Peptide is a small molecule protein, also known as polypeptide or peptide. It is composed of amino acids with a certain sequence connected through amide bonds. Those composed of 2 amino acids are called dipeptides, and those composed of 3 amino acids are called tripeptides. in turn. Peptides play important roles in the growth, development, and metabolism of organisms. Almost all physiological processes in the human body are regulated by polypeptides or proteins composed of specific amino acid sequences. In the natural aging and care process of skin, peptides play an important role, such as cell proliferation, cell migration, inflammation, angiogenesis, pigment formation, and protein synthesis and regulation. According to the survey, the peptides currently used most frequently by famous foreign brands are: palmitoyl pentapeptide-3 (pentapeptide), acetyl hexapeptide-3, acetyl tetrapeptide-5, palmitoyl oligopeptide ( There are more than 500 search results for these beauty peptides used by various brands, such as palmitoyl tripeptide-1), palmitoyl tetrapeptide-3 and carnosine, which shows that they are widely used.
Beauty peptides can penetrate the dermis to increase collagen and reverse the skin aging process by rebuilding it from the inside out. Beauty pentapeptide is also a kind of beauty peptide. The prototype of the peptide is palmitic acid pentapeptide, commonly known as pentapeptide, which can simulate the paralysis effect of botulinum toxin. It is a short peptide fragment composed of five amino acids formed by peptide bonds. Its structure is similar to that of protein, but the peptide chain of protein is longer, usually composed of hundreds of amino acids. These polypeptides can be divided into dipeptides (containing two amino acids), tripeptides (containing three amino acids), tetrapeptides (containing four amino acids), etc. according to the number of amino acids they contain. And due to the different types of amino acids they contain , there are different varieties of dipeptides, and the same is true for tripeptides; at the same time, with the same several amino acids, but the order (link) of each amino acid is different, there will be different varieties of dipeptides. So there are now peptides with various functions and names. Pentapeptide is composed of six amino acids (Pal-palmitic acid, Lys-lysine, Thr-threonine, Thr-threonine, Lys-lysine, Ser-serine). Beauty Pentapeptide is actually the C-terminal fragment of collagen I, which has an effect similar to that of laser surgery. Stimulates the proliferation of collagen, elastic fibers and hyaluronic acid, increases skin's moisture content and moisture retention, increases skin thickness and reduces fine lines; at the same time, the addition of a long-chain fatty acid (palmitic acid) can increase the absorption effect. Compared with laser surgery, Palmitoyl Pentapeptide-4 are equivalent to intimate integration with the skin, changing the skin's ecology and cell repair, and playing the role of intracellular hormones and enzymes.
Pentapeptide has only 13 amino acids, has a small molecular weight and is easily absorbed. One of its significant effects is that it can promote collagen proliferation and indirectly repair micro-damage to the human oral mucosa. The anti-aging effect of Palmitoyl Pentapeptide-4 can prevent and improve gum recession. In addition, Palmitoyl Pentapeptide-4 can promote the proliferation of hyaluronic acid and elastic fibers, and can effectively activate the synthesis of hyaluronic acid, which is crucial for maintaining oral moisture and relieving dry mouth.
What are the effects of peptides on the skin?
Many people accelerate skin aging due to stress. The key reason is the reduction of coenzyme NAD+. It greatly aggravates the damage of free radicals to "fibroblasts", which are responsible for the production of collagen. Among the anti-aging ingredients, there is a very popular king ingredient - peptides, which can mobilize the enthusiasm of "fibroblasts" and accelerate the production of collagen.
For some "peptides" to work (such as hexapeptides), they need to penetrate the stratum corneum, epidermis, dermis, fat layer, and finally act on the muscle layer. Among all the peptides, "Palmitoyl Pentapeptide-4" directly acts on the dermis layer of the skin. It does not require injection, it can work just by smearing it, which is more direct and more effective.
The dense keratin of the skin blocks skin care factors from penetrating into the dermal layer of the skin, so most skin care products only stay on the surface of the skin. The bioactive Palmitoyl Pentapeptide-4 can enter the dermis, promote collagen proliferation, increase skin moisture content, increase skin thickness and reduce fine lines.
In addition, antioxidant and collagen protection are inseparable from the all-round player "niacinamide". In addition to sun protection, you can also use some antioxidant ingredients, such as nicotinamide, which can also stimulate the production of collagen. If niacinamide is added to skin care products, it is almost a given that it can repair the skin barrier and improve the skin's ability to protect against external aggression.
To sum up, pentapeptides and nicotinamide can promote collagen production and resist oxidation, thereby delaying skin aging and improving skin firmness. Pentapeptides are also often added to many anti-aging skin care products, and when paired with niacinamide, they can have a brightening and firming effect.
The difference between Palmitoyl Pentapeptide-4 and Argireline
Although Palmitoyl Pentapeptide-4 and Palmitoyl Pentapeptide-4 sound similar, the two ingredients or concentrations and the effects they can exert may be different. Five-peptides can mainly effectively promote collagen or elastic fibers and hyaline. The proliferation of acid has a very good effect on increasing the moisture content of the skin and increasing the thickness of the skin. Hexapeptide can also effectively block nerve transmission, which is very good for reducing expression lines or wrinkles and smoothing crow's feet. Effect.
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