What is pyrroloquinoline quinone (PQQ)?
PQQ, full name 4, 5-dihydro-4, 5-dioxy-1-hydropyrrole (2, 3-f) quinolin-2, 7, 9-tricarboxylic acid, also known as pyrroloquinoline quineone (PQQ), is produced by Gram-negative bacteria, and has a wide range of nutritional effects on microorganisms, animals and plants. And have antioxidant nutrients.
Pyrroloquinoline quinone form：
In today's supplement market, there are two main types of pyrroloquinoline quinone or PQQ. One is pyrroloquinoline quinone disodium salt, the other is pyrroloquinoline quinone acid.
Mechanism of action of pyrroloquinoline quinone
Pyrroloquinoline quinone (PQQ) is a small quinone molecule that has a REDOX effect and can reduce oxidants (antioxidants); It is then recycled into its active form via glutathione. It appears to be relatively stable because it can go through thousands of cycles before depletion, and it is new because it is related to the protein structure of the cell (certain antioxidants, the major carotenoids (such as beta-carotene and astaxanthin) are located in specific regions of the cell where they proportionally play more of an antioxidant role). Because of its proximity, PQQ appears to act near proteins on the cell membrane, such as carotenoids.
Advantages of pyrroloquinoline quinone
Mitochondria being in condition is essential for healthy living, so taking ppq can experience many benefits. The following are some of the advantages of pyrroloquinoline quinones.
1. Increase cell energy
Since the mitochondria generate energy for the cell, and PQQ helps the mitochondria work more efficiently, the energy inside the cell is increased overall; This is the mitochondrial mechanism of pyrrolidoquinoline quinone. Unused cellular energy is diverted to other parts of the body. If your body has no strength all day, or if you feel tired or sleepy, increasing the intensity of your PPQ is crucial for you. One study found that subjects with energy problems experienced significantly less fatigue after taking PQQ. If you are looking for ways to increase your energy, PQQ may be able to help you.
2. Prevent cognitive decline
With the development of science, scientists discovered that nerve growth factor (NGF) can grow and recover. At the same time, PQQ has been shown to have a positive effect on NGF and increase nerve growth 40-fold. NGF is essential for the formation and maintenance of new neurons, and it can restore damaged neurons, thereby inhibiting cognitive function. Neurons are the cells that transmit information, so our brain can communicate between itself and the rest of the body. Improving the quality and quantity of neurons can improve cognition. As a result, PQQ has short-term improvements.
3. Support cardiovascular health
Pyrroloquinoline quinine provides antioxidant and mitochondrial support. Studies have shown that both PQQ and CoQ10 support myocardial function and appropriate cell oxygen utilization. Pyrroloquinoline quinones can prevent oxidative stress by rejuvenating them.
4. Other benefits
In addition to the three main benefits listed above, PQQ also offers other lesser-known benefits. PQQ may play a role in easing inflammation in the body, improving sleep and improving fertility, but more research is needed to draw definitive conclusions. As research progresses, more benefits of taking PQQ may be found.
Common application directions and potential applications of PQQ
1. PQQ+ Coenzyme Q10 (Heart health)
Both PQQ and Coenzyme Q10 are involved in the production of mitochondrial energy, and the combination of the two can achieve better results, and this combination is currently the most common combination of PQQ-related supplements, mainly used in heart health, energy supplement and brain health supplements.
2. PQQ+PS(Phosphatidylserine) (Brain Health)
Over time, the mitochondria of nerve cells in the nervous system and brain degrade. In addition to damaging memory and attention, mitochondrial degradation has been linked to diseases such as Alzheimer's and Parkinson's. Through mitochondrial regeneration, PQQ can help stop or even reverse this damage.
3. PQQ+NMN(β-Nicotinamide Mononucleotide) (Energy supplement)
PQQ and NMN are also a classic combination, both of which can promote mitochondrial energy supply and mitochondrial regeneration, and are often used in various supplements to delay aging and supplement cellular energy.
4. PQQ+GABA( γ-aminobutyric acid) (Sleep health)
PQQ can alleviate sleep disorders caused by anxiety by reducing the stress hormone cortisol, effectively reduce the time to fall asleep, and improve sleep quality. It can be combined with melatonin, GABA, L-theanine, valerian and other sleep AIDS.
5. PQQ+ collagen (oral beauty)
Helps slow skin aging, promotes collagen production, reduces pigmentation and wrinkles.
6. PQQ+ amino acids (reproductive health)
7. Other application directions
1) Hangover cure
Can be paired with raw materials: kudzu root, turmeric, probiotics, yellow grass, mussel meat polysaccharide, snake grape leaves, corn oligopeptide, hovenia hovenia
PQQ can accelerate the metabolism of acetaldehyde (an intermediate product of alcohol metabolism) in rats. During the hangover process, PQQ transfers the electrons removed from ethanol to ubiquinone (Coenzyme Q10), and then ubiquinone is reduced to ubiquinol, thereby reducing the toxicity of acetaldehyde to the liver, and playing the role of hangover protection.
2) Boost immunity
Can be paired with raw materials: Vitamin C, zinc, vitamin D, probiotics, prebiotics, turmeric, elderberry, lactoferrin, ginseng
PQQ can also support immune function, and lack of PQQ can lead to immune dysfunction. In one study, PQQ supplements increased the response of B and T cells (white blood cells that play a central role in the immune response) to mitogen (proteins that induce cell division, or mitosis).
Range of use and maximum usage:
Beverage (40mg/kg, solid beverage according to the quality of the liquid after mixing).
Infants, pregnant women and breastfeeding women should not be eaten, and the label and instruction manual should be marked with unsuitable people.
Production process:
Chemical synthesis
6-amino-5-methoxy-1H-indole-2-antelope ethyl ester and 2-oxopentenediate dimethyl ester were prepared by coupling ring reaction, quinoline ring formation, oxidation reaction, ester hydrolysis reaction and refining.
Microbial fermentation method, that is, glucosotrophus glucose-eating bacteria (Methylovorus glucosotrophus) as fermentation strains, after fermentation, extraction, purification, crystallization, drying and other processes.
Recommended dosage: ≤20 mg/day (that is, the recommended dosage of pyrroloquinoline quinone with 98% content is ≤20 mg/day, if it exceeds the content, it will be converted according to the actual content)
If you would like to learn more, please contact sales@sxytbio.com,Click here to contact us online
