Trifluoroacetyl tripeptide-2 is an active tripeptide derived from elastase inhibitor. It has excellent emulsifying, dispersing, antistatic, spreading, and wetting abilities, avoiding the damage of residual substances to the natural protective layer of the skin, and can long-term use.
Studies have shown that cellular senescence and progerin are closely linked. Progerin builds up in the body as we age, causing nuclear defects and DNA damage, resulting in a series of skin aging phenomena. Trifluoroacetyl tripeptide-2 can reduce the synthesis of progerin protein, improve skin laxity, sagging and wrinkles caused by it.
Skin aging is characterized by progressive changes in the regulation of cellular processes and miscommunication between cells and their immediate environment, the extracellular matrix (ECM). These dysfunctions may be caused by physiological and/or environmental events and are most notably characterized by increased activity of metalloproteinases (MMPs) and reduced synthesis of their endogenous inhibitors, tissue MMP inhibitors (TIMPs),1 –5 and decreased biosynthesis of major ECM proteins. As a result, the extracellular matrix is no longer renewed and the skin shows an aging effect.
Trifluoroacetyl tripeptide-2 is a polypeptide synthesized from 3 amino acids, which works by inhibiting the production of progerin, a protein that promotes cellular aging. Studies have found that trifluoroacetyl tripeptide-2 can restore cell activity to the level of young cells at the age of 20, and this ingredient can well increase skin elasticity, firmness and reduce skin sagging.
In their in-vivo (real-life) tests, they found that 2% Progeline cream lifted a sagging jawline by 10% in 56 days, and improved skin elasticity and thickness by about 20% in 28 days.
Trifluoroacetyl tripeptide-2 significantly increases syndecan-1 synthesis in human keratinocyte monolayers. This stimulatory effect of the tripeptide at concentrations of 0.0005 ppm and 0.005 ppm was approximately +19% and +56%, respectively (p < 0.05), and was comparable to that obtained with the well-known inducer of syndecan synthesis, TGF-β quite. 21 This suggests that TT2 has the potential to reverse the effects of aging. Taken together, these results demonstrate that the tested tripeptides exhibit activity in protecting the extracellular matrix, maintaining healthy interactions between cells and their surrounding matrix, and stimulating metabolic pathways in skin cells.
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