Sericin Powder

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of sericin powder in China. With abundant experience, we warmly welcome you to wholesale bulk sericin powder for sale here from our factory. Quality products and reasonable price are available.

Sericin is a globular protein that coats the outer layer of silk, accounting for 20%-30% of the total protein in silkworm cocoons. Together with fibroin, it forms the structure of silk. Modern research confirms that sericin is rich in hydrophilic amino acids such as serine, aspartic acid, and glutamic acid, possessing excellent moisture-absorbing and moisturizing capabilities. It can be added to skincare products as a natural moisturizing factor. Furthermore, it can exert whitening and antioxidant effects by inhibiting tyrosinase activity and scavenging free radicals. It has wide applications in cosmetics.

YTBIO supplies sericin powder, made from natural silk through processes such as degumming, decolorization, enzymatic hydrolysis, ion exchange purification, and spray drying. It has good water solubility. Our products are suitable for the development of high-end skincare products, functional biomaterials, and oral beauty ingredients. We support sample testing and flexible MOQs. Please contact us anytime for the latest quote.

Fig. Overview of silk sericin (SS). Silkworm cocoons are composed of silk fibroin (SF) and SS. To obtain SS, silkworm cocoons need to be cut and disposed. The silkworm cocoons are then treated with different degumming methods including high temperature, acid/alkaline, ionic liquid, and enzyme treatment to obtain the solution of SS. SS-based biomaterials can be fabricated into different forms, including nanoparticle, hydrogel, scaffold, film, microneedle, etc., for food and biomedical applications. This is due to the intrinsic properties of SS, which include physicochemical and biological properties, i.e. mechanical property, antioxidant, pH-responsive, low (no) immunogenic, biocompatibility, and cell proliferation activity.

Sericin is a water-soluble globular protein, and its molecular weight in solution is affected by temperature, pH, etc. It consists of 18 kinds of amino acid residues, of which the main amino acid residues are serine (Ser), aspartic acid (Asp), and glycine (Gly), and their contents are about 33%, 20% and 14%, respectively. Amino acid residues contain a large number of strong polar groups such as hydroxyl, carboxyl, and amino groups, and the polar side chain amino acids in sericin account for more than 70%.

When the combined hydrogen ions and hydroxide ions on the protein reach equilibrium and the net charge on the protein is zero, the pH of the solution at this time is the isoelectric point of the protein. When the pH value of the solution is low, sericin exists in the form of positive ions, and when the pH value of the solution is high, sericin exists in the form of negative ions. Sericin is a globular protein, its polypeptide chain is tightly folded, the hydrophobic amino acid side chain is located inside the molecule, and the hydrophilic amino acid side chain is exposed to the water solvent outside, so the globular protein has good solubility in water solvent . However, the molecular weight of sericin has a great influence on its solubility. Small molecular sericin can dissolve in cold water, and large molecular sericin can dissolve in hot water. Sericin is a natural biopolymer with a large molecular weight, so the particle size of sericin is generally between 1 and 100nm, which belongs to the range of colloidal particles, so the sericin solution will also show dialysis, coagulation, gelation, etc. properties of colloidal solutions such as gelation and peptization.

1. Amphoteric properties and isoelectric point of sericin Sericin contains free shuttle groups and amino groups, which can interact to form bipolar ions and have amphoteric properties. In a solution with a lower pH value, sericin exists in the form of positive ions; in a solution with a higher pH value, sericin exists in the form of negative ions. The isoelectric point of sericin is: 3.8-4.5.
2. Colloidal properties of sericin Sericin is a polymer compound with a large molecular weight and a particle diameter of 1-100nm. Since the particle size is within the range of colloidal particles, it shows the unique characteristics of dialysis, coagulation, Gelling and peptizing properties.
3. Sericin denaturation When sericin molecules are affected by some external physical or chemical factors, their properties often change, but these changes do not involve changes in the primary structure, and the covalent bonds of the skin chains are not broken. A change in molecular conformation occurs, which causes a change in properties. Its main manifestations are changes in physical properties, chemical properties, and loss of biological activity. The most prominent performance is a decrease in solubility, which will greatly reduce its use value. The main factors causing sericin denaturation are temperature, pH value and organic solvent.
4. Swelling and dissolving of sericin Sericin is a kind of macromolecule, when it comes in contact with appropriate liquid, it will automatically absorb liquid and swell and become soft, and it can be dissolved in liquid after infinite swelling. In general, silk fibroin can only swell but not dissolve in water, but sericin can dissolve in hot water. This is the most important property of sericin, and it is also the basis for people to use water to make silk and degumming.

Moisturizing and humidity regulating function

Sericin is very similar to the natural moisturizing factors contained in the human body, so it not only moisturizes but also regulates the moisture of the skin, allowing the skin to maintain moisture and elasticity. At the same time, its hydrolyzate is also a natural antioxidant. The ability to inhibit oxidation is similar to that of VC.
The reason why sericin has excellent moisturizing and hygroscopic functions is determined by the molecular structure of sericin. The molecular conformation of sericin is a random coiled structure, and its polypeptide chain is loose and disordered, so that many hydrophilic groups on the polypeptide chain are located on the surface of the molecule's spatial structure, and these hydrophilic groups can transfer moisture to the human body. It binds to the stratum corneum of the epidermis to maintain appropriate moisture content in the skin, making the skin elastic, smooth and soft. Although glycerin also has good hygroscopic properties, it can easily clog skin pores when used in excessive amounts. Sericin does not have this disadvantage at all.

Anti-inflammatory effect on skin
Water-soluble sericin has obvious effects on some skin diseases and is a good medicine for treating skin inflammation. It can reduce inflammation and has a good effect on aging skin and weak elasticity.

sun protection
Silk fibroin is rich in tyrosine, tryptophan and phenylalanine, as is sericin. They can absorb ultraviolet rays and prevent ultraviolet rays from causing damage and aging to the skin. They are excellent sunscreen ingredients~

Inhibit skin melanin production
Adding 1% mass fraction of sericin can reduce the tyrosinase activity by more than half, and the melanin inhibition rate reaches 52. 39%. This is because the hydroxyamino acids (serine, threonine) in sericin are complexed with trace elements (copper, iron, etc.), which affects the normal performance of tyrosinase activity, thereby effectively inhibiting the formation of melanin, so it is used in skin care products. Adding an appropriate amount of sericin to cosmetics can keep the skin white.

Protecting and repairing hair
The structure of sericin is very similar to the keratin protein of hair, so sericin has a good affinity with hair, and its adsorption capacity to hair is also large.
When the hair is impregnated and adsorbed with sericin, the elasticity of the hair increases with the increase in the mass fraction of sericin. When the mass fraction of sericin is as low as 0.2% (a), the elasticity of the hair (63.45%) is increased by 8.62 times compared with the control sample. percentage points, when the mass fraction of sericin is 1.0% (e), its elasticity (86.79%) is 31.96 percentage points higher than that of the control sample. After the hair absorbs sericin, its strength also increases. Similarly, the increase in strength is positively correlated with the mass fraction of sericin.

1.Drug delivery carrier
Drug delivery systems mainly deliver active compounds such as drugs to specific sites through targeted molecules, control their release or stabilize their molecular state to achieve the desired biological activity. Sericin can be used as a vehicle to bind small molecule drugs because it is easy to bind charged molecules. In addition, sericin contains many amino acids with many modifiable sites and can be combined with drugs through chemical modification, so it can be used in the field of drug delivery.

2.Skin tissue repair materials
There have been many research reports on the application of sericin in skin tissue repair. For example, sericin hydrogel prepared by photo-cross-linking method can be used as a new wound dressing to repair full-thickness skin damage. Sericin hydrogel It can promote the effective regeneration of hair follicles and sebaceous glands, thereby promoting wound healing.

3. Bone tissue engineering repair materials
Bone tissue repair materials often require strong mechanical strength, and pure sericin is difficult to use directly due to its poor mechanical properties. However, due to its ability to promote cell proliferation, sericin has a positive effect on bone tissue repair. At the same time, sericin has a bionic mineralization function, which can induce the nucleation of hydroxyapatite (HA), and the prepared HA is deposited on the flexible sericin composite film. Another study showed that HA complex prepared by mineralization of sericin supported the survival of bone marrow stem cells more effectively than sericin alone, showing good cell adhesion, upregulation of alkaline phosphatase and other osteogenic markers. It was shown that sericin complex can induce osteogenic differentiation more effectively.

4. Nerve repair materials
It has been reported that nerve conduits prepared using sericin as raw material can be used as long-term implants for peripheral nerve regeneration. The conduits have mechanical strength that matches peripheral nerve tissue, support Schwann cell proliferation, and can upregulate snowflakes. Transcription of neurotrophic factors and nerve growth factors in Wanmann cells, this sericin-based conduit can be used for autologous nerve transplantation to repair damaged peripheral nerves.

Application direction

Cosmetics

Normal skin cutin needs to contain 10%-20% moisture to ensure the elasticity and plumpness of the skin. The natural moisturizing factor rich in sericin is a perfect ingredient that combines moisturizing and humidity control. Now it has been widely used in skin care products such as cleansing, lotion, lotion, and cream.

In the field of beauty, sericin has antioxidant and anti-UV activities and can be used as a cosmetic additive. Specifically, sericin can scavenge free radicals and ROS due to its special amino acid sequence, especially the large number of hydroxyl groups contained in serine and threonine, and further enhances its antioxidant properties by chelating trace elements such as copper, iron and zinc. . In addition, sericin contains a large amount of hydrophilic amino acids, so sericin has excellent hygroscopicity and can play a role similar to the natural moisturizing factor in the stratum corneum of human skin, allowing the skin to maintain appropriate moisture content, thereby making The skin is smooth and elastic. In addition, sericin has the characteristic of inhibiting tyrosinase activity and can prevent the formation of melanin in the skin.
Because sericin contains a variety of essential amino acids, adding water-soluble sericin to cosmetics can be easily absorbed by the skin.

Food field

The amino acids contained in sericin are not only essential amino acids for the human body, but 90% of them can be directly absorbed by the human body. Different amino acids correspond to different effects. At the same time, these two are also a nutritional factor that can improve memory and prevent dementia.

Company introduction and certificates obtained

Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014, mainly supplying herbal extracts, functional cosmetic raw materials, organic products, etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.

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