oil with a pH value between 6-8, preferably as a lotion or cream. But it should be noted that there is no water in the lotion cream.
Note: Deoxyarbutin is insoluble in water, but it is very easy to change color in an aqueous system. Even with a small amount of water, it will turn red and then dark brown after being placed. Pay attention to the formula:
1. Nitrogen filling;
2. Add antioxidants that can be compounded.
3. The heating temperature should not be higher than 80°C, and it is better to add it to the low temperature phase.
4. Fully study the formula to eliminate the effect of discoloration.
Storage and transportation: Sealed and stored in a dry place at low temperature and away from light.
Storage: This product should be sealed and stored in a dry place at low temperature.
Avoid contact with strong acids and alkalis.
If you would like to learn more, please contact sales@sxytbio.com，Click here to contact us online
