Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of pure papain powder in China. With abundant experience, we warmly welcome you to wholesale bulk pure papain powder for sale here from our factory. Quality products and reasonable price are available.
What is papain powder?
Pure Papain powder is a proteolytic enzyme. Papain is a low-specificity proteolytic enzyme contained in Carieapaya. It is widely present in the roots, stems, leaves and fruits of Carieapaya, and is most abundant in immature milk. The active center of papain contains cysteine and is a thiol protease. It has the characteristics of high enzyme activity, good thermal stability, natural health and safety, etc., so it is widely used in food, medicine, feed, daily chemicals, leather and textile industries. application.
Papain is a sulfide-containing (-SH) endopeptidase with protease and esterase activities, broad specificity, and strong hydrolysis ability for animal and plant proteins, polypeptides, esters, amides, etc. , at the same time, it also has a synthetic function and can synthesize protein hydrolyzate into protein-like protein. Soluble in water and glycerin, the aqueous solution is colorless or light yellow, sometimes milky white; almost insoluble in organic solvents such as ethanol, chloroform and ether. The most suitable pH value is 5.7 (generally 3 to 9.5 is acceptable), and it is also effective in neutral or acidic conditions. The isoelectric point is 18.75; the most suitable temperature is 55 to 60°C (generally 10 to 85°C is acceptable), heat resistance It is strong and will not be completely deactivated at 90°C; it is inhibited by oxidants and activated by reducing substances. Enzyme that is dried without clarification is crude enzyme.
Papain is a proteolytic enzyme with a molecular weight of 23,406 and consists of a single peptide chain containing 212 amino acid residues. There are at least three amino acid residues present in the active center of the enzyme. They are Cys25, His159 and Asp158. When Cys25 is oxidized by oxidants or combined with metal ions, the activity of the enzyme is inhibited, while the reducing agent cysteine (or Sulfites) or EDTA can restore enzyme activity. The other six cysteine residues formed three pairs of disulfide bonds, and none of them were in the active site. Pure papain products can contain: (1) papain, molecular weight 21,000, accounting for approximately 10% of soluble protein; (2) chymotrypsin, molecular weight 26,000, accounting for approximately 45% of soluble protein; (3) lysozyme, molecular weight 25,000, accounting for about 20% of soluble protein; and different enzymes such as cellulase.
chemical properties
Papain is a protease that can decompose proteins in acidic, neutral, and alkaline environments. Its appearance is white to light yellow powder, slightly hygroscopic; papain is soluble in water and glycerin, and the aqueous solution is colorless or light yellow, sometimes milky white; it is almost insoluble in organic solvents such as ethanol, chloroform, and ether. Papain is a sulfhydryl (-SH)-containing endopeptidase with protease and esterase activities, broad specificity, and strong hydrolysis ability for animal and plant proteins, polypeptides, esters, amides, etc. But it can hardly break down peptone.
The most suitable pH value of papain is 6 to 7 (generally 3 to 9.5 is acceptable), and it also works in neutral or acidic conditions. The isoelectric point (pI) is 8.75; the most suitable temperature of papain is 55 to 65°C ( Generally, it can be anywhere from 10 to 85℃), it has strong heat resistance and will not be completely deactivated at 90℃; it is inhibited by oxidants and activated by reducing substances.
Catalytic mechanism
The mechanism of papain cleavage of peptide bonds includes: deprotonation of Cys-25 under the action of His-159, and Asn-158 can help arrange the imidazole ring of His-159 so that deprotonation can occur; then Cys- 25 nucleophilically attacks the carbonyl carbon on the peptide backbone and covalently connects it to form an acyl-enzyme intermediate; then the enzyme interacts with a water molecule to deacylate and release the carbonyl end of the peptide chain.
What are the benefits?
1. Help digestion
Papain supplements are used to improve gastrointestinal dysfunction and common digestive problems such as bloating and constipation.
Like other proteases, research shows that papain helps the body break down protein-based foods, such as animal meat. But this papaya enzyme does not require the presence of acid to do its job.
This means that even people with low stomach acid, who often have difficulty breaking down and digesting certain types of meat, may benefit from papain supplements.
2. Reduce inflammation
Papain has been shown to reduce inflammation in people with asthma, arthritis, and other inflammatory conditions.
Research published in 2013 in the journal Nutritional Reviews showed that proteolytic enzymes including papain and trypsin can break down pathogenic immune complexes and even prevent them from forming in the first place.
This means papain may be able to prevent inflammation, thereby enhancing lymphatic drainage and modulating the immune system.
A review of the literature published in the Journal of Immunotoxicology found that both in vitro and in vivo studies indicate that papaya extract and papaya-related phytochemicals have anti-inflammatory and immunomodulatory properties, but more clinical studies are needed to fully understand these effects.
3. Relieve pain
Several studies have shown that papain can relieve pain in many areas, including muscle pain from strenuous exercise, sore throats, and shingles-related pain.
A study published in the Journal of Clinical Pediatric Dentistry found that a papain-based gel called Papacarie was effective in removing infected tissue in patients with cavities or cavities.
Studies show that the gel helps reduce pain and inflammation without the need for anesthesia or drilling during tooth extraction.
A study published in the Journal of Sports Science suggests that taking a protease supplement containing papain may help relieve muscle pain caused by running.
Participants took protease tablets containing 50 mg of papain in addition to other enzymes such as bromelain, trypsin, amylase, and lipase. Runners who took two pills four times a day for four days showed better recovery and less muscle soreness than the placebo group.
Additionally, a 1995 German study evaluated the effectiveness of an enzyme combination containing papain in treating shingles, or shingles.
The researchers found that the enzyme preparation showed the same efficacy as acyclovir, an antiviral drug used to treat herpes virus infections. The enzyme combination was able to reduce pain associated with shingles after 14 days of treatment.
4. May have anti-tumor effects
An animal study conducted in Italy found that when cancerous mice were immunized with papain, their average survival time increased compared with unimmunized controls.
After mice were immunized with papain, the growth rate, invasion and metastasis of cancerous tumors were inhibited.
5. Fight infection
Because of its antiviral and antifungal properties, papain has been used in non-traditional wound care.
Papain appears to fight infection by destroying the protein layer that protects fungi and viruses from attack. This reduces their ability to reproduce, spread and cause infection.
6. Support wound healing
Topical papain products are commonly used for their wound-healing effects, although the FDA warns consumers of the potential for allergic reactions when the enzyme is applied topically.
There is preliminary research supporting the ability of papain to support wound healing. A 2010 animal study in Malaysia found that papain-based wound cleansers helped reduce wounds, promote collagen deposition and had antibacterial properties.
7. Lose weight
Papain is a natural plant protease that can promote digestion and absorption in the human intestine. While ensuring a normal diet without excessive intake, papain can quickly help people decompose residues in the intestine. Papain can not only It decomposes proteins, sugars, and even fat. By decomposing fat, you can remove fat, shrink mast cells, promote metabolism, and expel excess fat from the body in a timely manner, thereby achieving the goal of losing weight!
8. Antioxidant
Papain inhibits the oxidation reaction of free radicals. Its mechanism of action can be to directly act on free radicals, or to consume substances that easily generate free radicals to prevent further reactions. Medical research has proven that the human body's antioxidant system is a system with complete and complex functions comparable to the immune system. The stronger the body's antioxidant capacity, the healthier it is. The external manifestation of the body is good skin condition. Look young and full of energy.
9. Improve immunity
After papain acts on the human body, it will stimulate the liver to secrete metabolic enzymes. Various residual drugs and living garbage in our body will be cleaned up by metabolic enzymes. Studies have found that the metabolic process is usually completed by a series of enzymatic reactions, and the result is that the external The source material undergoes a chemical reaction to deactivate it and excrete it from the body, while improving the body's immunity.
Application direction
Papain is widely used in medical treatment, food, beverages, chemical reagents, feed, textile cosmetics, etc.
Papain is mainly found in the milk of immature papaya fruits. It can effectively break down common proteins such as gelatin, casein, gluten, elastin, globulin and myofibrillar protein. It is widely used in meat tenderization and beer clarification. , gelatin manufacturing, silkworm cocoon degumming, leather hair removal and other industries, and has wider uses in medical and health aspects.
Medications containing papain have anti-inflammatory, choleretic, analgesic and digestive effects; papain is also used to hydrolyze animal and plant proteins, make meat tenderizer, high-grade oral liquid, soy sauce brewing and wine starter; papain is also used It can be used in soaps, soaps, detergents, washing powders, etc.; adding papain to cosmetics containing protein and oil has the effects of whitening and rejuvenating skin, beautifying and health-care, and improving skin; using papain to make depilatory agents has the effect of It has the effect of fine pores and bright skin texture; papain is also used as a feed additive, which can improve the utilization rate of feed. In addition to saving costs, it also helps the digestion of sexual animals and accelerates their growth.
food industry
Using the enzymatic reaction of papain, it can hydrolyze large-molecule proteins in food into small-molecule peptides or amino acids that are easy to absorb. It is widely used in animals and plants such as chickens, pigs, cattle, seafood, blood products, soybeans, peanuts, etc. Proteolysis, meat tenderizer, wine clarifier, biscuit loosening agent, noodle stabilizer, health food, soy sauce brewing and wine starter, etc., can improve the nutritional value of food and reduce costs.
Biscuit industry
It reduces the moisture content of the dough, improves the plasticity and physical and chemical properties of the dough, and at the same time hydrolyzes protein macromolecules into short peptides and amino acids, which facilitates the complex Maillard reaction of sugars and amino substances, making the product color fast and pleasing to the eye. It has an oily and fresh feeling, relatively loose and crispy content, obvious cross-sectional network structure and good layering; the rate of cracked and broken cakes is reduced, the shape of the cake is correct and full without shrinking, the pattern is clear, and the cake surface is smooth; and it can be reduced by 10 %-25% sodium metabisulfite, thereby reducing the residual amount of harmful substances such as SO2, and also correcting the impact of chemical additives on the flavor of biscuits, effectively improving the quality of biscuit products.
Pharmaceutical industry
Medications containing papain, such as papaya throat lozenges, papaya enteric-coated tablets (capsules), and papaya lozenges, have anti-inflammatory, choleretic, analgesic, digestive aid, and immune enhancement effects. Further research shows that they can also be used to examine the surface of red blood cells. And blood type identification agent, treatment of gynecological diseases, glaucoma, insect bites, etc.
Textile industry
Anti-shrinkage of wool: The tensile strength of wool treated with papain is higher than that of conventional methods. The wool feels soft, and the shrinkage of comfort, anti-shrinkage, tensile strength and other effects is 0; it can also be used for degumming of silkworms and degumming of silk. Refined.
Feed industry
Decompose the protein in the feed into amino acids, increase the leakage of nutrients, facilitate the absorption and utilization of eggs by poultry, and at the same time supplement the lack of endogenous enzymes in animals, improve feed utilization and reduce feed costs, enhance appetite, thereby promoting animal growth and improving Daily weight gain and viability, it can also be used as an additive for advanced compound fertilizers for vegetables and fruits.
Daily chemical industry
Used in soaps, soaps, detergents, washing powder, hand sanitizer, etc. After the clothes are contaminated by blood stains, milk, juice, soy sauce, grease, etc., it is generally difficult to remove these stains if ordinary detergents are used. If protease is added to the detergent, sweat stains and blood stains can be easily removed, with strong decontamination power, sterilization, and safety.
In addition, toothpaste, mouthwash, tooth powder, etc. can be added to clean the mouth, remove tartar and calculus, and can be used with other solvents to make contact lens cleaning and disinfectants and the recovery of photosensitive film silver.
Company introduction and certificates obtained
YTBIO mainly supplies Alpha Arbutin powder, etc.Professional Pure Papain powder suppliers.The company was established in 2014 and has many years of experience in R&D and production. We are committed to the R&D, production and sales of raw materials for the health industry in the 21st century. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA, etc. We always maintain the highest demands on product quality.
Our packaging
Our packing method is 1KG/Aluminium bags, 25kg/drum
For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin
Our team
Our team is professional, and our business team has undergone strict and professional product training. To ensure that our customers have a good cooperation experience and all questions during the cooperation process can be answered in a timely manner.
Factory
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