Sesamin, a lignin compound, is a natural antioxidant and the main active ingredient in sesame seeds or seed oil of the flax family.
In addition to sesame from the family Flaxaceae, sesamin has also been isolated from a variety of plants, such as: Asarum from the genus Asarum from the Aristolochiaceae family, Zanthoxylum bungeanum from the Rutaceae family, Bashan Sesamin has also been found in Chinese herbal medicines such as Zanthoxylum bungeanum, Cuscuta sinensis, and Cinnamomum camphora.
Although these plants all contain sesamin, their content is not as high as that of sesame seeds of the flax family. Sesame seeds contain about 0.5% to 1.0% lignans, the most important of which is sesamin, which accounts for about 50% of the total lignan compounds.
【English name】: Sesamin
【CAS Number】: CAS 607-80-7
【Botanical Source】: Sesamum indicum DC.
【Part Used】: Seed
【Appearance】: Fine Grey White to white crystal powder
【Specifications】: Sesamin 10%, 50%, 60%, 80%, 90%, 98% by HPLC
【Extraction Method】:
The separation and extraction methods of sesamin are mainly divided into two categories: one is to use organic solvents such as methanol, ether, etc. to directly extract sesamin from sesame oil, and then recrystallize and purify it; the other is to use low-pressure distillation of sesame oil, and then perform the distillate Molecular distillation, resin adsorption and other treatments. With the gradual deepening of research on sesamin, the requirements for the purity, production methods and product safety of sesamin are also getting higher and higher. The international community tends to adopt the second type of method and carry out preliminary physical treatment of sesame oil. to avoid contamination from organic solvents.
【Variety differences】:
The sesamin content of sesame seeds from different origins varies greatly. Comparing 42 types of cracked sesame seeds from China, Mexico, Colombia, Vietnam, Afghanistan and other places, it was found that the sesamin content in sesame oil ranged from 0.07% to 0.61%, with an average value of 0.36%. The lowest sesamin content was in the black seed sample with an oil content of 44.5%, while the highest sesamin content was in the white seed sample with an oil content of 55.1%. Among the sesame seeds growing on the same plant, the sesame seeds growing at the bottom contain the lowest sesamin content. On the contrary, the sesame seeds growing near the upper part have a higher sesamin content. These research results suggest that if sesamin is extracted, not only the variety, but also the influence of origin and growth period should be noted when selecting materials.
【Function】:
(1) Antioxidant effect:
Sesamin can remove excessive peroxides, hydroxyl free radicals, and organic free radicals in the body. The production and elimination of oxygen free radicals in the human body are in relative balance. If this balance is broken, many diseases will follow. Come. Studies have found that sesamin can increase the activity of free radical scavenging enzymes, inhibit oxidative stress reactions, reduce the generation of oxygen free radicals, and play a protective role in target organs. In in vitro antioxidant experiments, it was found that sesamin has good antioxidant capacity against DPPH free radicals, hydroxyl free radicals, superoxide anion free radicals and ABTS free radicals, and is close to the antioxidant performance of the common antioxidant VC. A better antioxidant.
(2) Anti-inflammatory effect:
Inflammation is defined as a series of defensive responses of body tissues with vascular systems to damaging factors. Inflammation can affect physiological activities such as cell proliferation and metabolism, leading to pathological changes in human tissues. Inflammation also often causes abnormalities in the number and function of osteoclasts, leading to excessive bone resorption and leading to the occurrence of many inflammatory osteolysis diseases, including rheumatoid arthritis, infectious osteolysis, aseptic loosening of joint prostheses, and periodontal disease. Yan et al. Studies have found that sesamin can inhibit osteoclast differentiation and bone resorption, reduce the production of pro-inflammatory cytokines, inhibit osteoclast differentiation, and reduce LPS-induced osteolysis. The specific mechanism may be that sesamin inhibits ERK. and NF-κB signaling pathway inhibit osteoclast differentiation and specific gene expression. Therefore, sesamin may be a potential drug for the treatment of inflammatory osteolysis.
(3) Cholesterol-lowering effect: Increased serum triglycerides and cholesterol are important factors in inducing atherosclerosis and cardiovascular and cerebrovascular diseases. In experiments on the effects of sesamin on blood lipids, blood sugar, and vascular remodeling in rats fed with high fat and high sugar, it was found that sesamin has a hypolipidemic effect, and its mechanism is related to sesamin increasing lipase activity, increasing fat metabolism, and reducing fat deposition. In a clinical trial of sesamin applied to people with hypercholesterolemia, it was found that the total serum cholesterol of the sesamin group decreased by an average of 8.5%, the low-density lipoprotein cholesterol (LDL-C) content decreased by an average of 14%, and the high-density lipoprotein cholesterol level decreased by an average of 14%. (HDL-C) increases by an average of 4%, the effect is close to that of anti-lipid drugs and is safe and has no side effects.
(4) Protect the liver
The metabolism of sesamin occurs mainly in the liver. Sesamin can regulate the activity of alcohol and fat metabolic enzymes, promote ethanol metabolism, and promote fatty acid beta oxidation, thereby reducing the damage of ethanol to the liver and the accumulation of fat in the liver.
(5) Antihypertensive effect
Sesamin can increase the concentration of NO in human venous endothelial cells and inhibit the concentration of ET-1 in endothelial cells, thereby inhibiting and regulating the increase in blood pressure [23]. In addition, sesamin can significantly improve hemodynamics in rats with renal hypertension, and its mechanism may be related to its anti-oxidation, increased myocardial NO and decreased ET-1.
COA:
How to choose sesamin?
1. Ingredients are clearly labeled
Check whether the sesamin content of the product ingredients is clearly marked. According to the regulations of the Food and Drug Administration of the Ministry of Health and Welfare, sesamin is different from sesame extract. Only when the sesamin concentration reaches more than 97% can it be called sesamin; if the sesamin concentration is less than 97%, it can be called sesamin. Belongs to sesame extract.
2. Adequate intake of sesamin
Follow the advice of your doctor or nutritionist or evaluate your own situation to consume adequate amounts of sesamin; the Food and Drug Administration stipulates that the daily consumption limit of sesamin is 15 mg.
3. Combined with compound ingredients
In addition to supplementing enough sesamin, if it can be combined with relaxing and sleep-aiding compound ingredients, the overall effect can be comprehensively improved, such as: GABA, tryptophan, vitamins (vitamin B6, B12 and vitamin D), plant extracts (asparagus extract) , chamomile extract), magnesium and calcium, etc.
4. The product has an inspection report, which ensures peace of mind
Before purchasing "Sesamin" products, you can first confirm whether there is a product-related inspection report, which should include safe and undetected test results such as heavy metals, plasticizers, and pesticide residues to ensure the quality and safety of the product.
When is the best time to take sesamin? Should you take sesamin before going to bed?
Since sesamin is a fat-soluble substance, the best time to take sesamin is after meals for better absorption. If you choose a compound sesamin product and want to improve the sleep-aiding effect, it is recommended to consume it 1 hour before going to bed.
Contraindications and side effects of sesamin
People allergic to sesame: People allergic to sesame or nut foods should avoid taking sesamin.
Pregnant or breastfeeding women: Please consult a physician before consumption.
Taking steroids and hypolipidemic drugs: Sesamin can lower blood lipids, so those who are taking steroids, hypolipidemic drugs or other cholesterol-lowering drugs should consult a doctor before use.
Anticoagulant-related drugs: Sesamin may affect platelet aggregation and coagulation, so those who are taking anticoagulant drugs or antiplatelet drugs should consult a doctor before use.
Drug interactions: Since sesamin can improve liver metabolism, long-term drug users should consult a doctor before using sesamin to avoid possible drug interactions.
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