Description:
Aloe-emodin is an anthraquinone compound with the chemical formula C15H10O5. It is mainly derived from the dried roots and rhizomes of the Polygonaceae plant Rheum tanguticum Maxim.ex Balf or Rheum officinale Baill.
Aloe-emodin is the active antibacterial component of rhubarb. Bacteria that are sensitive to it include Staphylococcus, Streptococcus and diphtheria, subtilis, anthrax, paratyphoid and dysentery, among which Staphylococcus and Streptococcus are the most sensitive.
Source:
The rhizome of Rheum palmatum L., the rhizome of medicinal Rhubarb R. officinale Baill., the rhizome of Rumex patientia L., the leaves of R. dentatus L., the leguminous plant Lentil. The roots of Cassia mimosoides L., the seeds of C. tora L., the seeds of C. occidentalis L., the fruits of Rhamnus davurica Pall, the lily plants Aloe vera and zebra. Aloe vera aloe vera.
Physical properties:
Orange needle-like crystals (toluene), or earthy yellow crystalline powder. Melting point 223~224°, easy to sublimate. Soluble in acetaldehyde, benzene, hot ethanol, dilute ammonia, sodium carbonate and sodium hydroxide aqueous solution. Easily soluble in hot ethanol. It appears yellow in ether and benzene, and crimson in ammonia and sulfuric acid.
Preparation method:
Aloe-emodin can be obtained by extracting the crude product from the low-temperature drying of aloe juice with ethyl acetate, and then purifying it through silica gel column chromatography (petroleum ether-ethyl acetate).
Antibacterial activity
At a concentration of 1.5 to 25 mg/ml, aloe-emodin has inhibitory effects on Staphylococcus aureus, Streptococcus aureus, Bacillus diphtheriae, Bacillus subtilis, anthrax, Bacillus paratyphoid, and Shigella dysenteriae, among which Staphylococcus and Streptococcus are the most sensitive and antibacterial. The effective concentration is 15-25ug/ml. The in vitro inhibitory concentrations for Staphylococcus aureus 209P, Escherichia coli, and Shigella flexneri are 7.5 mg/L and 600 mg/L respectively. Their antibacterial effects are bacteriostatic rather than bactericidal. One of its mechanisms of action is to inhibit mitochondrial respiratory chain electron transport.
Aloe-emodin has a strong inhibitory effect on the nucleic acid and protein synthesis of Staphylococcus aureus. Aloe-emodin has a strong inhibitory effect on common clinical anaerobic bacteria. Among them, it can inhibit the growth of 90% to 100% of common Bacillus fragilis strains, and its MIC is slightly higher than that of metronidazole. At a concentration of 8 μg/ml, 76% to 91% of anaerobic bacteria can be inhibited.
Immunosuppressive effects
Aloe-emodin can inhibit the production of biological antibodies, inhibit the ability of carbon particles to clear away, reduce the weight of immune organs, reduce the number of white blood cells, and reduce the function of peritoneal macrophages. In vitro, it has a significant inhibitory effect on the incorporation of [3H]-TDR and [3H]Urd into lymphocytes at a concentration of 100 μg/ml.
purgative effect
Aloe-emodin has strong purgative activity. Intestinal bacteria metabolize aloe-emodin, rhein, and rhein-anthrone, and the latter has strong purgative effect. Clinically used as a laxative, it has the effects of increasing appetite and relieving large intestine. According to foreign medical reports, aloe glycoside is hydrolyzed into aloe-emodin under the action of parasitic bacteria in the human body. This aloe-emodin stimulates the peristalsis of the intestinal wall. At the same time, due to the change in osmotic pressure, it is conducive to the elimination of waste in the intestine, thereby achieving irritation. Laxative, this stimulating purgative effect has special effects on constipation and hemorrhoids. Especially for middle-aged and elderly constipation, the therapeutic effect is more obvious.
Effects of aloe emodin on skin
Composition and function of aloe vera Aloe vera contains aloe-emodin, aloe-emodin glycoside, and isomers of aloe-emodin glycoside, aloe-emodin glycoside. Aloe vera has antiseptic, anti-inflammatory, disinfectant and analgesic effects, and can be used to make medicines. Aloe vera contains many ingredients that are beneficial to the human body, which can delay aging and enhance immunity. It can also help hydrate the skin, and has effects such as sun protection and freckle removal.
Market potential
1. Improvement of health awareness Currently, health has become an issue that people pay more and more attention to. People not only pursue material comfort, but also pay attention to physical health. As a natural health care product, aloe-emodin meets the health needs of modern people and has broad market prospects.
2. Population aging. With the seriousness of population aging, the health problems of the elderly have also received increasing attention. Aloe-emodin has the functions of anti-aging and promoting liver function, which is very beneficial to the health of the elderly. Therefore, as the elderly population increases, the market potential of aloe-emodin is also growing.
3. Scientific and technological progress. With the support of science and technology, the application fields of aloe-emodin will become more and more extensive. For example, aloe-emodin can be used in many fields such as cosmetics, health products, and food. The development of these fields will promote the development of the aloe-emodin market.
International market expansion
With the continuous advancement of international trade liberalization, companies must have advanced technology and high-quality products if they want to gain a foothold in the international market. Therefore, companies must continue to strengthen technological innovation, improve product quality, make full use of overseas markets, and expand market share. To sum up, the market prospects of the aloe-emodin industry are promising, but the market competition is fierce. Enterprises must strengthen technological innovation, launch high-quality differentiated products, and continuously expand overseas markets in order to succeed in the fierce market competition.
If you would like to learn more, please contact sales@sxytbio.com，Click here to contact us online
