Description
kojic acid dipalmitate is a chemical substance with the molecular formula C38H66O6. It is a white powder or needle-shaped crystal and is mainly used as a whitening additive in cosmetics.
Product performance: It is a fat-soluble derivative of kojic acid. It not only overcomes the shortcomings of kojic acid's instability to light and heat and discoloration when exposed to metal ions, but also does not interact with cosmetic systems due to the absence of hydroxyl groups in its molecular structure. The preservatives, sunscreens or other active ingredients in the product form hydrogen bonds and affect the efficacy of these additives. It has excellent compounding properties. As a fat-soluble additive in cosmetics, in addition to being easier to formulate, it can also be more effectively absorbed by the skin and bring good moisturizing effects to the skin.
Skin care benefits of kojic acid dipalmitate
1) Whitening: Kojic acid dipalmitate is more effective than kojic acid in inhibiting the activity of tyrosinase in the skin, thereby inhibiting the formation of melanin, and has a good effect on skin whitening and sun protection.
2) Freckle removal: Kojic acid dipalmitate can improve skin pigmentation and can combat age spots, stretch marks, freckles and general pigmentation.
Kojic Acid Dipalmitate Cosmetic Compounding Guide
Kojic acid dipalmitate is difficult to incorporate into formulations and can easily form crystal precipitates. In order to solve this problem, it is recommended to add isopropyl palmitate or isopropyl myristate to the oil phase containing kojic acid dipalmitate, and heat the oil phase to 80°C and keep it warm for 5 minutes until the kojic acid dipalmitate is reached. The palmitate is completely dissolved, then add the oil phase to the water phase and emulsify for about 10 minutes. Usually the pH value of the final product obtained is around 5.0-8.0.
The recommended dosage of kojic acid dipalmitate in cosmetics is 1-5%; the dosage in whitening products is 3-5%.
Outlook: The kojic acid dipalmitate market research report statistics the market data of the past five years and predicts future market development prospects. According to statistics, the global and Chinese kojic acid dipalmitate markets will have market sizes of 100 million yuan (RMB) and 100 million yuan respectively in 2022. Through in-depth analysis of market growth patterns, the report makes an objective prediction of the future change trends of the kojic acid dipalmitate market. According to the report, the market size of kojic acid dipalmitate is expected to reach 100 million yuan in 2028.
The product price trend, sales volume and market share of the kojic acid dipalmitate industry are analyzed from the perspective of kojic acid dipalmitate product types; in terms of application, the report analyzes the market size and market size of the kojic acid dipalmitate industry in different application fields. Development. In addition, the report includes an analysis of the main raw material supply status and major suppliers in the upstream market of the kojic acid dipalmitate industry, as well as an analysis of the demand, sales volume and growth potential of each downstream market. The report also includes an analysis of the import and export trade situation of China's kojic acid dipalmitate market, including import and export trade volume, trade value, and analysis of major import and export countries and regions. Demand has been consistently rising.
Test Methods
3.1 Principle: Use the mobile phase - methanol and 1% acetic acid aqueous solution (10:90) as the solvent, ultrasonic extraction, centrifugation, filtration with a 0.45x.m filter membrane, and inject the solution into a liquid chromatograph equipped with a diode array detector (DAD) for detection. , Quantification by external standard method.
3.2 Reagents and materials: Unless otherwise specified, all reagents used are of analytical grade. The water is first-class water specified in GB/T 6682.
3.2.1 Methanol: chromatographically pure.
3.2.2 Kojic acid; purity not less than 98%.
3.2.3 Acetic acid.
3.2.41% acetic acid aqueous solution: Take 10 mL of glacial acetic acid and adjust the volume to 1 000 mL.
3.2.5 Mobile phase: methanol: 1% acetic acid aqueous solution - 10:90.
3.2.6 Kojic acid standard stock solution: Accurately weigh 0.1 g (accurate to 0.000 1 g) of kojic acid in a 50 mL beaker, add 1% acetic acid aqueous solution to dissolve it, transfer it to a 100 mL volumetric flask, and use 1% acetic acid aqueous solution to dissolve it. Dilute the acetic acid aqueous solution to the mark to obtain a standard stock solution with a concentration of kojic acid solution of 1 000 mg/L. Store in a sealed and cool place for 3 months.
3.2.7 Standard working solution: Pipette 0.2 mL, 0.5 mL, 1.0 mL, 2.0 mL, and 5.0 ml of the standard stock solution (3.2.6) into five 10 mL volumetric flasks, and use the mobile phase (3.2.5) to Bring the volume to the mark and prepare a series of standard working solutions with concentrations of 0.02 mg/ml., 0.05 mg/mL, 0.1 mg/ mL, 0.2 mg/L, and 0.5 mg/L.
3.3 Instruments and equipment
3.3.1 High performance liquid chromatograph equipped with diode array detector.
3.3.2 Micro sampler, 10 L.
3.3.3 Ultrasonic cleaner.
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