L-Ornithine L-Aspartate Salt

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of l-ornithine l-aspartate salt in China. With abundant experience, we warmly welcome you to wholesale bulk l-ornithine l-aspartate salt for sale here from our factory. Quality products and reasonable price are available.

L-Ornithine L-Aspartate Salt was developed in Germany in the 1960s and was first used in the clinic to treat hangovers and hepatic encephalopathy. With the accumulation of clinical application experience, ornithine aspartate has been more widely used in the treatment of liver diseases, and has achieved definite therapeutic effects on hepatic encephalopathy, drug-induced liver damage, fatty liver, chronic hepatitis and other diseases, and has been widely recognized by clinical physicians.

Physical and chemical properties

Ornithine aspartate is a stable dipeptide compound prepared by chemical synthesis of L-ornithine and L-aspartic acid. It is very soluble in water and almost insoluble in methanol or ethanol. Once this product enters the human body, it is decomposed into aspartic acid and ornithine, which can directly participate in liver cell metabolism and activate two key enzymes in the liver's detoxification function. Therefore, it can help remove free radicals that are harmful to the human body, enhance the liver's detoxification function, quickly reduce excessive blood ammonia, and promote the repair and regeneration of liver cells themselves, thereby effectively improving liver function and restoring the body's energy balance.

1. Hepatic encephalopathy (HE)
In the 2014 American Association of Liver Diseases and European Association of Liver Diseases practice guidelines for hepatic encephalopathy due to chronic hepatitis, ornithine aspartate is recommended for the treatment of hepatic encephalopathy. In a recent meta-analysis on ornithine aspartate in the treatment of cirrhosis and hepatic encephalopathy, 8 randomized controlled trials with a total of 646 patients were included. The results showed that ornithine aspartate can significantly improve the treatment of liver cirrhosis and hepatic encephalopathy. It can improve the clinical symptoms of patients with overt hepatic encephalopathy and mild hepatic encephalopathy (MHE), and can significantly reduce the blood ammonia levels of patients.

In domestic research, ornithine aspartate was used to treat MHE, and the clinical efficacy and safety were observed. The results showed that after ornithine aspartate treatment, NCT A, B, DST, line tracking test, blood ammonia, ALT, AST, prothrombin time, peripheral blood red blood cells, and white blood cells were significantly better than before treatment in all patients. In another study, Ornithine Aspartate Granules were used to treat MHE and the patients' quality of life was compared. It was found that Ornithine Aspartate could effectively reduce blood ammonia and improve intelligence test indicators compared with the control group. There was a significant difference in patient quality of life between the two groups.

2. Fatty liver disease
Fatty liver disease is divided into alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) based on whether the patient has a history of excessive drinking. 200 patients (140 cases with alcoholic fatty liver disease and 60 cases with alcoholic hepatitis) were randomly divided into two groups. The treatment group was treated with ornithine aspartate, and the control group was treated with Ganan injection. The results showed that at the end of treatment, the biochemical indicators of the treatment group improved significantly (P<0.05), and the ALT and AST levels were lower than those of the control group (P<0.05).

In a domestic multi-center parallel controlled clinical study, 87 patients with non-alcoholic steatohepatitis (NASH) were included in the research group. The patients were treated with aspartate-ornithine granules for 12 weeks. The results showed that after treatment, the patients not only suffered from liver and spleen damage The CT ratio increased compared with before treatment, and the serum ALT, AST, GGT and TG levels also improved to varying degrees, and as the drug dose increased, the drug efficacy was further enhanced, suggesting that aspartate-ornithine granules It has a certain therapeutic effect on liver steatosis and liver inflammation, and shows a better effect on improving liver steatosis in patients with moderate to severe fatty liver (liver-spleen CT ratio <0.7).

3. Drug-induced liver damage

In a domestic study, 46 patients with drug-induced liver damage were randomly divided into two groups. The results showed that ornithine aspartate can significantly reduce the levels of ALT, AST, TBil, GGT and ALP in patients with drug-induced liver damage. level. After 1 to 6 weeks of treatment, the patient's clinical symptoms were significantly relieved, with only one case experiencing adverse reactions of transient nausea and vomiting. All enzymatic indicators and bilirubin indicators were significantly lower than those in the control group.

4. Chronic liver disease

Improvement of GGT: 200 patients with chronic liver disease were divided into three groups according to the serum GGT results after 12 weeks of treatment. Different therapeutic agents were used, and the patients all maintained the initial dose of treatment until 24 weeks. Liver function was detected, and the normal rate of serum GGT in each group was compared and analyzed. The results showed that for patients whose serum GGT did not return to normal in a short period of time, the original dose was used for consolidation treatment for 24 weeks. Ornithine aspartate was more effective than compound glycyrrhizin. Ornithine aspartate is suitable for patients to take for a long period of treatment. It is not easy to rebound after stopping the drug and has high safety.

L-Ornithine-L-Aspartate is a drug for the treatment of hepatic encephalopathy and other chronic liver diseases. It is mainly used for the treatment of elevated blood ammonia caused by acute and chronic liver diseases (such as various types of hepatitis, cirrhosis, fatty liver, and post-hepatitis syndrome) and the treatment of hepatic encephalopathy, such as concomitant or secondary to impaired liver detoxification function or acute hepatic encephalopathy. It is especially suitable for the treatment of confusion in the early stage of hepatic coma or during the hepatic coma period.

YTBIO mainly supplies L-Ornithine L-Aspartate Salt etc. The company was established in 2014 and has many years of R&D and production experience. We are committed to the research and development, production and sales of raw materials for the 21st century health industry. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA,etc. We always maintain the highest requirements for product quality.

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