Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of glabridin powder in China. With abundant experience, we warmly welcome you to wholesale bulk glabridin powder for sale here from our factory. Quality products and reasonable price are available.
What is glabridin?
Glycyrrhiza glabra is extracted from the root of licorice. It is a compound that can whiten the skin by removing melanin. Glycyrrhiza glabra has been given the title of "whitening gold" because of its powerful whitening effect and has anti-aging effects.
Licorice powder is a flavonoid compound extracted from a precious plant called licorice. Glycyrrhizin is known as "whitening gold" because of its powerful whitening effect, which can eliminate free radicals and melanin in the skin. Glycyrrhiza glabra is one of the main flavonoids in Glycyrrhiza glabra. It shows a strong anti-free radical oxidation effect in the cytochrome P450/NADPH oxidation system, which can significantly inhibit the free radicals generated during the metabolic process in the body, thus avoiding the oxidation of sensitive biological macromolecules (low-density lipoprotein LDL) and DNA. ) and cell walls are oxidatively damaged by free radicals. Therefore, some pathological changes related to free radical oxidation, such as atherosclerosis and cellular senescence, can be prevented.
Glycyrrhizin is an isoflavone compound with outstanding whitening effect. Mainly derived from the root extraction of Glycyrrhiza glabra L. Licorice glabra is the beauty-preserving molecule in licorice and is often used as a high-end skin care ingredient.
The reason why glabridin is known as "whitening gold" is mainly because it is difficult to purify, has a low extraction rate, and the price of raw materials is comparable to gold. It is understood that this ingredient has an outstanding whitening effect, and the whitening effect is 140 times that of nicotinamide. Licorice can not only prevent darkening, but also help whiten the skin. It can be said to be a rare whitening ingredient that improves both internal and external effects.
If you want to eliminate melanin, you must first prevent the production of melanin and prevent the skin from darkening; secondly, you must accelerate the metabolism of the melanin that has been produced to make the skin "white back". General whitening ingredients can only act on a certain link of melanin production. Many products on the market require multiple ingredients to achieve a better whitening effect. As a single whitening ingredient, glabridin can achieve the effects of whitening the source, surface, middle, and middle layers. The bottom layer is full-link anti-darkness, with anti-darkness + anti-oxidation + anti-irritation effects.
The content of glabridin in Glycyrrhiza glabra is 1‰~3‰, and the content of total flavonoids in Glycyrrhiza glabra accounts for about 11%. Pure licorice is a white powder or white crystal, insoluble in water, and easily soluble Based on some organic solvents (acetone, toluene, ethanol), it is one of the indispensable cosmetic whitening raw materials in the Chinese market.
Molecular Structure
What are the benefits?
Whitening effect
The main whitening mechanism of glycyrrhizin is to competitively inhibit tyrosinase activity, taking part of the tyrosinase away from the catalytic loop of melanin synthesis, preventing the binding of the substrate to tyrosinase, thereby inhibiting the synthesis of melanin. synthesis.
Experiments have found that glabridin has an inhibitory effect on tyrosinase. The inhibitory IC50 value of glabridin on melanin is very low. The inhibitory effect of glabridin on melanin is 232 times that of vitamin C and 1164 times that of arbutin. , 16 times that of hydroquinone.
Comparing nicotinamide and VC ethyl ether, the absorbance is measured to reflect the inhibitory activity of tyrosinase. The results show that the effect on the inhibition rate of tyrosinase activity is: glabridin > nicotinamide > VC ethyl ether, among which glabridin The most significant impact.
The inhibitory ability of glabridin on DPPH was studied and compared with vitamin C.
DPPH free radical scavenging rate
The results are shown in the figure. When the molar concentration of vitamin C is 350 μM and 700 μM, the scavenging rates of DPPH free radicals are 40.65% and 54.19%, and the half inhibitory concentration (IC50) is 537 μM; while glabridin is at the molar concentration. At 30 μM and 60 μM, the scavenging rates of DPPH free radicals reached 52.77% and 98.35% (IC50 is 23.73 μM); this shows that the scavenging effect of glabridin on DPPH is far greater than that of vitamin C, that is, glabridin Has antioxidant properties.
Anti-inflammatory effect
Glabridin can reduce inflammation caused by ultraviolet radiation (sun exposure), chemical stimulation, etc., reduce cell death caused by inflammation, and at the same time reduce the collapse of inner skin cells caused by endotoxicity of cells after inflammatory death, playing an anti-aging effect and Reduces pigmentation caused by inflammation.
Guinea pigs were exposed to ultraviolet light to cause pigmentation, and then applied with a 0.05% glabridin solution. It was found that glabridin reduced skin inflammation caused by ultraviolet stimulation.
Antibacterial
The antibacterial ability of glabridin has been studied. The drug susceptibility test results show that glabridin has MIC (minimum inhibitory concentration) against the tested Staphylococcus aureus ATCC25923, Staphylococcus aureus ATCC29213, Enterococcus faecalis ATCC29212, and Escherichia coli ATCC25922. ) were 4 μg/mL, 4 μg/mL, 32 μg/mL and 256 μg/mL respectively, that is, glabridin has antibacterial activity against these tested standard strains.
Activity of glycyrrhizin and control drugs against Staphylococcus aureus, Enterococcus faecalis and Escherichia coli (μg/mL)
Inhibit tyrosinase activity
The main whitening mechanism of glycyrrhizin is to competitively inhibit tyrosinase activity, taking part of the tyrosinase away from the catalytic loop of melanin synthesis, preventing the binding of the substrate to tyrosinase, thereby inhibiting the synthesis of melanin. synthesis.
In 2014, Wang Ruixue and others from the Shanghai Institute of Pharmaceutical Industry compared three commonly used whitening agents, glycyrrhizin, nicotinamide and VC ethyl ether, in an article published in "Daily Chemical Industry", by measuring absorbance. Reflecting the inhibitory activity of tyrosinase, the results show that the order of effect of each whitening ingredient on the inhibitory rate of tyrosinase activity is: glabridin > nicotinamide > VC ethyl ether, among which glabridin has the most significant impact. .
Anti-aging:
Licorice has an anti-aging effect because it contains a large amount of vitamin C, which can replenish nutrients in the skin, prevent small wrinkles or fine lines from appearing on the skin epithelium, and help keep the skin in a youthful state. Glycyrrhizin has a strong free radical scavenging effect. Vitamin C, vitamin E and β-carotene are recognized as the three kings of antioxidants and anti-aging. Glycyrrhizin's anti-aging ability is equivalent to that of vitamin E, and it is a natural antioxidant. Oxidant, it is reported that its antioxidant effect is significantly better than BHA and BHT. There are reports in the literature that licorice can be used to reduce corticosteroids in infectious skin diseases and enhance the effects of steroids.
Product Application
1.Glycyrrhizin has excellent anti-inflammatory, antioxidant and anti-melanin formation effects, so it is used as an ingredient in various cosmetics and medical care products (such as facial creams, lotions, shower gels, etc.). It can be made into a whitening cream, and such patented products are already on the market.
Dosage: In cosmetics, in order to achieve the whitening effect, the patented recommended dosage of glycyrrhizin is 0.001-3%, preferably 0.001-1%. 1:10 with glycerol, add at low temperature. Topical glycyrrhizin can inhibit the formation of melanin. It has excellent tyrosinase inhibitory activity and can prevent skin tanning, line spots and sun spots. The recommended dosage is 0.0007-0.05%. Research shows that as long as 0.05% glabridin, 0.3% aloe vera powder, 1% nicotinamide, and 1% AA2G can inhibit melanin tyrosinase as high as 98.97%, if it is to suppress male hormones and treat acne, photon The dosage of glycyrrhizin is 0.01-0.5%.
2. in the field of medicine,Mainly used to reduce blood lipids and blood pressure products
Whitening lotion:
| Ingredient | Content(%) | Ingredient | Content(%) | |
| Phase A | Glabridin | 0.02 | MSH | 5.0 |
| Water | 2.0 | Propylene glycol | 7.0 | |
| Phase B | Dc5225c | 5.0 | Dc345 | 10.0 |
| Dc200 | 5.0 | |||
| Phase C | Water | Add to100 | M-68 | 2.0 |
| Azone | 0.5 | SIMULGEL EG | 2.0 | |
| Glycerin | 5.0 | Hyaluronic acid | 0.1 | |
| Fragrance | Appropriate amount | Preservative | Appropriate amount |
Whitening cream:
| Ingredient | Content(%) | Ingredient | Content(%) |
| Glabridin | 0.1 | Magnesium aluminosilicate | 0.5 |
| Xanthan gum | 0.5 | Hexadecanol | 1.0 |
| Stearin | 4.0 | Glycolic acid | 5.0 |
| Hydrogenated polyisobutene | 4.0 | Ammonium hydroxide | Ph value 4 |
| Preservative | 0.5 | Refined water | Add to 100 |
Whitening night cream0.7
| Ingredient | Content(%) | Ingredient | Content(%) |
| Glabridin | 0.003 | Glycerin | 5.0 |
| Stearic acid | 15.0 | Propylene glycol | 3.0 |
| Cetanol | 1.0 | Refined water | Add to 100 |
| 0.7 |
Product Details Table
| Product Name | Glabridin | CAS | 59870-68-7 |
| MF | C20H20O4 | MW | 324.3704 |
| Specification | 20% 40% 90% 98% | ||
| Solubility | Glabridin insoluble in water, soluble in butanediol, propylene glycol and other organic solvents | ||
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Company introduction and certificates obtained
YTBIO mainly supplies Glabridin powder, etc. The company was established in 2014 and has many years of experience in R&D and production. We are committed to the R&D, production and sales of raw materials for the health industry in the 21st century. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA etc. We always maintain the highest demands on product quality.
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