PQQ occurs naturally in a variety of foods, including plant-derived foods (such as potatoes, spinach, parsley, green peppers), fermented foods (such as fermented soybeans - natto, tofu, miso) and animal-derived foods (such as milk, egg). The content of free PQQ in food ranges from 1-30 ng/g, and the content in natto is as high as 61 ng/g. In human breast milk, PQQ has been detected in a concentration range of 140-180 ng/mL, as shown in the following table:
|
Food |
PQQ(ng/g) |
|
potato |
16.6±7.3 |
|
parsley |
34.2±11.6 |
|
green pepper |
28.2±13.7 |
|
Spinach |
21.9±6.2 |
|
green tea |
29.6±12.9 |
|
natto |
61.0±31.3 |
|
breast milk |
140-180* |
As a coenzyme of oxidoreductase, PQQ participates in electron transfer in the respiratory chain and has a variety of biological functions. This is why PQQ has attracted great attention in nutrition and pharmacology since its discovery in 1979. "nature" and The two authoritative magazines "Science" have also repeatedly reported on its miraculous effects.
On March 1, 2022, the national announcement officially listed pyrroloquinoline quinone disodium salt (PQQ) as a new food raw material. Pyrroloquinoline quinone disodium salt is made from 6-amino-5-methoxy-1H-indole-2-carboxylic acid ethyl ester and 2-oxoprenedioic acid dimethyl ester, and is coupled to form It is made by ring reaction, quinoline ring formation, oxidation reaction, ester hydrolysis reaction and refining. Pyrroloquinoline quinone disodium salt naturally occurs in a variety of foods such as milk, eggs, spinach, etc.
Pyrroloquinoline quinone disodium salt is managed as a "generally recognized substance (GRAS)" in the United States and can be used as a raw material in energy drinks, sports drinks, electrolyte drinks and other foods; in the European Union and Canada, it is used as a dietary supplement or natural health food .

Function:
1. Comprehensively improve human immune function
As an essential factor for human development, PQQ can stimulate the growth of human cells, especially activating human B cells and T cells to produce antibodies and improve the body's immune function. PQQ is the most powerful bioactive substance discovered by humans so far.
2.Prevent and treat liver damage
It can significantly reduce serum bilirubin and alanine aminotransferase levels, maintain normal liver function, regulate liver damage, and has excellent effects on liver diseases.
3. Reduce the damage of free radicals to the human body
PQQ is an oxidoreductase prosthetic group that participates in redox reactions in organisms. It can effectively remove free radicals in the body, reduce the damage of free radicals to the human body, protect body tissues, and reduce various diseases caused by body damage, such as heart disease. , cancer and various types of inflammation. Free radicals are the root of all diseases.
4. Regulate various neurological diseases
PQQ is a new type of water-soluble vitamin that can promote the synthesis of nerve factors in the human body and regulate various nervous system diseases.
5. Promote the absorption of amino acids
PQQ is the prosthetic group of quinone protease and participates in electron transfer in the respiratory chain. It can promote the absorption of amino acids through the action of glucose in the human body. Amino acids are the main raw materials for cell fluid and protein synthesis, and are important components of all biologically active substances.
6. Promote the synthesis of growth factors
Growth factors are human growth hormones that stimulate biological growth, stimulate human cell growth, and increase cell density. A trace amount of PQQ can improve the metabolic capacity and growth function of biological tissues.
7. Prevent Alzheimer's Disease
The special biological activity and physiological functions of PQQ are also reflected in its ability to repair nerve fibers, activate neurons, and activate dormant nerve cells, which can effectively prevent Alzheimer's disease and improve memory. Can effectively improve intelligence.
Judging from current research, PQQ has very good protective and improving effects on skin, liver, cardiovascular and cerebrovascular diseases:
● Help reduce oxidative damage and delay aging at the cellular level;
● Accelerate metabolism and enhance the liver's ability to metabolize alcohol and other substances;
● Prevent neurodegenerative diseases;
● Maintain neuron vitality and improve memory;
●Relieve stress and help sleep;
The efficacy of PQQ
1. Extensive nutritional functions
PQQ has a wide range of nutritional nourishing functions, which will be summarized from three aspects: microorganisms, plants and animals.
(1) PQQ promotes microbial growth
PQQ promotes the growth of microorganisms in two ways: (1) shortening the lag phase of the bacterial cells, functioning like a growth factor, accelerating the growth rate of the bacterial cells in a concentration-dependent manner, and increasing the cell yield; (2) only shortening the lag period of the bacterial cells period, does not accelerate the growth rate of bacterial cells.
(2) PQQ promotes plant growth
In 1988, it was first reported that PQQ could stimulate the germination of lily pollen. Subsequent studies found that PQQ could also stimulate the pollen germination of plants such as tea, musk lily, camellia oleifera, and tulips. They believe that the mode of PQQ stimulating pollen germination is roughly the same as that of stimulating microbial growth, that is, by shortening the growth lag period to stimulate plant growth.
Domestic scholars have found that PQQ can promote tobacco seed germination, increase lipase activity and seed respiration rate. PQQ can also promote plant growth by promoting the synthesis of auxin and cytokinin, promoting gene regulation at the molecular level, thereby increasing plant cell metabolism.
(3) PQQ affects the growth and reproduction of animals
For animals, PQQ is an essential nutritional factor even if it cannot be produced endogenously.
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