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What is Loquat leaf extract?
Loquat leaf extract is the active substance of the dry leaf extract of loquat, a plant of the Rosaceae family. The active ingredients are volatile oils, triterpenoids, sesquiterpenoids, flavonoids, polyphenols, organic acids, etc., and have pharmacological activities such as anti-inflammatory and antitussive, hypoglycemic, antiviral. Loquat leaf is the dry leaf of loquat, a plant of the Rosaceae family. Loquat leaf extractIt is also known as worry-free fan, loquat leaf, Ba leaf, and Luju leaf. It is native to the Yangtze River Basin in my country and has a cultivation history of more than 2,000 years. It has high fresh food, processing, medicinal and ornamental value, and is valued by many countries in the world.
What are the benefits of loquat leaf extract?
1. Antibacterial effect Loquat leaf ethyl acetate extract and ethanol extract have inhibitory effects on Staphylococcus aureus, Staphylococcus albus, hemolytic Streptococcus, pneumococcus, catarrhalis, etc. Oleanolic acid has varying degrees of antibacterial effects on Staphylococcus aureus, hemolytic Streptococcus, Escherichia coli, Shigella freundii, Salmonella typhi, Salmonella choleraesuis, etc.
2. Effects on the respiratory system: Amygdalin is decomposed into hydrocyanic acid and benzaldehyde by gastric acid or amygdalin. After absorption, it inhibits cytochrome oxidase, inhibits the oxidative metabolism of the common carotid body and reflexively deepens breathing. It has a sedative effect on the respiratory center, calms respiratory movements and achieves the effect of relieving cough and asthma. Loquat leaf decoction and its ethyl acetate extract have antiasthmatic and expectorant effects. Saponins have the effect of causing bronchial mucosa secretion and have an expectorant effect when taken orally. Caffeic acid has antitussive and expectorant effects.
3. Hypoglycemic effect. Triterpene acids and sesquiterpene compounds isolated from the methanol extract of loquat leaves have obvious hypoglycemic effects on diabetic mice. The mechanism of action may be to stimulate pancreatic B cells and increase the release level of insulin. , thereby achieving the effect of lowering blood sugar.
4. Liver-protecting and lipid-lowering loquat leaves. The oleanolic acid in loquat leaves has liver-protecting and detoxifying effects, and has a significant protective effect on acute and chronic hepatitis damage caused by CCl4. It significantly reduces the activities of alanine aminotransferase and aspartate aminotransferase, and can Prevent the occurrence of experimental cirrhosis.
5. Immunomodulatory effects: Cyclophosphamide (Cy) was used to induce mouse immunosuppression model, and carbon clearance test, hemolytic plaque test, dinitrofluorobenzene (DNFB)-induced delayed hypersensitivity reaction and T lymphocyte subtype were used. Group determination was conducted to observe the effects of loquat leaf triterpenic acid (TAL) on non-specific immunity, humoral immunity and cellular immunity in immunocompromised mice. The results show that TAL has good immunomodulatory effects.
6. Other effects Ursolic acid has stabilizing and cooling effects. Camphor is a local redness-inducing drug that has local stimulating and cardiotonic effects. Often used to treat chilblains. The amygdalin contained in it has a certain analgesic effect.
Chemical composition
Currently, the effective components isolated from loquat leaves mainly include volatile oils, triterpenoids, sesquiterpenoids, flavonoids, polyphenols, organic acids, etc.
1. Volatile oils The main components of volatile oils are nerolidol and farnesol, as well as pinene, camphene, myrcene, para-cymene linalool and its oxides.
2. Triterpenoids There are more than a dozen triterpenoids in loquat leaf extracts, with ursane and oleanane pentacyclic triterpenoids being the most common. Ju Jianhua et al. isolated 6 triterpenoids from the n-butanol extract of loquat leaves, which were identified as oleanolic acid, 2α-hydroxyoleanolic acid, ursolic acid, 2α-hydroxyursolic acid, selmol acid and rosic acid. Ursolic acid, 2α-hydroxyursolic acid, potentilla acid, oleanolic acid, 3-cis-p-coumaroyl potentilla acid, 3-trans-p-coumaroyl potentilla acid, 3-O-cis-caffeoyl potentilla acid, 3-O-trans-p-coumaroyl potentilla acid, maslic acid, 3β, 6α, 19α-trihydroxyursul-12-ene-28-acid and other polyhydroxyursulane derivatives were isolated from the chloroform extract of loquat leaves.
3. Sesquiterpenes Sesquiterpenes are mainly sesquiterpenes and monocyclic sesquiterpenes. DeTommasi et al. also isolated 4 ionone glycosides from loquat leaves.
4. Flavonoids The aglycones of flavonoids are mainly kaempferol and quercetin. The glycosides are composed of 1 to 3 monosaccharides, the most common of which are glucose, rhamnose, galactose, and arabinose, and the connection position is mostly 3-position. In addition, acetylated flavonoid glycosides were also found. The loquat leaves were extracted with dichloromethane, ethyl acetate, and butanol in turn. The ethyl acetate component was separated and purified by various chromatographic separations, and the structures of three compounds were determined, namely kaempferol-3-O-α-L-(2", 4"-di-E-p-coumaryl) rhamnoside, kaempferol-3-O-α-L-(2", 4"-di-Z-p-coumaryl) rhamnoside, and kaempferol-3-O-α-L-(2", 4"-di-E-feruloyl) rhamnoside.
5. Polyphenols contain a variety of polyphenol compounds, whose parent nuclei are flavonoids and flavan-3-ols, mainly including Chorogenicacid, (-)epicatechin, Procyanidin B-2, Cinchonain Ia, Procyanidinoligomer, etc.
6. Organic acids contain organic acids such as tartaric acid, citric acid and malic acid.
Extraction process
The crushed loquat leaves are refluxed with ethanol to obtain an extract-like extract, and the ethanol is recovered. The extract is fully washed with water and dried to obtain a dry extract. The dry extract is dissolved with ethanol and decolorized. After the ethanol is recovered, the decolorized liquid is added with water to precipitate a large amount of precipitation. The pH value is adjusted to 2-2.5, the precipitate is separated and collected, and washed with water until neutral, and vacuum dried to obtain a crude extract whose main component is ursolic acid.
Company Introduction And Certificates Obtained
YTBIO mainly supplies Loquat Leaf Extract etc. The company was established in 2014 and has many years of R&D and production experience. We are committed to the research and development, production and sales of raw materials for the 21st century health industry. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA,etc. We always maintain the highest requirements for product quality.
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