Formononetin

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of formononetin in China. With abundant experience, we warmly welcome you to wholesale bulk formononetin for sale here from our factory. Quality products and reasonable price are available.

Formononetin is an isoflavone compound, which is widely found in leguminous plants such as Astragalus, Licorice, Pueraria, and Trifolium eryngii. Its chemical properties are white crystalline powder, which is easily soluble in methanol, ethyl acetate, ether and dilute alkaline solution, but difficult to dissolve in water.
Formononetin is mainly derived from leguminous plants, such as the root of Astragalus, Licorice, Pueraria, and Trifolium eryngii. It can also be extracted from the inflorescence and flowering branches and leaves of the leguminous plant Trifolium eryngii, as well as the whole herb of Ononis spinosa.

Modern pharmacological research shows that formononetin has anti-tumor, hypolipidemic, anti-arrhythmic, antibacterial, antispasmodic, anti-lipid peroxidation, estrogen, etc. effects, can improve atherosclerotic lesions, and can also scavenge oxygen. It has the effects of inhibiting free radicals and inhibiting the proliferation of vascular smooth muscle cells. It is widely used in clinical practice and has remarkable curative effects.

‌Formononetin has a variety of health benefits, including anti-cancer, regulating hormone levels, anti-inflammatory, antioxidant, anti-apoptotic, regulating blood lipids and anti-thrombotic effects‌‌.

hormone regulation
Formononetin has estrogen-like effects and can regulate hormone levels in the body in both directions, especially in the treatment of diseases caused by estrogen deficiency. High doses of formononetin have estrogen-like effects in the body and have certain safety on the reproductive system.

Cardiovascular and cerebrovascular protection
Formononetin can significantly reduce the levels of cholesterol, triglycerides and low-density lipoprotein cholesterol in the blood, while increasing the content of high-density lipoprotein cholesterol. It has the effect of regulating blood lipid metabolism in the body, thereby protecting the cardiovascular and cerebrovascular systems. system.

Anti-inflammatory, antioxidant and anti-apoptotic effects
Formononetin also has anti-inflammatory, antioxidant and anti-apoptotic effects. It can reduce cellular lipid peroxides, scavenge oxygen free radicals, and protect cells from oxidative stress damage.

Clinical application potential
Formononetin has made great progress in experimental research and has broad clinical application potential. It can be used to treat various diseases such as cardiovascular and cerebrovascular diseases, tumors, diabetes and its complications.

The effect of formononetin on upregulating SR-BI protein expression and affecting blood lipid metabolism, liver steatosis and atherosclerotic lesions was studied. The transcriptional activation effect of formononetin on CLA-1/hSR-BI protein gene was evaluated by high-throughput screening model. The experimental hyperlipidemia animal model was established by feeding golden hamsters with high-fat diet for 21 days. Different doses of formononetin were given, and the plasma total cholesterol (TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C) levels were measured 28 days later. Tissue sections were HE stained to observe liver lesions and thoracic aortic sclerosis.

Results: Formononetin can reduce serum TC, TG and LDL-C in hyperlipidemic golden hamsters to a certain extent, increase HDL-C; improve liver steatosis, reduce inflammatory cell infiltration; inhibit the formation of subintimal foam cells and medial smooth muscle hyperplasia of the thoracic aorta wall. Conclusion: Formononetin has the effects of regulating blood lipid metabolism, inhibiting liver fat deposition and preventing atherosclerosis.

The stability of vascular smooth muscle cells (VSMCs) function is a necessary condition for blood vessels to maintain normal physiological functions. Under normal circumstances, the vascular media SMCs are in a dedifferentiated state, with low cell proliferation and extracellular matrix secretion capabilities. In addition, the barrier function of the intact endothelium makes them almost unresponsive to peripheral circulating cytokines and growth factors. After atherosclerosis or angioplasty, the vascular endothelium is damaged, and the media SMCs are exposed to various stimuli, which enhances their proliferation and migration capabilities and synthetic functions, thereby promoting the formation of new intima, which becomes the pathological basis of intimal hyperplastic vascular diseases. Thrombin is an important medium that promotes this pathological process.

YTBIO mainly supplies Formononetin etc. The company was established in 2014 and has many years of R&D and production experience. We are committed to the research and development, production and sales of raw materials for the 21st century health industry. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA,etc. We always maintain the highest requirements for product quality.

Hot Tags: formononetin, China formononetin manufacturers, suppliers, factory