Beta Arbutin Powder

Product Introduce

Beta Arbutin powder can be prepared by three methods: plant extraction, cell culture and artificial synthesis. It can affect the formation of melanin by inhibiting tyrosinase. It can also accelerate the excretion and decomposition of melanin in skin cells through its own combination with tyrosinase, reduce pigmentation, lighten spots and freckles, and achieve Whitening effect.

Arbutin can be divided into α-type and β-type according to different structures. The chemical name of α-arbutin is 4-hydroxyphenyl-α-D-glucopyranoside, and the chemical name of β-arbutin is 4-hydroxyphenyl-β-D-glucopyranoside. α-Arbutin is the epimer of β-arbutin, and the direction of its glycosidic bond in space is opposite to that of β-arbutin (see the figure below for details).

For beta arbutin, we can achieve two specifications of hydroquinone ≤1PPM and ≤4PPM, and we have a very good price advantage

Product Details Form

What are the benefits of beta arbutin?

1. Beta Arbutin powder can quickly penetrate into the skin, effectively inhibit the activity of tyrosinase in the skin and block the formation of melanin without affecting the proliferation concentration of skin cells.

2. Accelerates the decomposition and excretion of melanin through the combination of itself and tyrosinase, thereby reducing skin pigmentation and removing pigmentation and freckles.

3. It does not produce toxic, irritating, sensitizing and other side effects to melanocytes, and also has the effects of emollient, guaiac, sterilization and synergistic anti-inflammatory.

4. It is one of the safest and most effective whitening raw materials popular in foreign countries, and it is also the most competitive skin whitening and freckle removing active agent in the 21st century.

Whitening mechanism

The content and distribution of melanin are the main factors that determine the depth of skin color. Melanin is produced in melanocytes in the basal layer of the skin epidermis. It is finally formed from tyrosine under the action of tyrosinase through a series of complex biochemical reactions. It is transferred from the basal layer to the outer layer of the epidermis from the inside out through synapses. Color the skin.

Tyrosinase has tyrosine hydroxylase activity (catalyzing tyrosine to produce dopa) and dopa oxidase activity (catalyzing dopa to produce dopaquinone). In the process of melanin formation, it serves as the main rate-limiting enzyme. Its activity determines the amount of melanin formed.

Arbutin is a tyrosinase inhibitor that can effectively inhibit tyrosinase activity without affecting cell proliferation concentration. It competes for the binding of dopa through its direct binding to tyrosinase. site, blocks the synthesis of dopa and dopaquinone, thereby interfering with melanocytes and inhibiting the production of melanin. At the same time, it also has the function of diluting formed melanin, accelerating the decomposition and excretion of melanin, reducing skin pigmentation, and removing spots and freckles.

What are the application directions of arbutin?

It is the safest and most effective whitening raw material popular today, and it is also an ideal skin whitening and freckle removing active agent in the 21st century. Accelerates the speed of wound healing, and arbutin is also commonly found in some acne-removing and repairing products.

Alpha-Arbutin VS Beta-Arbutin

1. The price of α-arbutin is about 8 times that of β-arbutin.

2. The whitening effect of α-arbutin is more than 15 times that of β-arbutin.

3. α-Arbutin has stronger inhibitory effect on tyrosinase activity.

4. The stability of α-arbutin is better, α-arbutin will not decompose at a high temperature of 100°; β-arbutin will decompose a little over 60°.

5. α-Arbutin has no photosensitivity and can be used during the day.

6. α-Arbutin does not exist in nature and can only be obtained by fermentation.

7. β-Arbutin has been used in the market for a long time, so generally speaking, arbutin is β-arbutin, not α-arbutin.

At present, the two most commonly used arbutin in cosmetics are α-arbutin and β-arbutin. The price of α-arbutin is much higher than that of β-arbutin, mainly because β-arbutin Fruit glycosides are obtained by chemical synthesis, while α-arbutin can only be prepared by enzymatic synthesis (microbial fermentation).

In addition to the difference in technology, the biggest difference in physical properties between the two is the optical rotation: the optical rotation of α-arbutin is about +180 degrees, while that of β-arbutin is about -60 degrees. In addition, compared with β-arbutin, α-arbutin is more soluble in water and has high temperature resistance, good photostability, no cytotoxicity within a safe dose, and the effect of inhibiting melanin production is stronger than that of β-arbutin. 10-15 times, so advanced whitening cosmetics generally use α-arbutin.

Precautions:

1. Arbutin is easily decomposed in an acidic environment, pay attention to the control of the pH value of the system above 6.0;

2. Arbutin should be dissolved in a small amount of water at 45°C during use, and added at 45°C after the cream is completely emulsified;

3. An appropriate amount of antioxidants such as sodium bisulfite should be added to the formula system;

4. It can be effectively compatible with zwitterionic surfactants and anionic surfactants when formulating;

5. Adding natural vegetable oil containing oleic acid and linoleic acid can promote the synergistic effect of arbutin;

6. Azone, octadecyl dimethyl amine oxide, etc. can promote the absorption of arbutin;

7. Recommended dosage: 2～7%. Packing: 1kg aluminum foil bag; 25kg/cardboard drum; Storage and transportation: shading, sealing, and storing in a dry place

Preparation

1. Natural plant extraction method

This method mainly uses plant leaves of the genus Ursi as raw materials, and uses organic solvent extraction, extraction, column chromatography and other separation and purification methods to obtain arbutin extract. As early as 1930, it was reported that arbutin is contained in the leaves of rock cabbage. Subsequent studies have confirmed that arbutin is also found in the leaves of black rice tree, bilberry, bearberry and pear tree. glycosides.

Since the content of arbutin in plants is very low, the extraction process is relatively complex, and the purity of the extract is not high, so with the development of other preparation methods, the plant extraction method has gradually lost its competitive advantage.

2. Plant tissue culture method

The plant tissue culture method utilizes the glycosylation ability of plant cells to convert hydroquinone into arbutin. Compared with plant extraction methods, the efficiency of obtaining arbutin using plant tissue culture methods is much higher. When applying this method, selecting an efficient plant tissue culture medium and determining appropriate culture conditions are key.

The raw materials used in the plant tissue culture method are clean, the conversion rate is high, and the production is pollution-free. However, the production cycle is long, the separation and purification is complicated, and the industrial development is relatively immature. Further understanding the growth mechanism of plant cells, clarifying the key influencing factors of the synthesis process, shortening the production cycle, and improving yield are the key issues that need to be solved in the application of this method.

3. Enzyme synthesis method

The enzyme synthesis method mainly uses glycosyltransferase or glycosidase as a catalyst to catalyze glycosyl transfer and reverse hydrolysis reactions to synthesize glycosides, that is, arbutin is obtained from hydroquinone and glucose under the catalysis of glycosidase.

The enzyme synthesis method has a simple process, high synthesis efficiency, and very optimistic development prospects. With in-depth research on this method in recent years, more and more suitable zymogens have been discovered, and the synthesis rate of arbutin is also getting higher and higher. It is believed that this method will be one of the main research directions for the synthesis of arbutin in the future. one.

4. Chemical synthesis method

Generally, chemical synthesis of arbutin uses glucose and hydroquinone as raw materials. After the two are appropriately protected, they undergo a glycosidation reaction and then remove the protecting group. The chemical synthesis method has become the most important method for preparing arbutin due to its advantages of better synthetic product quality and lower production cost, and has achieved industrial production at home and abroad.

Safety

Because hydroquinone has the effect of inhibiting tyrosinase, it was used in early anti-freckle and whitening cosmetics to reduce skin pigmentation. Later studies found that hydroquinone has the risk of causing exogenous ochronosis and vitiligo, as well as the potential for sensitization. Risk, listed as a prohibited ingredient in cosmetics. Arbutin is also a tyrosinase inhibitor and a substitute for hydroquinone. Under conditions such as low pH value, high temperature, and ultraviolet irradiation, arbutin may be converted into hydroquinone under the action of skin microorganisms or glucosidase, resulting in potential risks of sensitization, genotoxicity, or carcinogenesis. Therefore, the safety research of arbutin has always attracted industry attention.

In February 2023, SCCS issued its final opinion on the safety of α-arbutin and β-arbutin in cosmetics (SCCS/1642/22), with the following conclusions:

1. The maximum safe concentration of α-arbutin in facial cream is 2%, and the maximum safe concentration in body lotion is 0.5%. It is also safe to use both at the same time.

2. The maximum safe concentration of β-arbutin in facial cream is 7%.

3. In products containing alpha-arbutin or beta-arbutin, the content of hydroquinone should be kept as low as possible and should not be higher than the unavoidable trace amounts in both arbutins. In the latest study submitted by the applicant, hydroquinone had a limit of quantitation (LOQ) of 3 ppm and a limit of detection (LOD) of 1 ppm.

4. The total exposure of alpha-arbutin (2% in face cream and 0.5% in body lotion) and beta-arbutin (7% in face cream) is considered safe.

Company introduction and certificates obtained

YTBIO mainly supplies Beta Arbutin powder, etc. The company was established in 2014 and has many years of experience in R&D and production. We are committed to the R&D, production and sales of raw materials for the health industry in the 21st century. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA etc. We always maintain the highest demands on product quality.

Our packaging

Our packing method is 1KG/Aluminium bags, 25kg/drum

For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin

Our team

Our team is professional, and our business team has undergone strict and professional product training. To ensure that our customers have a good cooperation experience and all questions during the cooperation process can be answered in a timely manner.

Factory

Payment method

The payment methods we support are: T/T, VISA, XTransfer, Master Card, Western Union, Alibaba Payment, e-Checking, Online Bank Payment

Shipping method

We support shipping by sea, air, DHL, FedEx, TNT, UPS, EMS, SF

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