Introduction:

Hydroxytyrosol is a natural polyphenol compound with strong antioxidant activity. It mainly exists in the form of esters in the fruits, branches and leaves of olives.

【Other Names】3,4-Dihydroxyphenylethanol

【C A S No.】10597-60-1

【Source】Olive leaf, olive oil

【Analysis method】 HPLC

Hydroxytyrosol is a natural compound widely found in plants and animals, also known as lactitol or sorbitol. It is a simple sugar alcohol that has a sweet taste but does not cause an increase in blood sugar levels. Hydroxytyrosol is widely used in food, medicine, cosmetics and other fields and has a variety of health care effects. The chemical structure of hydroxytyrosol is similar to glucose and fructose, but its metabolic pathways are different from these two simple sugars. Hydroxytyrosol can generate hydroxytyrosol diphosphate and hydroxytyrosol triphosphate through phosphorylation and reduction in the body, and then participate in biochemical processes such as glycogen metabolism and gluconate pathway. In the food field, hydroxytyrosol is often used as a low-calorie, low-calorie alternative sugar additive. It can be added to beverages, candies, chocolates, pastries and other foods to achieve a sweet taste. Since hydroxytyrosol is not completely absorbed by the human body, it has a positive effect in controlling blood sugar levels in the large intestine and reducing obesity. It is fermented and decomposed by bacteria, so it can reduce the body's absorption and consumption of sugars. Hydroxytyrosol also has a variety of health care effects. In the medical field, it is used to treat diseases such as diabetes, hypertension, hyperlipidemia, and obesity. Hydroxytyrosol can lower blood sugar, blood lipids, blood pressure and other indicators, and reduce the risk of cardiovascular disease. At the same time, it can also promote the balance of intestinal flora, enhance immunity, and prevent dental caries. In the field of cosmetics, hydroxytyrosol is also widely used. It has moisturizing, antioxidant, antibacterial and other functions, and can be used as a moisturizer, antioxidant and preservative in cosmetics.

Hydroxytyrosol has anti-inflammatory effects, dilates blood vessels and antibacterial effects, can prevent atherosclerosis, and can reduce the incidence of certain cancers (such as breast, prostate, endometrium, digestive tract); because hydroxytyrosol has strong antioxidant activity and Reduces the incidence of cancer and therefore has great promise for medical use. Hydroxytyrosol is a tyrosol metabolite also found in olive oil that contains strong antioxidant properties.

1. Used in beauty products and health care products, it can effectively enhance skin elasticity and moisture, and has anti-wrinkle and anti-aging effects.

2. Helps the body's absorption of minerals. It does not require calcium supplementation. It is absorbed naturally, maintains bone density, reduces bone porosis, and at the same time improves the function of the endocrine system, promotes metabolism, promotes wound healing, eliminates free radicals in the body, and restores the function of the human body's organs. Healthy state, prevent brain failure, delay aging, and maintain youthful vitality.

3. It can prevent and treat lung cancer, breast cancer, uterine cancer, prostate cancer, etc., promote late-stage recovery of cancer and improve the effect of chemotherapy.

4. Prevent and treat various diseases caused by smoking.

5. It has miraculous effects on the prevention and treatment of arteriosclerosis, hypertension, heart disease, cerebral hemorrhage, etc., and is superior to similar drugs.

6. In addition, hydroxytyrosol can be used as a natural antibacterial, antiviral and fungicidal product for agricultural and pest control purposes.

Hydroxytyrosol is regarded as one of the most powerful antioxidants, and its market demand is increasing day by day. Its oxygen free radical absorption capacity is approximately 4,500,000μmolTE/100g: 10 times that of green tea, and more than 2 times that of CoQ10 and quercetin. Professor Liu Jiankang, director of the Institute of Mitochondrial Biomedicine of the Xi'an Jiaotong University Academy of Sciences, cooperated with the Swiss DSM nutritional products company to systematically study the effects of hydroxytyrosol, a polyphenol extract in olive oil, from the perspective of molecular biology. It shows that this substance promotes mitochondrial function by promoting mitochondrial synthesis. They found that olive oil extract hydroxytyrosol can effectively protect the oxidative damage and mitochondrial dysfunction of retinal pigment epithelial cells caused by acrolein, a toxic component of cigarettes. The main mechanism is that hydroxytyrosol can Induces a two-phase enzyme system with detoxification effect in cells. These results suggest that hydroxytyrosol may have a protective effect on smoking-induced retinal pigment epithelial cell degeneration, such as retinal maculopathy. The results also support that a diet rich in olive oil will be beneficial in the treatment of diseases related to mitochondrial dysfunction, such as diabetes and obesity.

market outlook:

, currently hydroxytyrosol is mainly isolated from olive fruits, leaves, residues and wastewater produced in the process of preparing olive oil. The purification of hydroxytyrosol mainly uses column chromatography separation methods, such as silica gel columns and ion exchange resins. Another method is to synthesize hydroxytyrosol through biosynthesis, which will be briefly introduced below.

Tyrosinase is the key enzyme that catalyzes the conversion of monophenolic hydroxyl groups into o-diphenolic hydroxyl groups. Studies have found that dispersing tyrosol in sodium phosphate buffer salt (pH=6.6), in the presence of mushroom tyrosinase and ascorbic acid, By injecting oxygen into the system, tyrosol can be completely converted into hydroxytyrosol. Ascorbic acid is added to reduce the over-oxidized diquinone compound into hydroxytyrosol. The use of bacteria to synthesize hydroxytyrosol has also been reported. Experimental findings: Serratia marcescens and Pseudomonas aeruginosa. These two bacteria can efficiently convert tyrosol into hydroxytyrosol. Later, microbial solid-phase coating technology was used to immobilize Pseudomonas aeruginosa on calcium alginate hydrogel. After immobilization, tyrosol can be Conversion to hydroxytyrosol at higher concentrations also enables the recovery and reuse of this biocatalyst without significant reduction in catalytic efficiency.

The use of biological methods to synthesize hydroxytyrosol has the advantages of safety, greenness and pollution-free. However, currently, both in terms of cost and large-scale production technology, its bioconversion to hydroxytyrosol can only be achieved at lower concentrations. ) are subject to certain restrictions. Looking for new efficient and specific enzymes or bacteria and the use of immobilized biocatalysts and other technologies to achieve the conversion of tyrosol to hydroxytyrosol at higher concentrations will be a promising application for the preparation of hydroxytyrosol through biological methods. research direction.

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