Product Description
Dihydroberberine possesses physical properties including a density of 1.4 ± 0.1 g/cm³, a boiling point of 557.8 ± 50.0°C (760 mmHg), and a melting point of 223-224°C (decomposition). Its chemical characteristics include a LogP of 5.09, a hydrophobic parameter XlogP of 3.5, 25 heavy atoms, and a molecular polar surface area of 40.16.
Bioactivity studies show that dihydroberberine exerts anti-inflammatory, anti-atherosclerotic, lipid-lowering, and anti-tumor effects by inhibiting hERG channels and reducing Hsp90 expression. Its research areas include cancer, cardiovascular diseases, and inflammation/immunity-related fields, primarily acting on the HSP signaling pathway and potassium channel transmembrane transport mechanisms.
What are the benefits?
Dihydroberberine, a derivative of berberine, possesses various biological activities, primarily manifested in the following aspects:
1. Regulation of Glucose Metabolism
It can enhance insulin sensitivity, promote cellular glucose uptake and utilization, and inhibit hepatic gluconeogenesis, thereby lowering blood glucose levels and playing a role in improving insulin resistance and assisting in blood glucose control.
2. Improvement of Lipid Metabolism
It promotes browning of white adipose tissue, increases brown adipose tissue content, and enhances energy expenditure and thermogenesis; simultaneously, it inhibits the expression of adipogenesis-related genes, reducing fat deposition, which is helpful for weight management and improving lipid metabolism disorders.
3. Anti-inflammatory and Antioxidant Effects
It inhibits inflammatory signaling pathways (such as NF-κB, AP-1, etc.), reduces the release of pro-inflammatory cytokines (such as TNF-α, IL-6, etc.), and alleviates inflammatory responses; at the same time, it reduces oxidative damage by regulating oxidative stress-related pathways.
4. Cardiovascular Protection
It inhibits the formation of atherosclerotic plaques, reduces vascular inflammation and oxidative damage, helps improve vascular endothelial function, and has certain potential benefits in preventing cardiovascular diseases.
5. Maintaining Gut Health
It has antibacterial properties, which can inhibit the growth of pathogenic bacteria in the gut (such as Shigella and Escherichia coli), and alleviate symptoms of intestinal infection and diarrhea; at the same time, it regulates the balance of gut microbiota, promotes the growth of beneficial bacteria, and maintains the intestinal barrier function.
Application directions
Dihydroberberine, a derivative of berberine, exhibits application potential in multiple fields due to its higher bioavailability and stronger bioactivity, primarily including the following:
1. Metabolic Health
- Glucose Regulation: It can stimulate insulin receptor expression, enhance insulin sensitivity, promote cellular glucose uptake, and lower blood glucose levels, making it suitable for glycemic management in patients with prediabetes or type 2 diabetes.
- Lipid Metabolism Regulation: It promotes browning of white adipose tissue, increases brown adipose tissue content, inhibits the expression of adipogenesis genes, and reduces fat deposition, contributing to weight management and improvement of obesity-related metabolic disorders.
- Liver Metabolic Protection: It can upregulate the expression of liver-specific microRNA (mir-122), inhibit lipid synthesis and oxidative stress, and has potential for prevention and treatment of metabolic dysfunction-associated fatty liver disease (MASLD).
2. Cardiovascular Health
- Anti-Atherosclerosis: By inhibiting inflammatory responses and reducing the formation and fragility of atherosclerotic plaques, it reduces the risk of cardiovascular disease.
- Cholesterol Metabolism Regulation: Downregulates low-density lipoprotein cholesterol (LDL-C) levels and increases high-density lipoprotein cholesterol (HDL-C) levels, improving blood lipid profile.
3. Gut Health Area
- Anti-inflammatory and Gut Barrier Protection: Can alleviate intestinal inflammation such as ulcerative colitis, promote the expression of intestinal wall protective proteins, restore intestinal barrier function, and regulate gut microbiota balance.
- Gut Metabolic Regulation: Improves the gut microenvironment by influencing gut microbial metabolism, increasing short-chain fatty acid production.
4. Immunomodulatory Area
- Possesses anti-inflammatory and immunomodulatory effects, can inhibit the expression of pro-inflammatory cytokines, regulate immune cell activity, and may have adjunctive therapeutic value for certain autoimmune diseases or inflammation-related diseases.
Company introduction and certificates obtained
Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014, mainly supplying herbal extracts, functional cosmetic raw materials, organic products, etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.
Our packaging
1KG/Aluminium bags , 25kg/barrel
Storage: Store in a cool, dry, clean place away from moisture and direct light.
We also have special packaging for special products, such as: retinal - cold chain transportation; deoxyarbutin - vacuum transportation
Our team
We have a professional R&D team and sales team, which not only ensure product quality, but also ensure a good cooperation experience for customers in the pre-sale, in-sale and after-sale processes. Our sales team has been trained in professional product knowledge, and can respond and solve every problem in cooperation in a timely manner
The payment methods we support are: T/T, VISA, XTransfer, Master Card, Western Union, Alibaba Payment, e-Checking, Online Bank Payment
We support shipping by sea, air, DHL, FedEx, TNT, UPS, EMS, SF
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