What Is Glycyrrhetinic Acid Used For?

Licorice (Glycyrrhize glabra L.) is a common food and medicine. Licorice extract is widely used in candies and canned foods as a natural sweetener. The sweetness of licorice comes from glycyrrhizic acid and glycyrrhetinic acid. The former is a type of triterpenoid saponin, accounting for about 4% to 5% of the dry weight of licorice root, and its sweetness is 50 times that of sucrose. Glycyrrhetinic acid is formed by hydrolyzing glycyrrhizic acid to remove the sugar acid chain, and its sweetness is 250 times that of sucrose.

Glycyrrhetinic acid (Glycyrrhetinic acid), is a triterpene saponins, which is different from glycyrrhetinic acid in that two glycosides are missing and also exist free in licorice root. Glycyrrhiza uralensis is a major active ingredient in the roots and rhizoma of the legume Glycyrrhiza uralensis. Glycyrrhetinic acid is an important cosmetic raw material, which is used as a skin conditioner in cosmetics. It can be applied to a variety of functional cosmetics to adjust the skin.

Glycyrrhizic acid extracted from the rhizome of legume base grass is prepared as ammonium salt and then hydrolyzed. Licorice is my annual herb, mainly produced in Inner Mongolia and Gansu and other places. The root and rhizome of licorice mainly contain glycyrrhizin, which is the potassium and calcium salt of glycyrrhizic acid and is the sweet component of licorice. It is about 50 times sweeter than sucrose. The pulverized licorice was heated with water and extracted continuously against the current to separate and remove the grass residue impurities and obtain an aqueous solution. Evaporate, concentrate, and add sulfuric acid pH2-3 under stirring. The precipitate was allowed to stand and the supernatant was removed. The precipitate was washed with water, concentrated by heating, and boiled to make glycyrrhizic acid paste. The glycyrrhizic acid paste was crushed and extracted with 95% ethanol for 2-3 times, 3h each time, to obtain an ethanol solution. After filtration, ammonia was stirred to pH 7-7.5. After filtration, the crude triammonium glycyrrhizinate was obtained and refined with glacial acetic acid, which was beige monoammonium glycyrrhizinate. Monoammonium glycyrrhetinic acid was added to 5% aqueous sulfuric acid solution, heated to near boiling by stirring, hydrolyzed by reflux for 15h, filtered and washed to obtain crude glycyrrhetinic acid. After recrystrystalization and decolorization, the content of rheooxalic acid was more than 92%. The total yield was about 0.5% based on licorice.

1. Anti-inflammatory

Glycyrrhetinic acid is the main component in licorice, which has a strong anti-inflammatory effect. Glycyrrhetinic acid has a good anti-inflammatory effect on a variety of inflammatory diseases, such as respiratory tract infection, digestive tract infection, skin infection, etc.

2. Anti-allergic

Glycyrrhetinic acid has a good anti-allergic effect on a variety of allergic diseases, such as allergic rhinitis, allergic dermatitis, urticaria, etc.

3. Protect the liver

Glycyrrhetinic acid also has a hepatoprotective effect, because glycyrrhetinic acid can promote the regeneration of liver cells, thereby improving liver function and protecting the liver.

4. Anti-virus

Glycyrrhetinic acid also has an antiviral effect, because glycyrrhetinic acid can inhibit the growth of the virus, and can also play an antiviral role, to prevent the occurrence of a variety of viral infectious diseases.

5. Immune regulation

Glycyrrhetinic acid can promote the differentiation of T lymphocytes, and can also promote the proliferation of B lymphocytes, so as to achieve the role of immune regulation.

1. Sweetener; Sweet taste improver; Flavoring agent (with salt application, the effect is particularly large);

2. Flavor enhancer (dairy products, cocoa products, egg products, mutton, etc., in addition to the smell of mutton). Our country folk used in sauce and sauce products, pickled products and so on.

3. "Antibiotics used to treat infections of Staphylococcus, streptococcus, Escherichia coli, and Helicobacter, etc.

4. Can be used in cream, cream, toner, lotion, essence and other kinds of cosmetics, also suitable for hair care products and tooth care products (toothpaste, mouthwash, etc.). The recommended dosage is 0.3%-2%.

Glycyrrhizic acid market future trends Natural medicine and health products market demand increase: With the increase in the demand for natural plant extract raw materials and the improvement of the awareness of the preserved products, the application prospect of glycyrrhizic acid is also enhanced. Glycyrrhizic acid market prospect analysis predicts that the global natural medicine and health products market is expected to continue to grow in the next few years. This will provide more opportunities for the glycyrrhizic acid market.

The pharmaceutical market is expanding: Glycyrrhizic acid has a wide application prospect in the pharmaceutical field, with anti-inflammatory, anti-ulcer, increasing immunity and other effects. With the aging of the population and the increase of disease burden, the pharmaceutical market is expanding, which will provide more market opportunities for glycyrrhizic acid.

Huge demand in Asian market: There is a large demand for traditional Chinese medicine ingredients in Asia. Glycyrrhizic acid, as an important ingredient in Chinese medicine, has a broad market prospect in the Asian market. Especially in Asian countries such as China, Japan, and South Korea, there is a huge demand for glycyrrhizic acid and these markets will be an important growth driver for the glycyrrhizic acid market in the coming years.

Application of new technologies to promote market development: Analysis of glycyrrhizic acid market prospects mentioned that (with the continuous development of science and technology, the application of new technologies will also promote the development of glycyrrhizic acid market. For example, glycyrrhizic acid synthesis technology based on biotechnology and the application of nanotechnology in glycyrrhizic acid are expected to bring more development opportunities to the glycyrrhizic acid market.

Medical field: Glycyrrhizic acid, as an important natural medicinal ingredient, has been widely used in the research and development of traditional Chinese medicine and modern drugs. It has anti-inflammatory, anti-oxidation, antibacterial, antiviral and other pharmacological effects, and can be used to treat digestive system diseases, respiratory system diseases, etc. With the increasing demand for natural medicines, the market demand for glycyrrhizic acid in the pharmaceutical field will continue to grow.

Health care products: With the improvement of people's health awareness, health care products extracted from natural plants are favored. Glycyrrhizic acid has functions such as regulating the immune system, anti-fatigue, and anti-inflammation, so it also has great market potential in the field of health products.

Cosmetics: Glycyrrhizic acid has anti-oxidation, whitening, anti-aging and other effects, so it is widely used in skin care products and whitening products. With the consumer preference for natural plant-derived raw materials, glycyrrhizic acid is also expected to be more used in the cosmetics field. Market scale expansion; With the increasing demand for natural medicines and health products in the global scope, the glycyrrhizic acid market will gradually expand. In particular, there is a huge demand for Chinese herbal medicine ingredients in Asia, thus the region is expected to be one of the major growth drivers for the glycyrrhizic acid market.

In general, glycyrrhizic acid, as an important bioactive ingredient, has a broad market prospect in the fields of medicine, health care products, cosmetics and so on. As people pay more attention to health and the popularity of natural plant-derived raw materials continues to increase, the glycyrrhizic acid market will welcome more development opportunities.

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