Pterostilbene, also known as 3, 5-dimethoxy4 '-hydroxystilbene, (E)-3, 5-dimethoxy4' -hydroxystyrene, (E)-4-[2-(3, 5-dimethoxyphenyl) -vinyl] -phenol and 4-[(1E)-2-(3, 5-dimethoxyphenyl) -vinyl] -phenol, are active ingredients derived from plants such as rosewood, blueberry, grape, and palmetto. Pterostilbene has anticancer, anti - inflammatory, anti - oxidation and analgesic effect. At present, a large number of studies have shown that Pterostilbene has a good effect in the treatment and protection of skin diseases, especially in the field of anti-oxidation.
As an antioxidant, pterostilbene can resist cell proliferation, reduce blood lipid, inhibit COX-1 and COX-2, and fight against cancer and fungi.
1.Pterostilbene helps prevent pre-cancer damage to the body. As an antioxidant and anti-inflammatory agent, they are found in both blueberries and blackberries.
2.Pterostilbene and quercetin inhibit the growth and metastasis of metastatic melanoma by inhibiting the expression of adhesion molecule 1 in rat hepatic sinusoidal endothelial cells, thereby reducing the adhesion of B16M-F10 cells to endothelial cells, while inhibiting the expression of bcl-2 in metastatic cells and reducing the cytotoxicity of vascular endothelial cells. At the same time, Pterostilbene significantly inhibited the activation of NF- B and activator protein 1 induced skin tumors.
3.Pterostilbene has the ability to inhibit the activation of nuclear factor NF- B, thereby inhibiting the activation of pro-inflammatory cytokines and nitric oxide synthase genes, leading to decreased secretion of tumor necrosis factor, interleukin1, interleukin6 and nitric oxide, thereby reducing the inflammatory response.
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