Phloretin is a plant polyphenol of dihydrochalcone, which can be extracted from apples and can play a role in protecting plants from UV damage.
For human skin, it has strong antioxidant and photoprotective effects (can eliminate UV-induced increase in free radicals in the skin and damage to cells and DNA) in addition to inhibiting matrix metalloproteinases (MMP- 1) and the activity of elastase, which can degrade the connective tissue of the skin and play an important role in the process of skin photoaging.
Related research
With the increase in the market share of pure natural functional cosmetic raw materials, phloretin has attracted widespread attention for its multi-functional cosmetic effects. After research, it has been found that it has antioxidant, anti-inflammatory, immunosuppressive and other pharmacological effects. In the field of cosmetics, it has the functions of whitening and removing acne.
1. The ability to inhibit mitochondrial lipid peroxidation and scavenge DPPH free radicals and ABTS free radicals. Good free radical scavenging effect has great application prospects in anti-aging cosmetics.
2. It can prevent carbohydrates from entering epidermal cells, inhibit excessive secretion of skin glands, and treat acne with strong secretion. At the same time, entering the cell can significantly reduce the activity of COX-2 promoter, inhibit the production of prostate E2, and relieve the inflammatory response of acne-type skin. .
3. Not only can directly absorb ultraviolet rays, but also can enhance the expression of nucleotide excision repair genes, slow down the formation of pyrimidine dimer, glutathione degradation and cell death induced by UVB, and reduce the damage of ultraviolet rays to keratinocytes.
4. A natural, safe and effective lipophilic compound, which has a certain effect of promoting penetration, and can be added to cosmetics as a carrier of effective active ingredients to promote the transdermal absorption of active ingredients and make them exert better effects.
5. With the in-depth research on the bacteriostatic effect of phloretin, it may be developed as a new natural bacteriostatic agent to be added to cosmetics to replace some chemical preservatives, and can also be added to acne-removing cosmetics as a functional raw material.
6. Compounding with common tyrosinase inhibitors can greatly improve the inhibition rate, and achieve 100% inhibition effect well. In addition, the inclusion complex of hydroxypropyl cyclodextrin and phloretin also has a good inhibitory effect on tyrosinase activity.
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