What is Fisetin?

Fisetin (fisetin, FIT), extracted from Toxicodendronsylvestre (Sieb.etZucc.) O.Kuntze, a sycamore tree. Because of the special structure of the ortho-diphenol hydroxyl group on the B ring, fisetin has strong pharmacological effects, such as anti-virus Chemicalbook, treatment of jaundice virus hepatitis; inhibition of cell apoptosis, human melanoma, anti-angiogenesis, nerve Protective, anticancer and other pharmacological activities. Although the drug fisetin has significant effects in the prevention and treatment of diseases, its low water solubility (solubility less than 1 mg/mL), chemical instability, low lipid solubility and dissolution rate, and rapid metabolism are limited by its properties. Its pharmaceutical preparations and clinical applications.

Test report

ITEM	STANDARD	TEST RESULT	TEST METHORD
Fisetin	≥98.0%	98.40%	HPLC
Physical & Chemical
Appearance	Light yellow fine powder	Complies	Visual
Odor & Taste	Characteristic	Characteristic	Organoleptic
Particle Size	98% through 80mesh	Complies	USP<786>
Extraction Solvent	Alcohol	Complies	------
Bulk Density	45-60g/100mL	Complies	USP<616>
Loss on drying	≤5.0%	3.25%	USP <731>
Ash	≤5.0%	1.05%	USP <281>
Solvents Residue	Meet USP standard	Complies	USP <476>
Pesticide Residue	Negative	Complies	USP <561>
Heavy Metal
Total Heavy Metals	≤10ppm	Complies	ICP-MS
As	≤2.0ppm	0.51ppm	ICP-MS
Pb	≤1.0ppm	0.36ppm	ICP-MS
Cd	≤1.0ppm	0.25ppm	ICP-MS
Hg	≤0.5ppm	0.02ppm	ICP-MS
Microbiological Test
Total Plate Count	≤1,000cfu/g	<100cfu/g	AOAC
Mold and Yeast	≤100cfu/g	<20cfu/g	AOAC
E.Coli	Negative	Complies	AOAC
Salmonella	Negative	Complies	AOAC
Conclusion	Conform with specification,Non-irradiation, Allergen Free, BSE/TSE Free
Storage	Store in cool and dry places. Keep away from strong light and heat
Packing	By 25kgs/Drum, inner by double plastic bag
Shelf Life	24 months under the above condition,and in it’s original package

What are the benefits of Fisetin?

1. Inhibition of prostaglandins: It has an inhibitory effect on the formation of prostatic cord in fibroblasts of 3T3 mice transformed by methylcholanthrene, and the median effective inhibitory concentration (ID50) is 42.0UM.

2. Enzyme inhibition: It has inhibitory effect on the whole sugar reductase of rat eye lens, and the half effective inhibitory concentration is 10-6M

3. Antispasmodic: The antispasmodic effect of acetylcholine is 166% of that of papaverine in the small intestine of mice.

4. A group of Japanese and American researchers found through animal experiments that fisetin in vegetables and fruits can help improve memory.

Application of Fisetin

1. Applied in the field of health care products, it is a nourishing food that is beneficial to the brain.

2. Applied in the field of medicine, it can be used to treat coronary heart disease with better curative effect.

3. Applied in the field of beauty, it has the functions of whitening, freckle removal, anti-wrinkle and skin cell activation.

Fisetin

Company introduction and certificates obtained

Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014, mainly supplying herbal extracts, functional cosmetic raw materials, organic products, etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.

Certificate