L-glutathione Powder

What is glutathione?

L-Glutathione powder (GSH) is a tripeptide composed of glutamic acid, cysteine and glycine, and contains sulfhydryl groups. Glutathione (GSH) has antioxidant and comprehensive detoxification effects. The sulfhydryl group on cysteine is the active group of glutathione (so glutathione is often called g-SH), which can easily interact with some drugs (such as paracetamol) and toxins (such as free radicals, iodoacetic acid, mustard gas) combined. , lead, mercury, arsenic and other heavy metals), it has a comprehensive detoxification effect. Therefore, glutathione, especially in liver cells, is involved in biotransformation, converting harmful toxins into harmless substances and excreting them from the body. Glutathione also helps maintain normal immune system function

Glutathione mainly exists in two forms: reduced glutathione (GSH) and oxidized glutathione (GSSG). Due to its good antioxidant and immunomodulatory effects in the body, it is widely used in food, medicine, cosmetics and other fields. As one of the essential nutrients for the human body, it has been widely used to treat diseases such as vitamin deficiency, malnutrition syndrome and low immune function caused by various reasons. It has also been proven to be of great significance in the anti-aging process.

Glutathione (GSH) is a tripeptide that is produced endogenously in the human body. Glutathione is found in the cells of animals and plants and is the antioxidant substance with the highest concentration in cells. For the human body, glutathione plays an extremely important role in maintaining the integrity and healthy operation of cells. An endless supply of glutathione plays an important role in intracellular antioxidant, free radical scavenging, detoxification and other functions. Indispensable element for operation.

Glutathione is a highly respected dietary supplement in today's health food industry. The cosmetics industry also highly recommends glutathione, mainly because of its whitening, antioxidant and heavy metal chelating functions. There is no upper limit on the amount of glutathione added to skin care products.

We have ten years of experience in the field of plant extracts and cosmetic raw materials. We have our own factory, and for our cooperation to be more convenient and fast, we have set up branches in Europe and the United States, which can deliver faster and more favorable s price

As a glutathione powder supplier(glutathione wholesale supplier), we supply pure glutathione powder (glutathione reduced powder). Regarding l glutathione powder, we can supply all products in the glutathione series. If you need wholesale glutathione, our initial cooperation may start with bulk glutathione , and all of our products support third-party testing.

What are the benefits?

redox activation

Reduced Glutathione exists in the tissues of the body, and it easily transfers H+ to the hydrogen acceptor to produce a reduction effect. It becomes oxidized Glutathione itself, and then is reduced to reduced Glutathione by NADPH in the tissue, so it plays an important role in the redox effect of the organism. Role.

enzyme activation

After SH-containing enzymes (Carboxylase, Monoaminoxydase, Transaminase, Lipase Trypsin, etc.) are oxidized, most of them become inactive S-S type. The S-S type enzyme is reduced to -SH type and is activated again.

Effect on patients with liver disease

Liver disorders can cause various metabolic disorders. Glutathione is related to metabolism and can improve liver dysfunction caused by liver disorders.

Anti-allergic effect

Allergic symptoms occur due to the intervention of chemical intermediary substances such as Histamine, Acetylcholine, Serotonin, Bradykinin, etc.

anti-oxidation

Glutathione is a natural reducing agent in living organisms and can be easily oxidized into GSSG, thereby protecting other substances from being oxidized. It can scavenge free radicals in the body, such as hydrogen peroxide, peroxide free radicals, etc., and protect sulfhydryl groups in proteins from being oxidized. It is oxidized, repairs the sulfhydryl groups in the damaged protein, restores the active function of the protein, prevents cell hemolysis, promotes the reduction of methemoglobin, and relieves discomfort caused by hypoxemia, nausea and liver disease.

Detoxify

Glutathione has a certain detoxifying effect on the poisoning of carcinogens such as carbon monoxide, heavy metals, organic solvents, and epoxy compounds, and can be combined with them to be excreted from the body; it also has an effect on leukopenia caused by radiation, radioactive drugs, or anti-tumor drugs. It has a protective effect; it also has a detoxifying effect on various carcinogens by helping the liver metabolize, such as aflatoxin, etc.

Prevention and treatment

Glutathione can be used to protect the liver and promote liver detoxification. It is often used to treat liver diseases such as alcoholism, cirrhosis, hepatitis, and fatty liver. Long-term use of glutathione can inhibit the formation of alcoholic fatty liver.

Glutathione is also beneficial to the maintenance of corneal and lens transparency, tissue repair and regeneration, and can also be used to treat progressive cataracts, corneal diseases and retinal diseases.

Whitening

Glutathione can reduce tyrosinase activity in three different ways.

1. Tyrosinase is directly inhibited by sulfhydryl chelating copper sites.

2. Glutathione interferes with the cellular transfer of tyrosinase to promelanosomes, which are a prerequisite for melanin synthesis.

3. Third, the inhibition of tyrosinase is achieved indirectly through its antioxidant effect. Glutathione transfers melanogenesis from eumelanin to pheomelanin synthesis via a reaction between sulfhydryl groups and dopaquinone, resulting in the formation of sulfhydryl-dopa conjugates. Glutathione has powerful antioxidant capabilities and has been shown to scavenge the production of reactive oxygen species in epidermal cells induced by ultraviolet radiation.

Enhance enzyme activity

Glutathione protects the -SH group in the enzyme molecule, which is beneficial to the enzyme activity, and can restore the active function of the -SH group in the enzyme molecule that has been destroyed, so that the enzyme can regain its activity. Glutathione can also inhibit fatty liver caused by ethanol's damage to the liver.

Protect blood cells

Glutathione can also protect hemoglobin from oxidation such as hydrogen peroxide and free radicals, allowing it to continue to function normally in its ability to transport oxygen. Human red blood cells contain a lot of glutathione, which is of great significance for protecting the sulfhydryl groups of proteins on red blood cell membranes from being in a reduced state and preventing hemolysis.

Fight free radicals

Excessive free radicals produced by the body's metabolism will damage biological membranes, attack life macromolecules, and accelerate the aging of the body. The main physiological function of glutathione is to remove free radicals in the human body. As an important antioxidant in the body, it protects the body. Sulfhydryl groups in many molecules such as proteins and enzymes.

Adding glutathione to food can play an unexpected role:

1. Adding to noodle products can play a reducing role. It not only shortens the time for making bread to one-half or one-third of the original, but also greatly improves the working conditions, and plays a role in strengthening food nutrition and other functions.

2. Add it to yogurt and baby food, which is equivalent to vitamin C, which can act as a stabilizer

3. Mix it into the fish cake to prevent the color from deepening.

4. Adding to meat products and cheese and other foods has the effect of intensifying flavor

The whitening mechanism of glutathione:

Reduced l glutathione powder can reduce tyrosinase activity in three different ways. Tyrosinase is directly inhibited by sulfhydryl chelating copper sites. Secondly, glutathione interferes with the cell transfer of tyrosinase to premelanosomes, which is a prerequisite for melanin synthesis. Third, the inhibition of tyrosinase is achieved indirectly through its antioxidant effect. Glutathione transfers melanogenesis from eumelanin to pheomelanin synthesis through the reaction between sulfhydryl and dopaquinone, resulting in the formation of sulfhydryl-dopa conjugates. Glutathione has a strong antioxidant capacity and has been proven to eliminate the reactive oxygen species produced in epidermal cells induced by ultraviolet radiation.

Product Application

Skin care products field

Glutathione is well known for its benefits as a skin care product. As an antioxidant factor, GSH has the spirit of "giving up the small self for the greater self". It is actively oxidized by free radicals and converted into inactive GSSG, which is degraded by macrophages, thus protecting the integrity of cells. Not only that, when it comes to fighting melanin, glutathione also has its own unique mechanism of action, which can block the activity of tyrosinase and achieve whitening effects from the root. In addition, it has the effect of repairing damaged cells and improving the delicateness and smoothness of the skin.

Medical beauty field

Glutathione is the main ingredient in the medical beauty product "whitening injection". In addition, the medical beauty product "whitening injection" is mainly made of hyaluronic acid, glutathione and other products in a scientific ratio. It has whitening and anti-aging properties. Oxidation and inhibition of melanin. When adding glutathione ingredients to water-light injections, be sure to let a professional doctor do the mixing and operation. When injecting whitening injections, the ingredients are only injected into the dermis layer and cannot enter the muscle layer, making the treatment of deep dynamic lines ineffective and can only temporarily treat epidermal fine lines.

Health products

GSH can participate in biological transformation, excrete harmful substances from the body, help maintain normal immune function and other functions; protect your own liver, heart, etc.

Test Report

Flow Chart

Analysis Report

Determination of Content

1.1 Instrument and Equipment

High Performance Liquid Chromatography (HPLC)

Chromatographic Work Station (N2010)

1.2 The Condition of Instrument

Chromatographic Column: Ｃ18 150×4.6ｍｍ+ Guard Column

Column Temperature: 29.8℃

Flow Velocity: 0.8ml/min

Detection Wavelength: 214nm

Sample Amount: 20ul

1.3 Reagent and Solution

Trifluoroacetic Acid (TFA)

Acetonitrile(CH3CN)

Buffer Solution A: 0.1% TFA,H2O

Buffer Solution B: 0.1%TFA,CH3CN

Mobile Phase C: A:B=95∶5 (volume ratio)

1.4 Test methods

Sample and reference material of Glutathione Reduced Accurately weigh 0.25g

(accurate to 0.0002g) , add buffer A and dilute to 1000ml volumetric flask, and

perform liquid chromatography analysis within half an hour.

1.5 The results calculated

The content X1 (expressed in weight percent) is calculated according to formula (1)

In the formula,

A1-Sample absorption peak area,uv×s;

A2-reference material absorption peak area,uv×s;

m1-Weigh the sample in grams,g;

m2-Weigh the reference material in grams,g;

X2-Loss On Drying of sample,percentage by weight(%)

Company introduction and certificates obtained

YTBIO mainly supplies glutathion powder etc. The company was established in 2014 and has many years of R&D and production experience. We are committed to the research and development, production and sales of raw materials for the 21st century health industry. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA,etc. We always maintain the highest requirements for product quality.

Our packaging

Our packing method is 1KG/Aluminium bags, 25kg/drum

For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin

Our team

Our team is professional, and our business team has undergone strict and professional product training. To ensure that our customers have a good cooperation experience and all questions during the cooperation process can be answered in a timely manner.

Factory

Payment method

The payment methods we support are: T/T, VISA, XTransfer, Master Card, Western Union, Alibaba Payment, e-Checking, Online Bank Payment

Shipping method

We support shipping by sea, air, DHL, FedEx, TNT, UPS, EMS, SF

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