What is Palmitoyl Hexapeptide-12?
Palmitoyl hexapeptide-12 is a lab-made peptide that mixes the fatty acid palmitic acid with several amino acids, including glycine, histidine, and lysine. Combining this specially designed peptide with palmitic acid enhances its penetration into the skin as well as the stability of the peptide.
Palmitoyl hexapeptide-12 In the early days of skin care peptides, it was called palmitoyl oligopeptides. The amino acid sequence of this peptide mimics the amino acid sequence of peptides naturally occurring in the skin, which means the skin can recognize it and easily utilize it.
Palmitoyl hexapeptide-12 works on the top and outermost layers of the skin by affecting key support elements in the skin, making the surface of the skin firmer and minimizing the appearance of wrinkles. It also strengthens the skin's barrier by improving moisture, leaving skin feeling soft rather than rough. As a signaling peptide, it can make skin look younger.
Palmitoyl hexapeptide-12 is a signaling peptide that is particularly implicated in repairing age-related skin damage. The hexapeptide fragment is repeated as many as six times in the entire molecular structure of elastin, hence the name "spring fragment". Palmitoyl hexapeptide-12 has a chemotactic effect, which can promote the migration and proliferation of dermal fibroblasts and the synthesis of matrix macromolecules (such as elastin, collagen, etc.) to provide support for the skin. It can also induce fibroblasts and monocytes to specific locations for wound repair and tissue renewal.
It has good surface activity, can improve the bioavailability of hydrophobic nitrogen oxides, and stimulate the degradation of nitrogen oxides, because it can be fused with heavy metals, so it can remove heavy metals from environmentally contaminated soil layers and deposits. Therefore, it is a key biological surfactant.
It also has a unique biological activity, such as enhancing the activity of urokinase, to avoid blood clotting, most of the lipopeptide also have antibacterial effect, so it is also called antibacterial, lipopeptide biological surfactant because of its unique chemical composition and amphiphilic molecular formula, in the cosmetics and microbial oil extraction industry has a key application prospect.
[Product composition] : Palmitoyl hexapeptide-12
[Product specification] : 98%
[Detection method] : HPLC
[Product appearance] : white powder
[Storage conditions] : Store in a cool and dry place, away from light and high temperature.
Warranty period: 24 months
[Product source] : synthetic
Benefits for the skin?
anti-wrinkle
Palmitoyl hexapeptide-12 has a similar function of inhibiting neurotransmitters, blocking the transmission function between neuromuscles, slowing the conduction function between muscles, slowing the intensity of muscle contraction, relaxing muscles, reducing the appearance of moving lines, and eliminating wrinkles.
chemotaxis
Palmitoyl hexapeptide-12 has a chemotactic effect, which promotes migration, proliferation and matrix macromolecule synthesis (such as elastin, collagen, etc.). Dermal fiber cells and provide support for the skin. It can also promote fibroblasts and monocytes to reach specific locations for wound repair and tissue renewal.
Increase collagen
Effectively reorganizes collagen elasticity, increases elastin activity, relaxes facial lines, smooths wrinkles and improves relaxation. It can be used in cosmetics as an anti-wrinkle ingredient with excellent results.
Product application
cosmetics
Palmitoyl hexapeptide-12 has similar inhibition of nerve conduction substances, block the conduction function between neuromuscles, avoid excessive muscle contraction, can prevent the formation of fine lines, can slow down the force of muscle contraction, let the muscle relax, reduce the occurrence of dynamic lines and eliminate fine lines; Effective re-organization of collagen elasticity can increase the activity of elastin, relax facial lines, smooth wrinkles and improve relaxation. Can be used in cosmetics as an anti-wrinkle ingredient, and the effect is excellent.
Degraded residual pesticide
Adding lipopeptide biosurfactants or surfactant-producing bacteria to soil contaminated with pesticides can significantly degrade harmful components. The degradation rate of endosulfan was increased by 30% ~ 45%. It is used to inhibit plant pathogens. Experiments show that it can be used as a biological control agent to replace chemical insecticides, so that the organic waste of food industry can be transformed into organic waste with biological insecticide effect by bacteria, and organic waste recycling can be effectively realized. Different strains of Bacillus subtilis can also produce Bacillus antimycin analogues, which also have strong antifungal activity.
Antiviral effect
The inactivation efficiency of palmitoyl hexapeptide-12 was higher than that of non-lipo-coated viruses, especially herpes virus and retrovirus. Its mechanism of action is that it can interact with phospholipids on the cell membrane to form ion channels, thus inhibiting the activity of many enzymes; Surfactants can also interact with the viral lipid membrane to destroy the viral lipid membrane and capsid, thus showing antiviral, anti-tumor, anti-mycoplasma, anti-fungal and to some extent anti-bacterial activities.
It can be used as a biological control agent to replace some chemical pesticides, and can effectively inhibit the harm of pathogens to tomatoes. Different strains of Bacillus subtilis can also produce Bacillus antimycin analogues, which also have strong antifungal activity. The lipopeptide antibiotics produced by Bacillus subtilis B2 strain can be used to control soft rot of Chinese cabbage and sclerotium rot of rape.
Microbial oil recovery technology,
Microbial oil recovery is an important application field of biosurfactants. In oil field exploitation, about 70% of the crude oil remains in the reservoir after one production. Enhanced oil recovery can increase the oil recovery rate to 80%-85%. Using biosurfactants to flood oil will not pollute the environment. A lipopeptide biosurfactant produced by Bacillus licheniformis can survive at 120 ℃ under the condition of pH 4 ~ 12 and mass concentration of calcium ion 4000 mg/L. These characteristics are conducive to the use of this product in oil production and transportation.
4.Specification parameter
Palmitoyl hexapeptide-12 is a synthetic peptide that mixes the fatty acid palmitic acid with several amino acids, including glycine, histidine, and lysine. By combining this specially designed peptide with palmitic acid, palmitoyl hexapeptide-12 is formed.
5.Industry development prospect
People pay more attention to skin whitening care, as a cosmetic raw material, palmitoyl hexapeptide-12 wound repair ability and tissue renewal ability is very strong, and can remove wrinkles, without any side effects.
People use a lot of pesticides in order to deworm their crops, and a lot of land is destroyed because of pesticide residues, and palmitoyl hexapeptide-12 can degrade residual pesticides and remove heavy metals from the soil. Play a role in protecting the environment. So its market demand will continue to increase, there are good prospects for development.
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