7-Dehydrocholesterol

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of 7-dehydrocholesterol in China. With abundant experience, we warmly welcome you to wholesale bulk 7-dehydrocholesterol for sale here from our factory. Quality products and reasonable price are available.

7-Dehydrocholesterol is a common chemical substance, which appears as off-white crystalline powder or light yellow crystalline powder. Purity is an important indicator of its quality. The dry basis purity is required to be at least 90%, which ensures the stability and purity of its chemical properties.
In terms of specific rotation, the measured value of 7-dehydrocholesterol is between -108° and -120°, or in the range of -105° to -115°. This indicator reflects the symmetry and optical rotation of its molecular structure. The melting point is the transition temperature from solid to liquid. The melting point of 7-dehydrocholesterol is usually between 147°C and 151°C, which is also a clear sign of its physical state.
In terms of light absorption characteristics, its absorbance is required to be less than or equal to 0.15, which indicates that its light absorption capacity at a specific wavelength is low and the degree of light absorption is within an acceptable range. At the same time, the drying loss is the mass loss of the compound during the drying process. The drying loss of 7-dehydrocholesterol should be controlled within 7% to ensure its stability.
Finally, the content of 7-dehydrocholesterol is generally required to be 95% or above, and for some high-purity products, the content may reach 97%, which is directly related to its effectiveness and efficacy in practical applications. In general, the above indicators jointly ensure the quality and applicability of 7-dehydrocholesterol.

1) Take 5g of cholesterol and add it to 40ml of acetyl chloride, reflux at 100°C for 8h, and react to generate cholesterol acetate. The purity of cholesterol acetate generated by the reaction was determined by the internal standard method to be 94%, and the yield was 90%.

2) Take 5g of cholesterol acetate and dissolve it in 70ml of cyclohexanone, shake it at room temperature, and heat it to 50°C. Take 0.3g of selenium dioxide and add it to the reaction solution in batches, and add it in 30min. React at 80°C for 8h, cool it to room temperature, and then cool it with 3°C water. Crystals precipitate, filter it, and vacuum dry it at 50°C for 6h. The purity of 7-carbonyl cholesterol acetate obtained by testing is 86%, and the yield is 65%.

3) Take 5g of 7-carbonyl cholesterol acetate and 8g of p-toluenesulfonyl hydrazide and dissolve them in 50ml of anhydrous ethanol, stir at room temperature and monitor it by thin layer chromatography, stop the reaction after 15h, and concentrate to obtain the product 7-p-toluenesulfonyl hydrazone cholesterol acetate. The purity was 96% and the yield was 98%.

4,5) Take 5g of 7-p-methylbenzenesulfonylhydrazone cholesterol acetate and dissolve it in 50ml of chlorobenzene. Add 0.4g of lithium amide in batches at 100°C and stir for 5h. Cool to room temperature, wash with 10ml of glacial acetic acid until weakly acidic, and then wash with deionized water until neutral. The concentrated product obtained 7-dehydrocholesterol as a pale yellow solid. The purity of 7-dehydrocholesterol was 57% and the yield was 75%.

YTBIO mainly supplies 7-Dehydrocholesterol etc. The company was established in 2014 and has many years of R&D and production experience. We are committed to the research and development, production and sales of raw materials for the 21st century health industry. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA,etc. We always maintain the highest requirements for product quality.

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