What is Calcium glycerophosphate
Calcium glycerophosphate is a white or slightly yellow crystalline powder, odorless, almost odorless, and slightly bitter. Slightly hygroscopic in the air. It loses crystal water at 130℃ to form anhydrous substance and decomposes above 170℃. Each g is dissolved in about 50ml of 25℃ water. It is more soluble in water when the temperature is lower, and the aqueous solution is alkaline. Insoluble in ethanol, soluble in glycerol. Citric acid or lactic acid can improve its solubility in water, but it is easy to decompose when heated.
The function of Calcium glycerophosphate
In medicine, it is used to promote the calcification and formation of bones and teeth. Food nutritional supplements, food calcium fortifiers, stabilizers. Toothpaste grade glycerol calcium phosphate is used as a toothpaste additive in the toothpaste industry due to its good clarity, high solubility, and fast dissolution speed. Calcium glycerophosphate has antibacterial and anti-caries effects. It can increase the calcium and phosphorus content in tooth enamel, inhibit the demineralization of tooth enamel, and improve the remineralization of tooth enamel. It can change the acidity and alkalinity of tooth enamel surface and enhance its acid resistance. The pH of glycerol calcium phosphate used as a toothpaste additive is 1.7ml/g at a certain concentration. At the same time, in order not to affect the quality of the toothpaste, the clarity of the calcium phosphate needs to be at least slightly turbid. The method of neutralizing calcium hydroxide and glycerol phosphate is used, and through ethanol extraction, the calcium glycerophosphate meets the requirement of 1.7ml/g, the calcium glycerophosphate content is 80%, and the clarity reaches the clear toothpaste grade calcium glycerophosphate.
The role of calcium glycerophosphate in toothpaste is mainly reflected in the following aspects: ① Control of plaque. ② Protective effect on dentin. ③Influence on the ecological balance of oral flora. In addition, calcium glycerophosphate can improve the absorption of fluoride. Adding 0.1% to 0.13% calcium glycerophosphate to toothpaste containing SMFP can greatly increase the absorption rate of fluoride by enamel and strengthen the fluorination effect of enamel against demineralization.
Calcium glycerophosphate is an ideal toothpaste additive for preventing dental caries and treating gingivitis and periodontal disease. Due to its good protective effect in toothpaste, calcium glycerophosphate has been favored by the majority of toothpaste manufacturers. Abroad, such as Unilever, etc., all produce glycerol calcium phosphate toothpaste. Newly emerging national brands in China, such as Naisi, Oqili, etc., are optimistic about the market situation of high value-added glycerol calcium phosphate toothpaste. Currently, there are small-scale glycerol calcium phosphate toothpaste manufacturers. Production of calcium phosphate toothpaste. According to research, markets such as the United States, Japan, Europe, and Asia-Pacific now pay more attention to high-tech, high-additional toothpaste products, and are more concerned about the active ingredients in toothpaste. All these indicate that the market for glycerol calcium phosphate toothpaste has broad room for growth. In addition, calcium glycerophosphate can also be used in mouthwash.
Synthesis of calcium glycerophosphate
At present, the main methods for preparing glycerol calcium phosphate include phosphoric acid method, phosphate salt method, phosphorus oxychloride method, oil dripping method, etc. The processes of these methods are relatively complex, and the purification process of the target product calcium glycerophosphate is cumbersome and difficult to control. Calcium glycerophosphate is obtained by neutralizing calcium hydroxide and glycerophosphate through ethanol extraction to avoid the purification process of calcium glycerophosphate.
Content analysis of calcium glycerophosphate
Accurately weigh about 2g of the sample that has been dried at 150°C for 4 hours, and dissolve it in 100ml of water and 5ml of dilute hydrochloric acid test solution. Transfer this solution into a 250ml volumetric flask, bring it up to volume with water and shake well. Pipette 50.0ml of this solution into a suitable container and add 50ml of water. Under stirring (preferably with a magnetic stirrer), add about 30ml of 0.05mol/LEDTA disodium dropwise from the burette, then add 15ml of sodium hydroxide test solution and 300mg of hydroxynaphthol blue indicator, and then continue to dropwise add it to the blue end point. . Each ml of 0.05 mol/L disodium EDTA is equivalent to 10.51 mg of calcium glycerophosphate (C3H7CaO6P).
Application and prospects of calcium glycerophosphate
Calcium glycerophosphate is widely used in medicine, food, toothpaste and other industries. It can be used as a calcium supplement in food; in medicine, it plays the biological and physiological functions of calcium, has the function of improving tissue cells and forming bone tissue, and at the same time plays the role of calcium glycerophosphate metabolism, and has the function of supplementing calcium. The role of brain vitality. As early as 1960, calcium glycerophosphate was found to have antibacterial and anti-caries effects. Through research, it has been found that it can increase the calcium and phosphorus content in tooth enamel, inhibit the demineralization of tooth enamel, and improve the remineralization of tooth enamel. Calcium glycerophosphate can change the acidity and alkalinity of the tooth enamel surface and enhance its acid resistance. The advantages of calcium glycerophosphate are self-evident, but currently it is not widely used in my country’s oral care products industry. Calcium glycerophosphate is an excellent additive for oral products, especially suitable for calcium-supplementing toothpaste and chewing gum. It is also an anti-caries agent. An ideal raw material for additives, it can be used in children's toothpaste to promote tooth growth and calcium strengthening. Through the formulation experiments of various products, the addition of calcium glycerol phosphate, paying attention to the characteristics of calcium glycerol phosphate, has no obvious difference in the stability and other quality indicators of most oral care products compared with those without addition, and can give full play to the properties of calcium glycerol phosphate. Calcium has the ability to prevent caries, acid and remineralize teeth, so it should play a greater role in this field.
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