1.INTRODUCTION:
White or yellowish crystalline powder, odorless, almost odorless, slightly bitter. It is slightly hygroscopic in the air. At 130°C, it loses crystal water to form anhydrous matter, and decomposes above 170°C. Each g is soluble in about 50ml of 25°C water. It is more soluble in water when the temperature is lower, and the aqueous solution is alkaline. Insoluble in ethanol, soluble in glycerin. Citric acid or lactic acid can increase its solubility in water, but it is easy to decompose when heated. Commonly used in food calcium fortifiers, used in bread, flour, noodles, soybean milk, etc. The dosage is below 1%.
CAS number: 27214-00-2
Molecular formula: C3H7CaO6P
Molecular weight: 210.14
EINECS Number: 248-328-5
Structural formula:
Melting point: > 170°C
Density: 1.82-1.855[at 20℃]
Vapor pressure: 0Pa at 25℃
Storage conditions: Inert atmosphere, Room Temperature
Solubility: sparingly soluble in water, practically insoluble in ethanol (96 per cent).
Form: white to almost white powder to crystal
Customs code: 2919900090
2.CHEMICAL PROPERTIES:
Calcium glycerophosphate is a white crystalline powder. Odorless, almost odorless, slightly bitter, hygroscopic. It loses crystal water at 130°C and forms nothing, and decomposes above 170°C. 2Chemicalbook 5 ℃ per gram dissolved in about 50mL of water. It is more soluble in water when the temperature is lower, and the aqueous solution is alkaline. Citric acid or lactic acid can increase its solubility in water. Almost insoluble in boiling water. Insoluble in ethanol.
3.APPLICATION:
Calcium glycerophosphate is widely used in medicine, food, toothpaste and other industries. It can play the role of calcium supplement in food; in medicine, it plays the biological and physiological role of calcium, has the function of improving tissue cells and constituting bone tissue, and at the same time plays the role of calcium glycerophosphate metabolism. It has the function of supplementing the vitality of the brain.
4.TOOTHPASTE ADDITIVES:
As early as 1960, it was found that calcium glycerophosphate has the effect of antibacterial and anti-caries. Through research, it is found that it can increase the calcium and phosphorus content in tooth enamel, inhibit the demineralization of tooth enamel, and improve the remineralization of tooth enamel. Calcium glycerophosphate can change the acidity and alkalinity of the surface of tooth enamel and enhance its anti-acid ability. The advantages of calcium glycerophosphate are self-evident, but currently there are not many applications in the oral care products industry in my country. Calcium glycerophosphate is an excellent oral product additive, especially suitable for calcium-supplementing toothpaste and chewing gum. is also an anti-aging product. An ideal raw material for caries additives, it can be used in children's toothpaste to promote tooth growth and calcium fortification. The role of calcium glycerophosphate in toothpaste is mainly manifested in the following aspects:
① Controlling effect on plaque.
②Protective effect on dentin.
③Effect on the ecological balance of oral flora. In addition, calcium glycerophosphate can improve the absorption of fluoride. Adding 0.1% to 0.13% calcium glycerophosphate to toothpaste containing SMFP can greatly increase the absorption rate of fluoride by enamel and strengthen the fluoride effect of enamel against demineralization.
5.PREPARATION:
At present, the methods for preparing calcium glycerophosphate mainly include phosphoric acid method, phosphorus salt method, phosphorus oxychloride method, oil residue method, etc. These method processes are all more complicated, and the purification process of target product calcium glycerophosphate is more loaded down with trivial details, is difficult to control. Calcium hydroxide and glycerophosphate are neutralized to obtain calcium glycerophosphate through ethanol extraction, which avoids the purification process of calcium glycerophosphate. The reaction equation is as follows:
6.PRODUCTION METHOD:
Add metaphosphoric acid or sodium dihydrogen phosphate to glycerol, heat to obtain glycerol phosphoric acid, and then add lime milk to neutralize it. It is obtained by neutralizing glycerophosphoric acid with calcium hydroxide or calcium carbonate.
7.CONTENT ANALYSIS:
Accurately weigh about 2g of the sample that has been pre-dried at 150°C for 4 hours, and dissolve it in 100ml of water and 5ml of dilute hydrochloric acid test solution (TS-117). Transfer this solution into a 250ml volumetric flask, dilute to volume with water and shake well. Draw 50.0ml of this solution into a suitable container, and add 50ml of water. Under stirring (preferably using a magnetic stirrer), dropwise add about 30ml of 0.05mol/LEDTA disodium from the burette, then add 15ml of sodium hydroxide test solution (TS-224) and 300mg of hydroxynaphthol blue indicator, and continue Add dropwise to the blue end point. Every Ml0.05mol/L disodium EDTA is equivalent to 10.51mg of calcium glycerophosphate (C3H7CaO6P).
8.IDENTIFY
1) Take about 0.1g of this product, dissolve in 10ml of water and 10ml of dilute nitric acid, add 5ml of ammonium molybdate test solution, boil, and precipitate occurs.
2) Take about 0.1g of this product, add 0.1g of potassium bisulfate, mix, put it in a test tube, and the irritating odor of acrolein will occur.
3) Flame reaction of this product to display calcium (general rule 0301)
Use limit:
GB 14880-94: 1.6-3.2 for beverages; 1.6-3.2 for cereals and their products; 3-6 for infant food (mg/kg, all calculated as calcium).
use
Nutritional supplements; food calcium fortifiers; stabilizers. Used in baby food, bread, baking powder, wheat flour and noodles, etc. The amount added is less than 1% (calculated as Ca).
examine
pH
Take 1.0g of this product, dissolve it in 100ml of water, add 2 drops of phenolphthalein solution, titrate with sodium hydroxide titration solution (0.1mol/L) or hydrochloric acid titration solution (0.1mol/L), consume sodium oxide titration solution (0.1mol/L) L) or hydrochloric acid titration solution (0.1mol/L) shall not exceed 1.7ml.
Clarity and Color
Take 1.0 g of this product, dissolve it in 100ml of water, and check according to the law (general rule 0901 and general rule 0902), the solution should be clear and colorless, if it is turbid, it should not be thicker than No. 3 turbidity standard solution (general rule 0902 first method) .
chloride
Take 0.25g of this product, check according to the law (General Rule 0801), and compare it with a control solution made of 5.0ml of standard sodium chloride solution. Must not be greater than (0.02%).
Sulfate
Take 0.25g of this product, check according to the law (general rule 0802), and compare it with the control solution made of 5.0ml of standard potassium sulfate solution, the content should not be greater than 0.2%.
phosphoric acid
Take 1.0g of this product, put it in a 25ml Nessler colorimetric tube, add 10ml of dilute nitric acid to dissolve, add 10ml of ammonium molybdate test solution, shake well, and let it stand for 10 minutes. Potassium dihydrogen 0.192g, put in a 100ml measuring cylinder, add water to dissolve and release to the mark, shake well, accurately measure 3ml, put it in another 100ml measuring cylinder, add dilute nitric acid to the mark, shake well, and compare with the control solution made of 10ml , shall not be greater than 0.04%.
citrate
Put 5g of this product in a beaker, add 20ml of fresh cold water, dissolve and filter, add 0.15ml of sulfuric acid to the filtrate, shake, filter, add 5ml of mercury sulfate test solution to the filtrate, add to boiling, and then add potassium permanganate Add 0.5ml of the solution to boiling again, and there should be no precipitation.
Loss on drying
Take this product and dry it at 150°C for 4 hours, the weight loss shall not exceed 12.0% (general rule 0831).
iron salt
Take 1.0g of this product, dissolve it with 2ml of acid and 23ml of water, and check according to the law (General Rule 0807). Compared with the control solution made of 2.0ml of standard iron solution, the content should not be greater than 0.002%.
heavy metal
Take 1.0 g of this product, add 2 ml of acetate buffer solution (pH 3.5) and water to make 25 ml, check according to the law (general rule 0821 first method), heavy metals should not exceed 20 parts per million.
Arsenic salt
Take 0.67 g of this product, add 23 ml of water and 5 ml of acid, after dissolving, check according to the law (the first method of General Rule 0822), and it should meet the regulations (0.0003%). the
Assay
Take 0.2 g of this product, weigh it accurately, add 300ml of water and shake to dissolve, add 6.0ml of 10mol/L sodium oxide solution and 15 mg of calcium carboxylic acid indicator, and fix it with disodium diaminetetraacetic acid (0.05mol/L) until the solution turns purple. Every 1ml of disodium diaminetetraacetic acid titration solution (0.05mol/L) corresponds to 2.004mg of Ca.
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