Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of oleoylethanolamide in China. With abundant experience, we warmly welcome you to wholesale bulk oleoylethanolamide for sale here from our factory. Quality products and reasonable price are available.
What are Oleoylethanolamide?
Oleoylethanolamide (OEA), also known as oleoylethanolamine, is a member of the endogenous cannabinoids. It is a secondary amide compound composed of lipophilic oleic acid and hydrophilic ethanolamine.
OEA is also a naturally occurring lipid molecule in other animal and plant tissues. It is widely found in animal and plant tissues such as cocoa powder, soybeans and nuts, but its content is extremely low. Only when the external environment changes or food is stimulated, the body's cell tissues will produce more of this substance.
Application
3.26 g of oleoylmonoethanolamine are suspended in 20 ml of SOCl2 at 0 ° C and under a nitrogen atmosphere. The mixture is stirred at 0 ° C for 30 minutes and then at ambient temperature for 5 hours. The solution thus obtained is evaporated to dryness under reduced pressure. The residue is used without further purification. It is suspended in 20 ml of anhydrous toluene and 1.3 g of potassium tert-butoxide are added. The mixture is heated at 40 ° C for 2 hours and then cooled at 4 ° C. The solution is extracted 3 times with 6 ml of water and the extract is worked up. The organic phase is evaporated to dryness under reduced pressure and the brown residue is purified by distillation under a high vacuum of about 0.5 mm Hg. The fraction 2-(8-heptadecenyl)-2-oxazoline distilling at about 180 ° C is collected and stored in an inert atmosphere (yield: about 88%).
Properties
At room temperature, OEA is a white solid with a melting point of about 50°C. It is easily soluble in alcohol solvents such as methanol and ethanol, relatively soluble in non-polar solvents such as n-hexane and ether, and insoluble in water.
OEA is an amphiphilic molecule, and its traditional use is as a surfactant and detergent in the chemical industry. However, further studies have found that OEA can be used as a lipid signaling molecule in the gut-brain axis, and it exhibits a series of biological activities in the body, including: controlling appetite, improving lipid metabolism, strengthening memory and cognition. Among them, the functions of OEA in controlling appetite and improving lipid metabolism are the most concerned.
1. Controlling appetite and losing weight
OEA is an important food intake inhibitor. Its main function is to help slow down obesity. Intraperitoneal injection of OEA can effectively reduce food intake and weight gain in rats. Oral administration of OEA can also have a similar effect, but intraventricular injection of OEA does not affect rats' eating. The weight loss effect of OEA is mainly that it can induce satiety, thereby controlling excessive food intake. Adding a certain concentration of OEA to the feed of normal or obese mice can reduce the appetite of mice and reduce their weight.
OEA can not only inhibit intestinal absorption of fat, but also accelerate the β-oxidation of fatty acids by promoting the hydrolysis of triglycerides in peripheral tissues (liver and fat), ultimately reducing fat accumulation and achieving weight control.
2. Lowering blood lipids and preventing atherosclerosis
Peroxisome proliferator-activated receptor-α (PPAR-α) is a type of receptor in the body that is closely related to metabolic functions. PPAR-α binds to peroxisome proliferator response elements and participates in lipid metabolism transport, immune regulation, anti-inflammatory, anti-proliferation and other related processes, thereby playing a role in regulating blood lipids and preventing atherosclerosis.
OEA is an endogenous cannabinoid analogue that is produced when the body tissue is stimulated. Studies have shown that OEA activates PPAR-M, reduces the release of endothelin-1, inhibits vasoconstriction and smooth muscle cell proliferation, promotes vasodilation, and at the same time increases the synthesis of endothelial nitric oxide synthase, induces the production of more nitric oxide, and then reduces the generation of vascular cell adhesion molecules, achieving anti-inflammatory effects, and playing a role in lowering blood lipids and preventing atherosclerosis.
Company Introduction
Founded in 2014, YTBIO mainly supplies food additives such as Oleoylethanolamide, herbal extracts, functional cosmetic raw materials, organic products, etc. All of our products are produced by ourselves. At present, our certificates include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA, etc. All our products have been tested and we support third-party testing. We provide a variety of products, for any detailed information about the products, please click Sales@sxytbio.Com Contact us, we will have professional sales staff to give you detailed answers
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