Description
Aloe-emodin is an anthraquinone compound with the chemical formula C15H10O5. It is mainly derived from the dried roots of the Polygonaceae plant Rheum palmatumL, Rheum tanguticum Maxim.ex Balf or Rheum officinale Baill. and rhizomes. Aloe-emodin is the active antibacterial component of rhubarb. Bacteria that are sensitive to it include Staphylococcus, Streptococcus and diphtheria, subtilis, anthrax, paratyphoid and dysentery, among which Staphylococcus and Streptococcus are the most sensitive. Aloe emodin also has the function of inhibiting the biosynthesis of DNA, RNA and protein in cancer cells.
Source
The rhizome of Rheum palmatum L., the rhizome of medicinal Rhubarb R. officinale Baill., the rhizome of Rumex patientia L., the leaves of R. dentatus L., the leguminous plant Lentil. The roots of Cassia mimosoides L., the seeds of C. tora L., the seeds of C. occidentalis L., the fruits of Rhamnus davurica Pall., the lily plants Aloe vera, Aloe vera aloe vera.
Physical properties:
Orange needle-like crystals (toluene), or earthy yellow crystalline powder. Melting point 223~224°, easy to sublimate. Soluble in acetaldehyde, benzene, hot ethanol, dilute ammonia, sodium carbonate and sodium hydroxide aqueous solution. Easily soluble in hot ethanol. It appears yellow in ether and benzene, and crimson in ammonia and sulfuric acid.
Preparation method: Aloe-emodin can be obtained by extracting the crude product from the low-temperature drying of aloe juice with ethyl acetate, and then purifying it through silica gel column chromatography (petroleum ether-ethyl acetate).
Specifications: >90%; >98%, thin layer identification has only one spot, which is a single component.
Storage: Store in a cool and dry place.
Function
Antibacterial activity
At a concentration of 1.5 to 25 mg/ml, aloe emodin has inhibitory effects on Staphylococcus aureus, Streptococcus aureus, Bacillus diphtheriae, Bacillus subtilis, anthrax, Bacillus paratyphoid, and Shigella dysenteriae, among which Staphylococcus and Streptococcus are the most sensitive and antibacterial. The effective concentration is 15-25ug/ml. The in vitro inhibitory concentrations for Staphylococcus aureus 209P, Escherichia coli, and Shigella flexneri are 7.5 mg/L and 600 mg/L respectively. Their antibacterial effects are bacteriostatic rather than bactericidal. One of its mechanisms of action is to inhibit mitochondrial respiratory chain electron transport.
Aloe-emodin has a strong inhibitory effect on the nucleic acid and protein synthesis of Staphylococcus aureus. Aloe-emodin has a strong inhibitory effect on common clinical anaerobic bacteria. Among them, it can inhibit the growth of 90% to 100% of common Bacillus fragilis strains, and its MIC is slightly higher than that of metronidazole. At a concentration of 8 μg/ml, 76% to 91% of anaerobic bacteria can be inhibited.
Immunosuppressive effects
Aloe-emodin can inhibit the production of biological antibodies, inhibit the ability of carbon particles to clear away, reduce the weight of immune organs, reduce the number of white blood cells, and reduce the function of peritoneal macrophages. In vitro, it has a significant inhibitory effect on the incorporation of [3H]-TDR and [3H]Urd into lymphocytes at a concentration of 100 μg/ml.
Purgative effect
Aloe-emodin has strong purgative activity. Intestinal bacteria metabolize aloe-emodin, rhein, and rhein-anthrone, and the latter has strong purgative effect. Clinically used as a laxative, it has the effects of increasing appetite and relieving large intestine. According to foreign medical reports, aloe glycoside is hydrolyzed into aloe-emodin under the action of parasitic bacteria in the human body. This aloe-emodin stimulates the peristalsis of the intestinal wall. At the same time, due to the change in osmotic pressure, it is conducive to the elimination of waste in the intestine, thereby achieving irritation. Laxative, this stimulating purgative effect has special effects on constipation and hemorrhoids. Especially for middle-aged and elderly constipation, the therapeutic effect is more obvious.
Other functions
It has the effect of making hair soft and shiny, relaxing and refreshing, and eliminating dandruff.
This product showed genotoxic effects in the mutagenicity assay of hamster fibroblasts.
Protects teak wood from termites.
1. Enhance immunity: It can achieve the effect of improving immune function, help relieve a weak physical condition, and also improve problems such as decreased immunity and weak resistance.
2. Anti-inflammatory: It can achieve the effect of controlling inflammation and infection in the body, alleviate various inflammatory lesions, and inhibit inflammatory reactions.
3. Sterilization: It can kill pathogenic bacteria in the body and also improve lesions caused by pathogenic bacteria invasion or infection.
4. Promote digestion: It can promote gastric acid secretion and help improve symptoms such as loss of appetite, indigestion, nausea and vomiting.
5. Protect the skin: It can avoid serious damage to the skin and help promote skin recovery and healing.
Effect
1. Physical weakness: It can enhance physical fitness and improve physical effects, and helps improve disease resistance.
2. Skin wounds: It can promote the healing of skin wounds as soon as possible, and can also protect the wounds and avoid infection.
3. Dermatitis: It can kill bacteria on the skin and improve dermatitis caused by bacterial infection.
4. Indigestion: It can promote digestion, help improve appetite, and relieve loss of appetite.
5. Constipation: It can promote gastrointestinal peristalsis and help improve dry stool and difficulty in defecation.
Try to avoid taking it for a long time or in large doses, as it may increase the burden on the liver and kidneys and cause harm to your health.
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