Silymarin Powder

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of silymarin powder in China. With abundant experience, we warmly welcome you to wholesale bulk silymarin powder for sale here from our factory. Quality products and reasonable price are available.

Silymarin powder is a natural flavonolignan, a natural active substance extracted from the dried fruits of milk thistle, a plant in the Asteraceae family. Silymarin is insoluble in water, easily soluble in acetone, ethyl acetate, methanol and ethanol, and slightly soluble in chloroform.

It is considered the most effective flavonoid found in the world for treating liver disease. It stabilizes liver cell membranes, maintains the integrity of liver cells, prevents toxins from penetrating and damaging the liver, and accelerates the synthesis of liver cells. DNA (deoxyribonucleic acid).

Silymarin originated in Europe and was introduced to China in 1972. It is a commonly used hepatoprotective drug. It is often used clinically to prevent and treat viral hepatitis, fatty liver, alcoholic liver and other liver diseases characterized by damage to liver tissue and function. Clinical studies have shown that it can reduce the damage caused by toxic substances to liver cells, inhibit inflammatory reactions, and also promote the repair of liver cells.

It is a naturally active substance that stabilizes the liver cell membrane and maintains its integrity. It works by promoting the restoration of the ultrastructure of liver cells and the division and growth of normal liver cells.

Silymarin can improve the synthesis ability of RNA and protein, the ability of the reticuloendothelial system to produce phagocytes, and at the same time strengthen its activity, accelerate the clearance of viruses, promote fat transfer and antioxidant effects, prevent excessive oxidation and infiltration of fat, promote liver metabolic function, and Enhance its detoxification effect to protect normal cells and promote the recovery of damaged cell membranes.

Due to the high nutritional value of milk thistle, many scientists have conducted in-depth research on it. Silymarin, which nourishes and protects the liver, is extracted from the herb plant milk thistle. According to research, milk thistle has a negative impact on liver cells. It plays an important role in repairing and regenerating liver fibrosis and improving liver function. It has been clinically proven that milk thistle has a significant effect on the treatment of liver damage and hepatotoxicity.

Scavenge reactive oxygen species: Directly remove reactive oxygen species, fight lipid peroxidation, and maintain the fluidity of cell membranes.

Hepatoprotective effect: Silymarin has a protective effect against liver damage caused by carbon tetrachloride, galactosamine, alcohols and other hepatotoxins.

Anti-cardiovascular disease effects: The effects of milk thistle extract on anti-high cholesterol and low-density lipoprotein oxidation were studied in mice. The mice were fed polyunsaturated fatty acids containing silymarin extract and a small amount of saturated fatty acids.

Compared with mice fed polyunsaturated fatty acids and a small amount of saturated fatty acids, the cholesterol content in the serum of the former was significantly reduced, VLDL hair was reduced, and HDL-C increased, indicating that silymarin improved the ability to resist LDL.

Protective effect on cerebral ischemic injury: A four-vessel occlusion method was used to create a rat model of global cerebral ischemia to explore the mechanism of silymarin's protective effect on cerebral ischemic injury. By observing the effects of silymarin on nitric oxide and nitric oxide in brain homogenate fluid, The expression of synthetic enzymes showed that silymarin significantly reduced the content of NO and NOS in the brain tissue of ischemic rats and significantly reduced the infarct area.

Antiviral activity

In terms of anti-virus, most anti-viral drugs or ingredients block the replication or spread of viruses at a single target or link, while silymarin and its derivatives can produce powerful effects by acting on multiple links in the virus life cycle. Antiviral activity.

For example, the most intensively studied currently is the hepatitis C virus (HCV). Silymarin can not only enhance the antiviral effect of the JAK-STAT signaling pathway, but also inhibit NS5B polymerase activity and inhibit the transcription of nuclear factor NF-κB, thereby blocking the virus from entering cells. and copy propagation.

For example, against influenza A virus, silymarin can inhibit the synthesis of viral RNA and virus replication in the late stages of infection. For dengue virus, silymarin and its derivatives have a very strong affinity with the virus's non-structural protein NS4B, so it can also be used as an anti-dengue virus target for treatment.

anti-inflammatory activity

[5-lipoxygenase] (5-LOX) is closely related to many inflammations, and because 5-LOX is expressed in various tissues and cells of the human body, it is now generally believed that 5-LOX is the inflammatory cascade reaction One of the originators of.

Silymarin happens to act on 5-LOX, thereby reducing the production of inflammatory mediators leukotrienes and lipoxins, and reducing inflammatory reactions.

Anti-oxidize effect

Silymarin can reduce the damage to cells caused by oxygen free radicals such as ROS and superoxide anions. Especially in the face of environmental stress such as drugs, silymarin can increase the production of glutathione and superoxide dismutase.

In addition, although long-term high sugar intake makes people feel happy, it may induce the production of large amounts of superoxide and cause damage to glomerular podocytes. Silymarin can start from two aspects. One is to enhance the activity of antioxidant enzymes in the kidneys, such as catalase and glutathione peroxidase, etc., and the other is to inhibit NADPH oxidase, thereby achieving the effect of protecting the kidneys.

anti-fibrotic effect

A large number of studies have shown that silymarin can inhibit the activity of NF-kB and block the signaling pathways of other protein kinases. Silybin supplementation inhibits procollagen production in activated hepatic stellate cells, thereby exhibiting significant anti-fibrotic effects.

Acts on the liver through intestinal bacteria

Long-term high-fat diet will greatly increase fat accumulation in the liver. Studies have shown that oral administration of silymarin can significantly change the structure of intestinal flora and greatly promote the colonization of related flora that can synthesize vitamin B12. The level of triglycerides in human serum is significantly negatively correlated with the content of VB12.

The advantage of this is that it can improve the level of fatty acid degradation in the liver, thereby improving the accumulation of liver fat caused by high-fat diet levels.

Pharmacological studies have shown that silymarin has obvious repairing and protective effects on liver cells. Its main mechanism of action is as follows.

1. It has an obvious protective effect on liver cells and can effectively reduce the damage caused by toxic substances to liver cells. Research shows that silymarin can bind to the cell membrane of liver cells, maintain the fluidity of the cell membrane by resisting lipid peroxidation, reduce the attack of toxic substances on the liver cell membrane, interrupt its transmembrane transport and intercellular spread, thereby effectively enhancing liver function. Cell resistance to a variety of toxic substances effectively protects the integrity of liver cells.

2. It has obvious anti-liver fibrosis effect, can effectively inhibit liver cirrhosis and preserve the normal function of the liver. Research shows that silymarin has significant anti-inflammatory and anti-oxidative stress activities. It can effectively regulate the synthesis and degradation of extracellular matrix components, inhibit the activation of fibrosis programs by inflammatory factors, thereby reducing the conversion of fibrinogen into fibrin and reducing the risk of fibrosis. Liver fibrosis, preserving the normal structure and function of the liver.

3. It can effectively promote the repair and regeneration of liver cells, thereby restoring the normal function of the liver. Studies have shown that silymarin can bind to the estradiol receptor on the surface of liver cells, pass through and activate the estradiol receptor, thereby enhancing the activity of RNA polymerase I in the nucleus of liver cells and promoting the synthesis of DNA, RNA and other substances in liver cells. , while promoting the synthesis of a variety of biological enzymes and structural proteins in cells, thereby effectively promoting the regeneration and repair of liver cells and restoring damaged liver cells to normal functions.

4. It has a certain inhibitory effect on hepatitis C virus. Hepatitis C virus is one of the common clinical viral hepatitis. It is mainly transmitted through blood. Research results show that silymarin can inhibit the activity of the polymerase by competing to bind to the active region of the non-structural region of the viral gene, thereby interfering with the activity of the hepatitis C virus. Assist and exert a certain antiviral effect.

Currently widely used in health care products, cosmetics field

Shaanxi Yuantai Biological Technology Co., Ltd. was established in 2014, mainly supplying Silymarin powder and so on. We have our own factory, R&D and quality inspection team, and have the conditions for development, production and quality assurance. At present, the company has passed ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certifications. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.

1KG/Aluminium bags , 25kg/barrel

Storage: Store in a cool, dry, clean place away from moisture and direct light.

We also have special packaging for special products, such as: retinal - cold chain transportation; deoxyarbutin - vacuum transportation

We have a professional R&D team and sales team, which not only ensure product quality, but also ensure a good cooperation experience for customers in the pre-sale, in-sale and after-sale processes. Our sales team has been trained in professional product knowledge, and can respond and solve every problem in cooperation in a timely manner

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