Product introduction about levulinic acid
The main function so flevulinic acid in cosmetics and skin care products are preservatives,emollients,and pHre gulators.The risk factoris1,which is relatively safe and can be used with confidence.Generally,it has no effect on pregnant women.Levulinic acid is not acne-causing.
Levulinic acid is an organic acid,which mainly prolongs the shelf life by inhibiting the growth of aerobic microorganisms.
Product Name:Levulinic acid
Structural formula:
CAS number:123-76-2
Melting point:30-33°C(lit.)
Boiling point:245-246°C(lit.)
Density:1.134g/mLat25°C(lit.)
Recommended dosage in cosmetics:
Leave-oncategory (such as toner,face cream,essence...):The results of the CIR safety assessment show that this ingredient is safe when it is formulated to be non-irritating and the concentration in theleave-onproductdoesnotexceed0.0005%.
Rinsetype (facial cleanser,shower gel...):CIR safety assessment results show that this ingredient is safe when used in aconcentration of no more than 4.5% in rinse-off products when it is formulated to be non-irritating.
application:
Levulinic acid is a multifunctional compound containing carbonyl, α-hydrogen and carboxyl groups at the same time. It is the basic raw material for the synthesis of various light chemical products. It has wide application value in organic synthesis, industry, agriculture and medicine. The acid hydrogenation product γ-valerolactone is a high-grade solvent and can be used as an intermediate product for the production of synthetic rubber, cold-resistant plasticizer and surfactant. Chlorinated levulinic acid can be used as a bacteriostatic agent in industrial circulating water. In agriculture, the amine salts of chlorinated levulinic acid can be used as herbicides and defoliants. In medicine, anti-inflammatory drugs and intravenous injections can be prepared from levulinic acid by deep hydrolysis of starch, glucose and cellulose raw materials. Usually heated in the presence of hydrochloric acid (or sulfuric acid) or other hydrolysis catalysts through the step of generating 5-hydroxymethylfurfural, and then decomposed by 5-hydroxymethylfurfural to obtain levulinic acid, concentrated by filtration, and then distilled under reduced pressure or extraction method to make finished products
It can be reacted as carboxylic acid and ketone, and various products can be obtained through esterification, halogenation, hydrogenation, oxidative dehydrogenation, condensation and other chemical reactions. Such as plastic modifiers, solvents, pharmaceuticals, industrial chemicals, spices, pesticide intermediates, organic synthesis intermediates, polymer additives, lubricating oil additives, surfactants, printing inks, rubber additives, cosmetic additives (including Shampoo, toiletries), etc.
Raw materials
Starch, glucose, cellulose raw materials, etc., hydrochloric acid or sulfuric acid, organic solvents (for extraction process)
Production method
Levulinic acid can be obtained by hydrolyzing cottonseed hulls or corn cob residues (furfural residues) or waste potato residues under pressure with dilute acid. Add furfural slag to 10% dilute hydrochloric acid, and its solidified solution is 1:1.75. After mixing evenly, put it into a hydrolysis pot, and cook it with 0.2MPa pressure steam for 8-10h. Then the dilute solution after hydrolysis is filtered and concentrated to a concentration of about 50%. Then carry out rectification under reduced pressure, and collect the distillate above 130°C (2.67kPa) to obtain the finished product. Raw material consumption quota: sweet potato slag 7000kg/t, Chemicalbook hydrochloric acid (100%) 1800kg/t. Another preparation method is obtained by rearrangement and hydrolysis of sugar alcohols. Add 4% hydrochloric acid solution into the reaction pot, stir and heat to 97-100°C, and slowly add the mixture of furfuryl alcohol, ethanol and water. After addition, stir for another 30 minutes. After filtration, the filtrate was concentrated under reduced pressure at 80°C (21.3kPa) to obtain crude levulinic acid liquid. Then distill under reduced pressure, collect 160-170°C (2.67kPa) fractions, and re-distill once again to obtain refined levulinic acid with a yield of about 75%.
Toxic protection
This product has low toxicity. Packaging, storage and transportation are packed in plastic barrels and reinforced with wooden boxes. Store in a cool, dry, ventilated place. Keep away from sources of ignition. Store and transport according to the regulations of flammable chemicals.
Also known as L-gluconic acid, fructose acid, gamma-pentanoic acid
Molecular formula: C5H8O3
Molecular weight: 116.12 (according to the 1997 International Atomic Weight Table)
Properties: white flaky crystal or colorless to light yellow transparent liquid, hygroscopic, easily soluble in water, alcohol, ether, ketone and aromatic hydrocarbon, etc., insoluble in aliphatic hydrocarbon.
properties and stability
1. White flake or frond crystal, flammable. Soluble in water; Alcohol; Ether organic solvents, insoluble in aliphatic hydrocarbons. Atmospheric distillation hardly decomposes, but it loses water and generates unsaturated γ-lactone when heated for a long time. It is hygroscopic, and its aqueous solution is more acidic than acetic acid.
2. Chemical properties: It can react with ketones and acids. React with hydrazine to generate hydrazone; react with base to generate salt; react with alcohol to generate ester, etc. Oxidation, reduction, and halogenation reactions can also occur.
3. It exists in flue-cured tobacco leaves, Burley tobacco leaves and smoke.
Spill emergency treatment:
1. Protective measures, protective equipment and emergency procedures for operating personnel. Use personal protective equipment. Avoid dust generation. Avoid breathing vapour, mist or gas. Ensure adequate ventilation. Evacuate personnel to a safe area. Avoid breathing dust.
2. Environmental Protection Measures
Do not allow product to enter drains.
3. Containment and removal methods of leaked chemicals and disposal materials used
Do not generate dust during collection and disposal. Sweep up and shovel up, place in suitable closed container for disposal.
application:
Levulinic acid has a wide range of applications. Levulinic acid can be used as carboxylic acid and ketone to react, through esterification, halogenation, hydrogenation, oxidative dehydrogenation, condensation, etc., to produce various products, including resins, medicines, spices, solvents, coatings and inks, Rubber and plastic additives, lubricating oil additives, surfactants, etc. In the pharmaceutical industry, its calcium salt (calcium fructonate) can be used to make intravenous injections. As a nutritional medicine, it helps the formation of bone and maintains the normal excitability of nerves and muscles. It is also used to produce indomethacin and plant hormones. Bisphenolic acid produced from levulinic acid can be used to produce water-soluble resin, which is used in the paper industry to produce filter paper. Levulinic acid is also an intermediate of pesticides and dyes.
Use limit FEMA (mg/kg): beverages, cold drinks, 14.0; candy, bakery products, 53.0; gelatin jelly, pudding, 4.0. FDA, § 172.515 (2000): Appropriate amount is limited.
Content analysis
Accurately weigh about 1.0g of the sample, put it into a 250ml Erlenmeyer flask containing 75-100ml of water, add phenolphthalein test solution, and titrate with 0.5mChemicalbookol/L sodium hydroxide until pink color begins to appear and last for 15s. Each Ml0.5mol/L sodium hydroxide solution is equivalent to 58.08mg of this product.
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