Formononetin, also known as Biochanin B, is an isoflavone phytoestrogen (Phytoestrogen), widely distributed in red clover, licorice, kudzu root, sandalwood, and Amorpha acacia Among other leguminous plants, red clover has the highest content. Formononetin has various physiological activities such as antibacterial, anti-tumor, lowering blood lipids, anti-arrhythmia, and improving estrogen levels. Formononetin can bind to and activate the estrogen receptor (ER) of mammals and humans, and has a two-way regulatory effect in the body, that is, it exerts anti-estrogenic activity when the estrogen level in the body is high, and It has estrogen-mimicking effects when estrogen levels in the body are low.
【English name】: Formononetin
【Appearance】:White crystal powder
【Specifications】: 98%HPLC( food grade )
【Grade】: Food and Medicine grade
【English alias】: 7-Hydroxy-3-(4-methoxyphenyl)chromone; 7-Hydroxy-4'-methoxyisoflavone; Dadein 4'-methyl ether
【CAS number】: 485-72-3
【EINECS number】: 207-623-9
【Molecular formula】: C16H12O4
【Molecular weight】: 268.26
【Molecular Structure:】：
【Density】: 1.329g/cm3
【Melting point】: 256-260℃
【Boiling point】: 479.4℃ at 760 mmHg
【Flash point】: 183.4℃
【Vapor Pressure】：8.17E-10mmHg at 25℃
【Solubility】：Easily soluble in methanol, ethyl acetate, diethyl ether, and dilute alkali solutions, but difficult to dissolve in water.
【Plant source】：The inflorescences and flowering branches and leaves of the leguminous plant Trifolium Pratense L, and the whole plant of Ononis spinosa.
【Part Used】:flower and leaf
【Storage Requirements】：Avoid contact with oxides. Store in a sealed and ventilated, dry place to avoid contact with other oxides.
【Function】:
1.Improving health, anti-spasm, known for healing properties
2.Treatment of skin diseases (such as eczema, burns, ulcers, psoriasis)
3.Treatment of respiratory discomfort (such as asthma, bronchitis, intermittent cough)
4.Prevention of prostate disease.
5.Estrogen-like effect,alleviate breast pain suffering.
6.Maintaining bone mineral density in postmenopausal women.
【Application】:
1.As raw material of drug for anti-cancer and anti-tumor, it is widely used in pharmaceutical field;
2.As estrogen and the added ingredients of drugs for lowering blood pressure, antispasmodic, it is widely used in health industry;
3.With the effect of improving skin and firming skin,it is widely added to all types of cosmetics.
What is formononetin used for?
Formononetin controls the development and progression of cancer through different mechanisms, such as the inhibition of angiogenesis, induction of apoptosis, cell cycle arrest, inhibition of inflammation, and activation of tumor suppressor genes.
What is the solubility of formononetin?
Formononetin is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, formononetin should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Formononetin has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMF:PBS (pH 7.2) using this method.
Formononetin extraction method:
Dry red clover (Trifolium pratense L.) was crushed into powder, then soaked in 5 volumes of 90% methanol for 24 hours, and then boiled and refluxed for 4 hours. Repeat the process two more times. After cooling, filter the extract.
COA:
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Product home page introduction 1
FORMONONETIN 98% (RED CLOVER EXTRACT) • ANTIOXIDANT • ANTI-INFLAMMATORY • HAIR GROWTH
Formononetin 98% (FORM) is an isoflavone from the group of phytoestrogens that exhibits a broad spectrum of physiological effects beneficial to health. Isoflavones are a group of phytoestrogens of relevant interest in nutrition, medicine, and cosmetics that promote potential health benefits. Formononetin is highly relevant due to its biological properties, such as antioxidant, and anti-inflammatory activities. Formononetin can be obtained from red clover, a plant from the "Fabaceae" family. The Fabaceae family exclusively produces it and is extracted from the roots of T. pratense. Another isoflavone present in red clover, biochanin A, has been demonstrated to reduce the production of dihydrotestosterone (DHT), which is a hormone associated with hair loss. Additionally, it has been shown to help modulate inflammation.
Antioxidant Effects
Formononetin has been shown to be a potent and effective natural antioxidant capable of protecting cells from most free radicals. Formononetin boasts the most potent antioxidant activity, demonstrated in its capacity to inhibit lipid peroxidation.
Anti-Inflammatory Effects
Studies have shown that Formononetin demonstrated an inhibitory effect on NF-kB activation which suggests the potential therapeutic effect that Formononetin may have in protecting against inflammation.
INCI Nomenclature: Trifolium Pratense L.
Appearance: White Fine Powder
Solubility: Insoluble in water
Suggested Use Levels: 0.5-10.0%
Storage: Protected from direct light and humidity at a temperature of 50°-77°F (10°-25°C)
Shelf life: 12 months, properly stored, in a sealed container.
Common Uses: Antioxidant, skin conditioning, skin protecting
This product should be added to a formulation at the recommended usage rate.
All products sold are cosmetic grade; External Use Only; Cosmetic & Personal Care Formulations Only.
Product home page introduction 2
Formononetin is a phytoestrogen and isoflavone originally found in legumes in the Fabaceae family. Formononetin exhibits anti-inflammatory, antioxidative, anticancer, antihypertensive, anti-parasitic, anti-osteoporotic, and pro-angiogenic activities. Formononetin decreases expression of COX-2, malondialdehyde, TNF-α, and IL-6 and increases activity of superoxide dismutase and glutathione peroxidase in animal models of traumatic brain injury. In prostate cancer cells, formononetin increases expression of Bax and suppresses expression of IGF-1R, inducing apoptosis and inhibiting proliferation. In spontaneously hypertensive rats, formononetin decreases systolic blood pressure, increases expression of eNOS, and decreases expression of 5-HT receptors and α1-adrenergic receptors. Additionally, formononetin inhibits attachment and motility of Giardia. This compound also induces mesenchymal stem cell differentiation, increases expression of VEGF and VEGFR2, and promotes bone fracture healing.
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