β-sitosterol is an organic compound, the molecular formula is C29H50O, is a white crystalline solid, widely found in nature in a variety of vegetable oils, nuts and other plant seeds, but also exists in some plant drugs.
sterol is a kind of steroid which exists in nature, although the content is not much, it has high application value. Because it's solid and calls it sterols it's a macromolecular alcohol. It is the main component of unsaponifiable substances in oils and fats. According to the different sources, sterols can be divided into three categories, namely animal sterols, plant sterols and bacterial sterols.
Phytosterols (sitosterols) are considered to be mild free radical scavenger, which to some extent explains the positive effects of phytosterols in maintaining cell membrane stability, inhibiting inflammation, preventing atherosclerosis and anti- cancer. Anti-inflammatory and immunomodulatory effects Phytosterols have anti-inflammatory, anti-infection and inhibition of bacterial and fungal reproduction, and their anti-inflammatory effects are also one of the earlier discovered functions.
The characteristics of both sexes make it have the ability to nodal and control the flow of reverse phase film. On the other hand, plant sterols are mainly hydrophobic, but because of its structure with hydroxyl set group, so it has a certain hydrophilicity, the larger the side chain, the stronger the hydrophobic sterols, the specific gravity of plant sterols is slightly larger than water, insoluble in water, soluble in a variety of organic solvents.
Applications:
Phytosterols have a wide range of biological functions in medicine and food science. In animal production, the scientific use of plant sterols can promote the growth of animals, improve the health of the organism, improve the quality of animal products, and play a positive role in reducing the breeding cost and increasing the economic benefit. As a functional additive, phytosterols have broad application prospects in feed industry. At present, the mechanism of action, effective dosage form and dosage, absorption efficiency and application technology of plant sterols to improve animal growth and health have not been fully clarified, and a large number of in-depth studies are needed to lay a foundation for its scientific and rational application. β-sitosterol and β-sitosterol derivatives are widely used in medicine, food, cosmetics, feed and other industries because of their unique biological and physicochemical properties.
It has the effects of lowering cholesterol, relieving cough, expelling phlegm, inhibiting tumor and repairing tissue. It is used for type II hyperlipidemia, atherosclerosis and chronic bronchitis, and also for early cervical cancer and skin ulcers. Large doses of can cause loss of appetite, diarrhea, gastrointestinal pain and other gastrointestinal reactions. Ulcers caused by osteomyelitis should not be used before the primary disease has healed. Lower leg ulcers with lower limb varicose veins must be treated at the same time.
Preparation method
Rice bran oil is used as raw material
Raw material treatment: Take methine soap residue and dry it in the oven at a constant temperature below 80℃, so that the water content is less than 2%, and the dry soap residue is small particles or powder.
Extraction: Take the dry soap residue and add it to the enamel reaction tank, add acetone (V soap residue: V acetone = 1:8), stir it, heat it with the distillation steam in the clip, extract it by reflux at 50-55℃ for 3-4h, cool it to 30℃ and discharge the material, stand at 10-15℃ for 12h, press filter to obtain the filtrate.
Concentration, crystallization and drying: Put the filtrate into the concentration tank, concentrate to 1/5 of the original volume, obtain the concentrated liquid, stand at room temperature for crystallization for 12h, filter, obtain rough products, drying in the oven at 60℃, and dry rough products.
Decolorization, crystallization, drying: Take the dry coarse product and add 25-30 times 95% ethanol, add hydrochloric acid to adjust pH3-4, heat the water bath, dissolve the coarse product, add 10-20g/L activated carbon to gently boil for 20min, filter while hot, obtain the filtrate, stand at room temperature and crystallize for 12h, until the crystallization is complete, filter, collect the crystalline product, and dry under 80℃ vacuum to obtain the sitosterol product.
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