Berberine Hcl Powder

Berberine hydrochloride(Berberine HCL Powder), also known as berberine, is one of the isoquinoline alkaloids, which can be extracted from various plants such as coptis. The product can effectively fight against a variety of bacteria. When the concentration is high, it can kill bacteria, and when the concentration is low, it can inhibit bacterial activity. Especially for gram-negative and positive bacteria, it has a relatively strong inhibitory effect on typhoid bacillus and meningococcus.

Berberine hydrochloride has long been used clinically as a heat-clearing, detoxifying and antibacterial drug. It is often used to treat diseases such as bacillary dysentery, acute gastroenteritis, chronic cholecystitis, conjunctivitis, and suppurative otitis media, all of which have significant effects. Berberine hydrochloride is an isoquinoline alkaloid that exists in many plants from 4 families and 10 genera including the Berberidaceae family. Berberine can precipitate yellow needle-like crystals from ether. Berberine is a quaternary ammonium alkaloid, and the solubility of its salts in water is relatively small, for example, the hydrochloride is 1:500 and the sulfate is 1:30.

Professional Berberine hcl manufacturer, YTBIO supplies 97% Berberine hcl powder. The products we supply have been factory tested to ensure product quality, and all our products are produced in our own factory. While ensuring product quality, we can also provide Competitive prices, as Berberine hcl factory we can provide ready-made products at any time, ensuring timely delivery. YTBIO product quality is stable and reliable, with complete qualification certifications and various product specifications to meet the needs of different customers. Professional cooperation and professional team provide you with the most valuable products and services.

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Antioxidant effect

Under normal circumstances, the body maintains a balance between antioxidants and pro-oxidants. Oxidative stress is a harmful process that may be an important mediator of damage to cellular structures, thereby inducing various disease states such as cardiovascular disease, cancer, neurological diseases, and diabetes. Overproduction of reactive oxygen species (ROS), most commonly through overstimulation of NADPH by cytokines or through the mitochondrial electron transport chain and xanthine oxidase, can lead to oxidative stress. Experiments have shown that berberine metabolites and berberine show excellent -OH scavenging activity, and their effects are roughly equivalent to the powerful antioxidant vitamin C. The increase in SOD (superoxide dismutase) activity and the decrease in MDA (a marker of lipid peroxidation) levels can be monitored by administering berberine to diabetic model rats. Further results showed that the scavenging activity of berberine is closely related to its ferrous ion chelating activity, and the C-9 hydroxyl group of berberine is an essential part.

Cardiovascular effects

Berberine plays a pivotal role in the treatment of cardiovascular diseases and has an extremely wide range of applications. Berberine achieves the purpose of anti-arrhythmia by reducing the incidence of premature ventricular contractions and inhibiting the occurrence of ventricular tachycardia. Second, dyslipidemia is a major risk factor for cardiovascular disease and is characterized by increased levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL), and decreased levels of high-density lipoprotein (HDL), whereas berberine The stability of these indicators can be maintained extremely well. Long-term hyperlipidemia is an important cause of atherosclerotic plaque formation. It has been reported that berberine affects LDL receptors in liver cells to reduce human serum cholesterol levels in hepatocytes. Not only that, berberine has positive inotropic effects and has been used to treat congestive heart failure .

Endocrine effects

Diabetes mellitus (DM) is a metabolic disorder characterized by an increase in blood glucose levels (hyperglycemia) resulting from the inability of pancreatic B cells to produce sufficient insulin, or the loss of effective target tissue responses to insulin. The hypoglycemic effects of berberine were discovered incidentally in the 1980s when treating diabetic patients with diarrhea.

Many studies show that berberine lowers blood sugar through the following mechanisms:

Inhibits mitochondrial glucose oxidation and stimulates glycolysis, subsequently increasing glucose metabolism;

Reduced ATP levels by inhibiting mitochondrial function in the liver;

Inhibits the activity of DPP 4, a ubiquitous serine protease, thereby cleaving certain peptides that increase insulin levels in the setting of hyperglycemia.

Berberine has beneficial effects on improving insulin resistance and glucose utilization in tissues by reducing lipids (especially triglycerides) and plasma free fatty acid levels.

Antibacterial effect

Berberine hydrochloride is usually taken orally in clinical practice to treat mild intestinal infections. The chloride of berberine hydrochloride can effectively inhibit Staphylococcus aureus and Enterococcus faecalis. Berberine hydrochloride also has a strong inhibitory effect on Shigella dysentery, Salmonella, etc., and can be used to treat bacillary dysentery. Helicobacter pylori (HP) infection is the main cause of peptic ulcer. Studies have found that berberine hydrochloride can inhibit HP proliferation and reduce the toxic effects of HP infection on cells. Some studies have also shown that by inhibiting the growth and respiration of HP, it inhibits the oxidative decarboxylation process of glucose and its metabolic intermediate product pyruvate, reducing the number of pili and reducing the ability of bacteria to adhere to cells, thereby killing bacteria.

Anti-inflammatory

Some articles have shown that berberine hydrochloride can increase the number of beneficial bacterial genera in the intestine, such as Blautia and allobaculum. These bacterial genera have the function of producing short-chain fatty acids (SCFA), and SCFA can regulate intestinal pH, anti-inflammatory, and regulate Human metabolism and immunity. There are also studies showing that berberine hydrochloride itself has strong anti-inflammatory and immunomodulatory effects, can reduce intestinal mucosal damage, such as mucosal damage caused by non-steroidal anti-inflammatory drugs and chronic stress, and can also reduce the production of inflammatory transmitters in the body. Express. Therefore, berberine hydrochloride can regulate the balance of bacterial flora and reduce mucosal damage, thereby achieving the treatment of UC.

Berberine hydrochloride and non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome mainly characterized by fat accumulation in liver cells. Studies have shown that although the mechanism of NAFLD is unclear, it is mainly related to insulin resistance, oxidative stress, inflammatory imbalance, and lipid metabolism disorders. Through rat modeling experiments, it was concluded that berberine hydrochloride can significantly alleviate liver tissue steatosis, reduce oxidative stress levels, reduce inflammatory cell infiltration, reduce NAS scores, and reduce ALT, AST, TC and LDL-C levels. It reduces the levels of TNF-α, IL-6, and IL-1β in liver tissue, increases the expression of Nrf2 mRNA in rat liver tissue, and increases the expression of Nrf2 in the nucleus of rat liver tissue. It is confirmed that berberine hydrochloride can alleviate NAFLD and reduce the inflammatory state, which may be related to increasing the nuclear expression of Nrf2 and reducing the level of oxidative stress, providing a basis for clinical prevention and treatment of NAFLD.

Berberine hydrochloride and cholecystitis

Chronic cholecystitis is a chronic inflammatory disease, mostly caused by chronic bacterial infection, chemical damage, stone stimulation, and repeated attacks of acute cholecystitis. Berberine is the main active ingredient in coptis. In addition to its well-known antibacterial effect, berberine also has anti-platelet aggregation effects and can improve the blood supply of the gallbladder mucosa. Previous studies have found that TNF-α levels in the serum of patients with chronic cholecystitis are significantly higher than those of healthy volunteers, and TNF-α levels can be significantly reduced after anti-inflammatory treatment. LEP can regulate the body's inflammatory response and oxidative stress response, and can activate the NF-κB pathway to participate in the inflammatory response. Research by Tang Jun et al. shows that berberine hydrochloride tablets combined with anistrisulfide tablets can improve clinical symptoms and reduce TNF-α and LEP levels in the treatment of chronic cholecystitis in elderly patients. Its application in the treatment of chronic cholecystitis has clinical significance.

Because of its outstanding antibacterial performance, the product is widely used in the pharmaceutical industry, mainly for the treatment of intestinal infections caused by Shigella, otitis media, gastroenteritis and other diseases. Medical research in recent years has shown that Berberine HCL powder also has a certain effect in combating arrhythmia.

          Applied in the pharmaceutical field

(1) Oral adverse reactions were less, including occasional nausea, vomiting, rash and drug fever, which disappeared immediately after drug withdrawal.

(2) Intravenous injection or infusion can cause vasodilation, blood pressure drop, cardiac depression and other reactions, and even death in severe cases, as syndrome.

A small number of people have mild abdominal or stomach discomfort, constipation or diarrhea.

Specification

YTBIO mainly supplies Berberine HCL powder, etc. The company was established in 2014 and has many years of experience in R&D and production. We are committed to the R&D, production and sales of raw materials for the health industry in the 21st century. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA etc. We always maintain the highest demands on product quality.

Our packing method is 1KG/Aluminium bags, 25kg/drum

For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin

Our team is professional, and our business team has undergone strict and professional product training. To ensure that our customers have a good cooperation experience and all questions during the cooperation process can be answered in a timely manner.

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