Product Description

Ferulic acid contains reactive groups such as phenolic hydroxyl, carboxyl, olefinic bonds, and aromatic rings, making it a recognized natural antioxidant. Its physiological functions include free radical scavenging, antithrombosis, anti-atherosclerosis, antibacterial and anti-inflammatory effects, prevention of hypertension and heart disease, and enhancement of sperm motility. Therefore, it is widely used in medicine, food, and cosmetics.

However, due to its poor stability, ferulic acid is easily oxidized during storage and use, limiting the application and effectiveness of some of its important physiological functions. Therefore, in recent years, ferulic acid molecules have often been modified in some form to obtain more stable ferulic acid derivatives. Nyaradzo T. L. Chigorimbo-Murefu et al. studied the synthesis of esters from ferulic acid and natural compounds catalyzed by lipases. The results showed that *Candida albicans* lipase could perform transesterification reactions of ferulic acid vinyl derivatives and steroids, and that some of the synthesized compounds exhibited higher antioxidant activity than the precursor ferulic acid. Xin Jiaying, Zheng Yan, Zhao Guanli, and others first synthesized ethyl ferulic acid from ferulic acid and ethanol, and then reacted ethyl ferulic acid with vitamin E to obtain VE ferulic ester. VE ferulic ester is a compound formed by the esterification of ferulic acid with the 6-hydroxyl group of the β-chromone ring of α-tocopherol. Because it loses the free hydroxyl group, it does not possess the antioxidant activity of vitamin E and is relatively stable in air. It protects the 6-hydroxyl group of α-tocopherol, increasing the stability of α-tocopherol during storage and transportation. Simultaneously, it retains many physiological activities of ferulic acid, overcoming the disadvantage of its short alkane chain limiting its application in the oil and fat industry. Zhang Hui et al. modified ferulic acid with water-soluble chitosan, finding that chitosan enhances the activity of ferulic acid, and that FA-COS exhibits higher cytotoxic activity than ferulic acid.

The synthesis methods for ferulic ester derivatives include chemical synthesis, microbial transformation, and enzymatic biocatalysis. Enzymatic catalysis is considered a promising biotechnology due to its mild conditions, low byproduct rate, simple process, mild environment, high reaction selectivity, and easy product purification. Currently, ferulic acid glycoesters are mainly synthesized domestically through chemical methods. While chemical methods offer high conversion rates, they are complex, the products are difficult to separate, and produce numerous toxic byproducts, making continuous industrial production challenging. Research on enzymatic synthesis of ferulic acid glycoesters has not yet been reported.

Ethyl ferulic acid is a ferulic acid ester derivative with significantly enhanced lipid solubility compared to ferulic acid. In cosmetics, it possesses anti-free radical, antioxidant, microcirculation-promoting, skin-beautifying, and protective properties.

What are the benefits?

1. Antioxidant Effects

Effectively scavenges reactive oxygen species such as oxygen free radicals, hydroxyl free radicals, and nitrosamines, reducing oxidative stress damage to cells, protecting cell membrane lipids from oxidative attack, and delaying cell aging.

2. Cardiovascular Protection

Inhibits platelet aggregation, reduces the risk of thrombosis, and improves blood circulation.

Regulates blood lipid levels, assisting in the prevention of atherosclerosis and ischemic cardiovascular and cerebrovascular diseases.

Scavenges oxygen free radicals, protects vascular endothelial function, and enhances heart health.

3. Anti-inflammatory and Immunomodulatory Effects

Inhibits the release of inflammatory factors (such as TNF-α, IL-1β, and IL-6), alleviating inflammatory responses, and has potential therapeutic value for inflammatory-related diseases such as acute lung injury and acute respiratory distress syndrome (ARDS).

4. Liver Protection

Antagonizes chemical liver damage (such as liver damage caused by drugs or toxins), alleviates liver ischemia-reperfusion injury and immune-mediated liver injury, and has a significant liver-protective effect.

5. Antibacterial and Anti-infective Effects

Inhibits pathogens such as Staphylococcus aureus, reducing the risk of infection.

6. Skin Care

In cosmetics, it is used for moisturizing, anti-wrinkle, and UV protection, promoting skin cell regeneration and delaying skin aging.

It inhibits tyrosinase activity, reduces melanin production, and has a whitening effect.

Application directions

Ethyl ferulic acid has wide applications in multiple fields due to its unique physicochemical properties and biological activity. The main application areas are as follows:

1. Pharmaceutical Field

Cardiovascular and Cerebrovascular Disease Treatment: Inhibits platelet aggregation, reduces the risk of thrombosis, and improves blood circulation, used to treat diseases such as atherosclerosis and myocardial ischemia.
Anti-inflammatory and Immunomodulatory Effects: Inhibits the release of inflammatory factors (such as TNF-α and IL-6), alleviates inflammatory responses, and has potential therapeutic value for inflammatory diseases such as acute lung injury and arthritis.
Liver Protection: Antagonizes chemical liver injury, hepatic ischemia-reperfusion injury, and immune-mediated liver injury, exhibiting hepatoprotective effects.
Neuroprotection: In models of neurodegenerative diseases such as retinopathy and Alzheimer's disease, it demonstrates the ability to protect nerve cells from oxidative damage and neurotoxicity.

2. Cosmetics Field

Anti-aging: Scavenges free radicals, inhibits lipid peroxidation, promotes collagen synthesis, reduces wrinkles and fine lines, and delays skin aging.
Whitening and Spot-Fading: Inhibits tyrosinase activity, blocks the melanin production pathway, reduces age spots, freckles, and sun-induced pigmentation, and improves uneven skin tone.
Sunscreen: Absorbs ultraviolet rays with wavelengths of 290-330nm, reducing UV damage to the skin and preventing photoaging.
Anti-inflammatory and Soothing: Relieves skin redness, itching, and other inflammatory symptoms, promotes skin repair, and enhances the skin barrier function.

3. Food Industry

Natural Antioxidant: Effectively inhibits oil oxidation, prevents food rancidity, extends shelf life, and enhances food aroma.
Preservative: Inhibits pathogens such as Staphylococcus aureus, reduces the risk of food spoilage, and can replace some synthetic preservatives.

4. Scientific Research

Analytical Standard: Used as a standard for high-performance liquid chromatography (HPLC) analysis to quantitatively detect the content of ferulic acid and its derivatives, assisting in drug development and quality control.

Company introduction and certificates obtained

Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014, mainly supplying herbal extracts, functional cosmetic raw materials, organic products, etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.

Certificates

Our packaging

1KG/Aluminium bags , 25kg/barrel

Storage: Store in a cool, dry, clean place away from moisture and direct light.

We also have special packaging for special products, such as: retinal - cold chain transportation; deoxyarbutin - vacuum transportation

Packing & shipping

Our team

We have a professional R&D team and sales team, which not only ensure product quality, but also ensure a good cooperation experience for customers in the pre-sale, in-sale and after-sale processes. Our sales team has been trained in professional product knowledge, and can respond and solve every problem in cooperation in a timely manner

Team