Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of 1-deoxynojirimycin in China. With abundant experience, we warmly welcome you to wholesale bulk 1-deoxynojirimycin for sale here from our factory. Quality products and reasonable price are available.

What Is 1-Deoxynojirimycin?

1-Deoxynojirimycin, DNJ for short, is an alkaloid extracted from mulberry leaves and root bark, and also exists in other plants and microorganisms. This product is a powerful α-glucosidase inhibitor, which can effectively inhibit the conversion of sugar in the human body and reduce the sugar content in the blood. After entering the human body, it can inhibit the decomposition of starch and sugar by sucrase, maltase, α-glucosidase, and α-amylase in the human body, thereby blocking the absorption of sugar by the human body, inhibiting the rise in blood sugar, and achieving the effect of preventing and treating diabetes , It will not cause changes in dietary structure when used. In addition, DNJ can also inhibit virus activity to a certain extent.

Test Report

ITEM		STANDARD	TEST RESULT	TEST METHORD
DNJ		≥2.0%	2.11%	HPLC
Physical & Chemical
Appearance		Brown powder	Brown powder	Visual
Odor & Taste		Characteristic	Characteristic	Organoleptic
Particle Size		98% through 80 mesh	Complies	USP <786>
Loss on Drying		≤5.0%	4.55%	USP <731>
Ash		≤5.0%	3.30%	USP <281>
Solvents Residue		Meet USP standard	Complies	USP <476>
Pesticide Residue		Negative	Complies	USP <561>
Heavy Metal
As		≤1.0ppm	0.56ppm	ICP-MS
Pb		≤1.0ppm	0.36ppm	ICP-MS
Cd		≤1.0ppm	0.16ppm	ICP-MS
Hg		≤0.5ppm	0.10ppm	ICP-MS
Microbiological Test
Total Plate Count		≤1000cfu/g	<10cfu/g	AOAC
Mold and Yeast		≤100cfu/g	<10cfu/g	AOAC
Salmonella		Negative	Negative	AOAC
Escherichia coli		Negative	Negative	AOAC
Conclusion	Conform with specification,Non-irradiation, Allergen Free, BSE/TSE Free
Storage	Store in cool and dry places. Keep away from strong light and heat
Packing	By 25kgs/Drum, inner by double plastic bag
Shelf Life	24 months under the above condition,and in it's original package

What Are The Benefits?

Hypoglycemic effect of DNJ

DNJ is an effective inhibitor of α-glucosidase in all mammals, which can reduce postprandial hyperglycemia by reducing carbohydrate digestion and glucose absorption. Due to this property, DNJ can be used to alleviate diabetes and its complications, obesity and related disorders.

Hypoglycemic Mechanism

Triple pathway, common hypoglycemic

As a potent inhibitor of glucose metabolism enzymes (such as α-glucosidase, hexokinase, glucuronidase and glycogen phosphatase, etc.), DNJ can significantly delay the degradation process of polysaccharides and reduce the peak blood sugar after meals, Stabilize fasting blood sugar. In addition, DNJ also has the effect of increasing insulin sensitivity and improving insulin resistance.

Lower postprandial blood sugar

α-glucosidase is mainly distributed in the human small intestine and plays an important role in the decomposition of carbohydrates. They are responsible for breaking down oligosaccharides such as oligosaccharides in food into simple sugars such as glucose. These glucose enter the body through the intestinal wall, causing a sharp increase in the blood sugar concentration in the human body. DNJ is a natural and powerful α-glucosidase inhibitor, which can competitively bind α-glucosidase in the small intestine, and its affinity is stronger than that of oligosaccharides such as sucrose and maltose and α-glucosidase, reducing oligosaccharides and α-glucosidase. The probability of α-glucosidase binding, thereby inhibiting the decomposition of fructose into glucose, a large amount of sugar will not be absorbed and sent to the large intestine. Due to the action of DNJ, less glucose enters the blood, so the blood sugar level can be maintained at a healthy level.

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Stabilize fasting blood sugar

DNJ has the inhibitory activity of glycogen phosphorylase, which can slow down the process of liver glycogen degradation into glucose, thereby stabilizing fasting blood sugar. "Excess" glucose in the body is stored in the liver in the form of glycogen. Glycogen can be decomposed into glucose under the action of glycogen phosphorylase, and released into the blood to supply the needs of muscles and other organ activities. Glycogen is one of the main energy sources for physical activity. With the mutual transformation between glycogen and glucose, the blood sugar of normal people is in a dynamic balance. In diabetic patients, due to the disorder of glucose metabolism, too much glycogen will be decomposed into glucose, resulting in an abnormal increase in fasting blood glucose. DNJ can inhibit the activity of glycogen phosphorylase and prevent the increase of blood sugar level caused by the decomposition of excessive glycogen into glucose, so as to achieve the effect of stabilizing fasting blood sugar.

Improve insulin resistance

DNJ can improve the symptoms of insulin resistance by correcting lipid metabolism, slowing down glucose production and insulin sensitization. Insulin resistance refers to various reasons (mainly including genetic factors and obesity), which make insulin promote glucose uptake and utilization efficiency, and the body compensates for excessive secretion of insulin. Insulin resistance produces hyperinsulinemia in order to maintain the stability of blood sugar in the body. If the human body is in a state of insulin resistance for a long time, it will greatly increase the burden on the pancreas, which may lead to the failure of the pancreas to secrete insulin, and may develop diabetes. DNJ can improve the symptoms of insulin resistance by maintaining healthy blood sugar, correcting lipid metabolism, and increasing insulin sensitivity.

Application direction

It is widely used in the field of health products due to its effect of lowering blood sugar.

1-deoxynojirimycin

Mulberry Twig Alkaloids: Direct Renal Protective Effects in Chronic Kidney Disease

A study using an adenine-induced chronic kidney disease rat model evaluated the effects of mulberry twig alkaloids on renal function and renal pathological structure. Researchers measured renal function indicators such as serum creatinine and blood urea nitrogen, and observed the degree of renal tubular damage and interstitial fibrosis. Simultaneously, combined with transcriptomics and proteomics analysis, they systematically scanned molecular changes in renal tissue, focusing on fatty acid oxidation, mitochondrial function, and related signaling pathways. At the component level, the main active ingredient, deoxynojirimycin, was identified, and its transcriptional activation effect on PGC-1α was verified through cell experiments and a dual-luciferase reporter system.

1-deoxynojirimycin

The conclusions are as follows:

Mulberry twig alkaloids significantly improved renal function and reduced renal tubular damage and fibrosis in rats with chronic kidney disease without relying on hypoglycemic effects. The mechanism involves activating PGC-1α, restoring fatty acid oxidation capacity and mitochondrial homeostasis, reducing lipid deposition, and repairing renal tubular cell function from the source of energy metabolism. This study is the first to confirm that mulberry twig alkaloids have a direct nephroprotective effect, providing a new strategy for the energy metabolism treatment of chronic kidney disease and an important basis for the clinical repositioning of natural drugs.

1-deoxynojirimycin

Company introduction and certificates obtained

Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014, mainly supplying herbal extracts, functional cosmetic raw materials, organic products, etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.

certificate