Honokiol is a biphenol compound, which is one of the main active components of magnolia officinalis. The active components of magnolia officinalis are mainly phenolic compounds (mainly magnolol and magnolol) extracted from the bark and bark of magnolia officinalis.Magnolia officinalis is the bark, root bark and branch bark of Magnolia Officinalis and Magnolia Lushan. The main components of magnolia officinalis extract are honokiol, honokiol and honokiol. The main components of the essential oil of Magnolia Officinalis oil are eudinol. The alkaloids in Magnolia Officinalis extract are honokiol. At present, the main active ingredients extracted are magnolia officinalis, honokiol and honokiol. At the same time, magnolia officinalis is also commonly used in cosmetics as a broad spectrum antibiotic, antibacterial whitening and natural preservative.
The main components of Magnolia officinalis:
Lignan compounds: magnolol, honokiol, obovatol, 6 '-o-methyl and 6' -O-methylhonokiol, etc.
Alkaloids: magnocurarine and salicifoline;
Volatile oil: contains more than 30 components, the main are β-eudesmol 17.4%, cubeb alcohol (cadinol) 14.6%, guaiol (guaiol) 8.7% and so on.
It also contains sinapicaldehyde, syringaresinol, syringaresinol -4 '-o-β-D-glucopyranose and so on.
The main components of magnolia officinalis extract are magnolol, magnolol and magnolol
The main component of the essential oil of magnolia officinalis is eudinol
The alkaloids in the extract of magnolia officinalis are magnolia officinalis。
Study on biological activity of extracts from Magnolia officinalis
1, antibacterial effect Magnolia officinalis extract is a pure natural broad-spectrum antibiotic
The extract of Magnolia officinalis has antibacterial effect and its antibacterial components are stable. In vitro experiments showed that the extract of Magnolia officinalis had inhibitory effects on pneumococcus, hemolytic streptococcus, staphylococcus and Escherichia coli.
Magnolol has a strong antibacterial effect on dysentery bacillus, typhoid bacillus and caries bacteria, especially on caries bacteria.
Magnolol and magnolol have anti-fungal effects on various pathogenic fungi, and can significantly inhibit human candida albicans, Aspergillus nigricans, epidermosis floccus, trichophyton flavus, microsporum gypsiformis and other pathogenic fungi. The antifungal activity of magnolol was higher than that of streptomycin sulfate, and the antifungal activity of palpophyton was higher than that of amphotericin B.
2, Natural preservatives
Magnolia officinalis extract has the characteristics of high inhibition of various bacteria, fungi, and low toxicity. At the same time, magnolol was added to the cream to test its actual antibacterial and preservative effect. The results showed that the aroma of the product after adding magnolol was normal, and the pH was about 6.2, which was within the normal range. The cold and heat resistance experiments showed that the formula had good stability, which proved that magnolol had good compatibility when used as a preservative.
3. Muscle relaxation
Magnolia officinalis extract can play a strong antispasmodic effect. Has a special and long-lasting muscle relaxation effect.
4. Effect on digestive tract
Magnolia officinalis and its volatile oil taste bitter can stimulate the taste, reflex cause saliva, gastric secretion, gastrointestinal peristalsis speed up, and have the effect of strengthening the stomach and helping digestion.
5, Anti-ulcer effect
The anti-ulcer and anti-secretion effects of magnolol can be partly attributed to its central inhibitory effect.
6. Effect on cardiovascular system
Magnolol, magnolol and magnolol can inhibit the absorption of cholesterol and play a preventive role in atherosclerosis.
Magnolol has strong antioxidant and free radical scavenging activities, suggesting that the cardioprotective ability of magnolol may be related to its antioxidant ability and inhibitory ability on granulocytes.
Honokiol and honokiol have anti-arrhythmia effect.
7. Protective effect on cerebral ischemia
8. Magnolia officinalis extract has a preventive effect on light skin aging (anti-inflammatory, anti-allergic, anti-bacterial)
9. Magnolia magnolia active ingredients play an antioxidant role by scavenging oxygen free radicals, and magnolia magnolia extract has a strong antioxidant effect.
10. Honokiol and honokiol have anti-anxiety effects, and honokiol is stronger than honokiol.
Honokiol can also be used as an antioxidant and skin whitening agent.
Magnolol can also be used as a skin whitening agent.
Magnolol has strong antibacterial properties, and can also be used as a natural preservative when added to cosmetics. It has strong inhibitory effect on Pseudomonas aeruginosa, Typhoid, typhoid, Staphylococcus aureus, Escherichia coli and so on.
Daily chemical washing application
1, used in chewing gum, toothpaste, mouthwash products, to prevent dental plaque and gingivitis, anti-caries, anti-bad breath;
2, used for shampoo, can stop dandruff to itch, healthy hair follicles
3, used in shower gel, can be antibacterial, whitening, itching
Cosmetic applications
1, and honokiol antibacterial properties can be used as a cosmetic preservative
2, whitening spot water, cream, cream, mask
3, acne anti-inflammatory cream, cream, mask
[Add suggestion] The maximum add amount of 8% refer to the Food and Drug Administration {2012} cosmetic addition standard
Magnolia officinalis extract and honokiol 1-98%
The efficacy of honokiol was compared with that of magnolol:
Magnolol has obvious and lasting central muscle relaxation, central nervous inhibition, anti-inflammatory, antibacterial, disease resistance to pathogenic microorganisms, anti-ulcer, anti-oxidation, anti-tumor, inhibition of morphine withdrawal, inhibition of platelet aggregation and other pharmacological effects. Magnolol is used in the treatment of acute enteritis. Bacterial or amoebic dysentery. Chronic gastritis, etc. In terms of antibacterial activity, magnolol had significant antibacterial activity against Gram-positive bacteria, acid-resistant bacteria and filamentous fungi, had more significant antibacterial effect on Streptococcus mutans, and had the strongest inhibitory effect on staphylococcus.
And honokiol can be used as antibacterial agents (gram-negative bacteria and acid-fast bacteria), can be used to prevent acne; Oral hygiene products to prevent dental caries, inhibit tooth decay; The inhibition of honokiol on NF-cB cells can improve the function of skin immune cells and have anti-inflammatory effects. Honokiol can also be used as an antioxidant and skin whitening agent.
Honokiol and honokiol have antibacterial and anti-inflammatory activities, and the efficacy is very similar. However, the difference between the two is reflected in that magnolol is more irritating than magnolol in daily cosmetics, so in the actual use process, and magnolol is more favored by formula engineers. From the raw material content to the crude extract of Magnolia officinalis, the content ratio of the two active ingredients is about 1:1. High monomer magnolol and honokiol were prepared after extraction and separation by modern technology. The purity has been greatly improved, but the scope of use has also been limited, the irritation of magnolol to the product has been highlighted, and the price of a single product of magnolol 98% has increased.
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