Luteolin

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of luteolin in China. With abundant experience, we warmly welcome you to wholesale bulk luteolin for sale here from our factory. Quality products and reasonable price are available.

Luteolin, mostly in the form of glycosides, exists in many plants. These plants have higher content in whole-leaf cyanus, pepper, wild chrysanthemum, honeysuckle, and perilla. It has antitussive and expectorant effects. According to the latest research, respiratory symptoms such as cough, sputum, and wheezing are all related to chronic airway inflammation. For example, bronchial asthma, chronic obstructive pulmonary disease, chronic pharyngitis, allergic rhinitis, etc., which cause cough, sputum, and wheezing, are all considered to be related to local inflammatory infiltration. The presence of inflammation makes the immune response of the airway chaotic, and patients often have increased airway reactivity. The means of treatment should first eliminate the chronic inflammatory infiltration of the airway. Glucocorticoids are often used to eliminate airway inflammation. However, glucocorticoids have many side effects and should not be used for a long time. Studies have shown that luteolin inhibits macrophage phosphorylation, inhibits the activity of transcription factor NF-kB, and can inhibit lipopolysaccharide (LPS)-induced macrophage production of cytokines IL-6 and TNF-a. In addition, studies have also shown that luteolin can inhibit the formation of uric acid and promote the excretion of uric acid. [2-3] The latter two cytokines play a very important role in the inflammatory mechanism and are sensitive indicators of the degree of inflammation. Luteolin can also increase IFN-γ, reduce specific Ig-E, and reduce the infiltration of eosinophils. In addition, in addition to its anti-inflammatory and anti-allergic effects, luteolin also has the characteristics of inhibiting PDE, anti-SARS, and HIV viruses. The reason is that it inhibits the activity of the SARS virus pre-S protein, thereby preventing it from entering the host cell. It is used to treat chronic cough caused by COPD, bronchial asthma, chronic pharyngitis, allergic rhinitis, etc.

Luteolin is a flavonoid compound that has a variety of health benefits, mainly including
Anti-inflammatory effect: Luteolin can effectively inhibit the production of inflammatory mediators, such as tumor necrosis factor-α and interleukins, thereby reducing inflammatory responses.
Antioxidant capacity: As a powerful antioxidant, luteolin can scavenge free radicals in the body, reduce oxidative stress, and help prevent cell damage and aging.
Cardiovascular protection: Luteolin helps lower blood pressure, improve cardiovascular function, and reduce cholesterol levels, thereby reducing the risk of cardiovascular disease.
Improved blood sugar control: Luteolin affects glucose metabolism through multiple mechanisms, including inhibiting glycogenolysis and promoting insulin secretion, which helps improve blood sugar control.
Antiviral properties: Luteolin can inhibit the replication of certain viruses, thereby playing a role in fighting viral infections.
Antibacterial effect: Luteolin has an inhibitory effect on a variety of bacteria, fungi and parasites, and can be used to treat certain infectious diseases.
Skin protection: Luteolin can reverse skin aging and prevent skin cancer by blocking MMP-1 expression.
Effect on testosterone: Luteolin may reduce the conversion of androgens to estrogens by blocking the aromatase enzyme or act as a testosterone enhancer.

Anti-inflammatory
It is believed that the anti-inflammatory activity of luteolin is related to inhibiting the production of nitric oxide (NO) and other inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and inhibiting protein network It is related to the phosphorylation of amino acids and gene expression mediated by nuclear transcription factor KB (NF-KB).
Anti-allergic
Luteolin can inhibit the immunoglobulin E (IgE)-mediated release of allergic response transmitters produced by human mast cells, including histamine, leukotrienes, prostaglandin D2, and monocyte-macrophage colony-stimulating factor. The effect may be related to the inhibition of Ca2+ influx and protein kinase C (PKC) translocation activation.
Anti-inflammatory demyelinating diseases
Luteolin can dose-dependently protect oligodendrocytes against oxidative damage induced by hydrogen peroxide in vitro, strongly inhibit the phagocytosis of myelin by macrophages, significantly reduce the production of cellular reactive oxygen species, and reduce the expression of iNOS protein. , significantly reduced NO levels produced by macrophages at low doses.
Anti-fibrosis
Luteolin can reduce the degree of liver fibrosis, reduce the contents of hydroxyproline (HYP), malondialdehyde (MDA) and the expression of type I procollagen mRNA in liver tissue, and can inhibit the expression of hepatic stellate cells (HSC) in vitro. Proliferation and collagen synthesis. It can also improve the histopathological changes of pulmonary fibrosis caused by bleomycin, reduce the lung weight index, significantly reduce the increase of MDA and HYP, and inhibit the expression of transforming growth factor-β1 (TGF-β1) mRNA in lung tissue. , can inhibit the proliferation of human embryonic lung fibroblasts and promote their apoptosis in vitro.
Lower uric acid (anti-uric acid high)
As a natural flavonoid, luteolin has the characteristic of inhibiting the activity of xanthine oxidase, thus inhibiting the production of uric acid. In addition, experiments have shown that luteolin has a significant effect when the dose is 100mg.kg-1. to promote uric acid excretion.
Antifertility and hormonal effects
Luteolin has significant dose-dependent anti-implantation activity. After oral administration, it can significantly increase the weight and diameter of the uterus, the thickness of the endometrium and the height of its epithelial cells. It has an estrogen-like effect when used alone, but it has an estrogen-like effect when used alone. Estradiol has been shown to have anti-estrogenic effects when used concomitantly.
Effect on blood vessels
Luteolin can inhibit vascular endothelial growth factor (VEGF)-induced angiogenesis in rabbit corneas in vivo; it can inhibit tumor growth and vascularization in mouse xenograft tumor models; it can inhibit VEGF-induced human umbilical vein endothelial cells (HUVECs) in vitro. survival and proliferation. It can significantly inhibit the proliferation and DNA synthesis of vascular smooth muscle cells induced by platelet-derived growth factor-BB (PDGF-BB), and can block the cell cycle in the G1 phase. It can concentration-dependently reduce the tension of phenylephrine precontracted blood vessels, antagonize vasoconstriction caused by high potassium, and has arterial relaxation effect, and its vasodilatory effect is endothelium-independent. Its mechanism of action is related to direct inhibition of voltage-dependent calcium channels, It is related to receptor-operated calcium channels, intracellular calcium release, and activation of potassium channels, but not to α and β receptors.
other
Luteolin can inhibit a variety of bacteria and viruses, such as Staphylococcus aureus, Escherichia coli, herpes simplex virus, polio virus, Coxsackie B3 virus, etc. It can inhibit the activity of HIV-1 integrase and has potential anti-HIV effects. Luteolin can bind to the S2 protein of severe acute respiratory syndrome (SARS) coronavirus, thereby inhibiting the virus from entering host cells. Luteolin also has anti-Leishmania donovani effects, inhibiting the growth of Leishmania donovani by inhibiting its topoisomerase I and topoisomerase II. In addition, luteolin also has immunomodulatory and blood pressure lowering effects.

YTBIO mainly supplies Luteolin etc. The company was established in 2014 and has many years of R&D and production experience. We are committed to the research and development, production and sales of raw materials for the 21st century health industry. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA,etc. We always maintain the highest requirements for product quality.

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