What Is Betulinic Acid Powder?

Betulinic acid is a pentacyclic triterpenoid compound that exists widely in nature. It was first isolated from the bark of Rhamnaceae evergreen plants growing in East Africa, but the main source is extraction and purification from birch bark. In recent years, scientific research has found that BA is a very valuable natural product. BA plays an important role in the body's anti-oxidative damage and immune regulation process. It is a class of potential drug lead compounds and has great value for the development of new drugs.
Chemical name 3β-hydroxy-lup-20(29)-ene-28-oic acid, molecular formula C30H48O3, molecular weight 456.71, CAS number 472-15-1, boiling point 550.0±33.0 °C (Predicted), acidity coefficient (pKa) 4.61 ±0.70(Predicted), density 1.065±0.06 g/cm3(Predicted).

What are the benefits?

1. Anti-inflammatory effect
Most pentacyclic triterpenoids have anti-inflammatory activity. Both betulin and betulinic acid have mild anti-inflammatory properties at higher concentrations, and their anti-inflammatory properties may depend on the inhibition of protein kinase C without involving any neurogenic inflammatory mechanism. Studies have also indicated that its activity is the result of interaction with glucocorticoid receptors.
The anti-inflammatory effect of betulinic acid has been verified in model systems in vivo and in vitro. Betulinic acid can inhibit the production of PGE2 and reduce inflammation. Studies have shown that it has an inhibitory effect on mouse inflammation induced by carrageenan, phorbol, and bryostatin 1, but has no inhibitory effect on arachidonic acid-induced inflammation and neurogenic inflammation models.
2. Antibacterial effect
It has been found that betulinic acid has a certain antibacterial effect, and can inhibit a variety of bacteria including Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis. However, studies have proved that its antibacterial activity is weak, which may be due to the fact that it belongs to the lupine pentacyclic triterpenoids, and its structure is similar to that of the hopane pentacyclic triterpenoids, and there are biosynthetic hopane pentacyclic triterpenes on the bacterial membrane. related to the substance. Based on the research on the antibacterial ability of existing betulinic acid, it has little potential as an antibacterial drug.
3. Antiviral effect
Betulinic acid has relatively prominent antiviral activity, especially anti-HIV activity, and has effective effects on anti-hepatitis C virus, anti-herpes simplex virus, anti-echo virus, and anti-influenza virus.
4. Anti-hyperlipidemia effect
Studies have found that betulinic acid and its derivatives can play an anti-hyperlipidemic effect by regulating adipokines, reducing lipid production, and reducing triacylglycerol and total cholesterol levels.
5. Anti-diabetic effect
Betulinic acid has shown good efficacy in the treatment of diabetes, mainly by inhibiting α-amylase and α-glucosidase to reduce the hydrolysis of polysaccharides and promote glycogen synthesis.
6. Antioxidative stress activity
BA has a protective effect on normal cells and the body, which has a certain relationship with anti-oxidative stress. For example, betulinic acid has a protective effect on ischemia-reperfusion injury of the brain, kidney and heart. BA has a protective effect on ischemia-reperfusion brain injury in mice by resisting oxidative stress, resisting nitrification stress and increasing blood flow.
7. Other diseases
Now some studies have found that betulinic acid has a certain improvement effect on senile dementia. Its protective effect is mainly through attenuating neurobehavioral and cognitive dysfunction, reducing pro-inflammatory cytokines in the hippocampus, and reducing oxidative and nitrosative reactions.
At the same time, it is also reported in the literature that betulinic acid has certain anxiolytic effects, and some anxiolytic drugs have already applied betulinic acid components. This may be related to the high fat solubility of betulinic acid, which can penetrate the brain barrier

Application direction

Betulinic acid powder has a very wide range of pharmacological effects, so it is widely used in the field of medicine and health products

Betulinic acid powder

Test Report

ITEM		STANDARD	TEST RESULT
Betulinic Acid		98.0%	98.36%
Physical & Chemical
Appearance		White or off white fine powder	Complies
Odor		Characteristic	Complies
Bulk Density		0.1-0.2g/ml	Complies
Sieve analysis		100% pass 40 mesh	Complies
Extract Solvents		Ethanol	Complies
Loss on Drying		≤5.0%	3.48%
Heavy Metal		<10ppm	Complies
As		<1ppm	Complies
Pb		<3ppm	Complies
Cd		<1ppm	Complies
Hg		<0.1ppm	Complies
Residual Solvents		Ethanol ≤5000 ppm	Complies
BSE/TSE		Free	Complies
GMO status		Free	Complies
Kosher Status		Yes	Complies
Microbiological Test
Total plate count		≤1,000cfu/g	100cfu/g
Mold and Yeast		≤100cfu/g	45cfu/g
Coliform		Negative	Negative
E.Coli		Negative	Negative
Salmonella		Negative	Negative
Conclusion	Conform with specification, Allergen Free, BSE/TSE Free.
Storage	Store in cool and dry places. Keep away from strong light and heat
Packing	By 25kgs/Drum, inner by double plastic bag
Shelf Life	24 months under the above condition,and in it's original package

Company introduction and certificates obtained

Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014, mainly supplying herbal extracts, functional cosmetic raw materials, organic products, etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.

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