Dipotassium Glycyrrhizinate Powder

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of dipotassium glycyrrhizinate powder in China. With abundant experience, we warmly welcome you to wholesale bulk dipotassium glycyrrhizinate powder for sale here from our factory. Quality products and reasonable price are available.

Dipotassium glycyrrhizate powder is derived from licorice root, extracted with water, and then completely neutralized by adding potassium hydroxide or potassium carbonate. White or off-white powder, triterpene saponin that is easily soluble in water, soluble in ethanol, and insoluble in oils and fats.
Dipotassium glycyrrhizate is potassium glycyrrhizinate extracted from licorice root. It is a skin conditioner and a moisturizer that can soothe sensitivity, repair damage, resist inflammation and whiten. Clinical trials have shown that dipotassium glycyrrhizinate can also effectively deal with dermatitis. At the same time, dipotassium glycyrrhizinate is also a natural sweetener with anti-inflammatory, antiviral, hepatoprotective, detoxifying, and immune function enhancing effects. According to food additive standards, dipotassium glycyrrhizinate can be used as a sweetener in flour products.

Anti-inflammatory repair
Dipotassium Glycyrrhizinate Powder reduces and subsides inflammation by controlling the production of inflammatory factors, while repairing skin barrier damage caused by inflammation. The anti-inflammatory effect of 0.5% dipotassium glycyrrhizinate solution is equivalent to that of 0.1% dexamethasone without serious adverse reactions.

Soothing and anti-allergic
As a skin conditioner, dipotassium glycyrrhizinate is anti-inflammatory, anti-allergic, and antibacterial. It also has calming, soothing, and moisturizing effects. It has a good effect on relieving redness and itchiness of the skin and helps restore the skin. Barrier function, improve skin immunity.

Assisted whitening
Dipotassium glycyrrhizinate can form a self-defense barrier on the skin from the root to prevent and reduce skin problems such as tanning, spots, and acne. It can also whiten the skin and form a natural barrier against ultraviolet rays on the skin.

Moisturizing and repairing
Dipotassium glycyrrhizinate can inhibit the activity of hyaluronidase and protect hyaluronic acid, thereby improving skin moisture. I would like to ask an expert to speak out: Under normal circumstances, the dosage of dipotassium glycyrrhizinate is only 0.1-0.8%. SkinCeuticals Purple Rice Essence is added to 2%. Obviously, it is not used to soothe, but to "activate" Skin surges with hyaluronic acid."

Hormone face soothing
It can reduce the adverse reactions of withdrawal caused by hormones, relieve the pain of hormone recovery period, and accelerate the recovery of damaged skin. This effect has also been clinically recognized.

Gum Care Part Time Sweetener
Dipotassium glycyrrhizinate can be used as a health protector of oral soft tissue. Consistent use of toothpaste or mouthwash containing dipotassium glycyrrhizinate can effectively prevent oral soft tissue inflammation and repair mucosal damage. It is the best choice for caring for your gums. Toothpaste containing more than 0.2% dipotassium glycyrrhizinate can also play an oral antibacterial role.

In addition, the natural sweetener of dipotassium glycyrrhizinate can also act as a sweetener and flavoring agent in oral care products, replacing sodium saccharin to improve the safety of toothpaste.

Scalp itching and hair loss prevention
In hair care and hair care products, dipotassium glycyrrhizinate can reduce scalp irritation caused by surfactants and play a role in preventing itching and hair loss.

In addition, the core aglycyrrhizin of dipotassium glycyrrhizinate, glycyrrhetinic acid, can inhibit 5α-reductase and reduce excessive scalp oil secretion and subsequent hair loss caused by testosterone.

Antibacterial
The antibacterial effect of glycyrrhizinate was studied, and it was found that disodium glycyrrhizinate, dipotassium glycyrrhizinate, and diammonium glycyrrhizinate were effective against Staphylococcus aureus, Staphylococcus albus, Escherichia coli, and Shigella flexneri under in vitro experimental conditions. bacteria, Salmonella paratyphi type B and other bacteria have shown varying degrees of antibacterial effects.

Anti-inflammatory and soothing
Methods: An inflammation and allergy model was constructed using keratinocytes and a 3D recombinant human epidermal model to verify the anti-inflammatory and soothing effects of Yuhara hot spring water (HW) combined with dipotassium glycyrrhizinate (DG).

After treating keratinocytes with different concentrations of DG for 24 hours, the CCK-8 method was used to detect the activity of NHEK cells (primary human keratinocytes). The results are shown in Figure 2. The concentration of DG (dipotassium glycyrrhizinate) was 100 μmol/ L has no toxicity to NHEK cells.

The NF-κB (nuclear transcription factor-κB) pathway is a classic inflammatory pathway and cell signaling pathway, which plays a crucial role in the activation and expression of inflammatory factors and the regulation of the inflammatory process. As shown in Figure 3, adding 1% HW combined with 100 μmol/L DG inhibited the inflammatory factor complex-induced activation of NF-κB by 69.6% (P<0.05). Therefore, after adding the HW+DG complex, NHEK The NF-κB activation signal was effectively reduced, thereby reducing the degree of inflammatory response.

IL-1α and IL-6 play key positions in the overall inflammatory response of cells and skin. As shown in Figure 4b and 4c, compared with the control group, the levels of IL-1α (interleukin-1α) and IL-6 (interleukin-6) increased significantly after stimulation (P<0.05). Compared with the inflammation model, DG IL-1α and IL-6 in the NC group decreased by 58.8% and 57.2% respectively, while the HW combined with DG group significantly reduced the secretion of inflammatory factors in the NC group (control group) (P<0.05).

Activation of the capsaicin receptor (TRPV1) will promote the secretion of various neurogenic substances and inflammatory factors, aggravating itching and pain. As shown in Figure 5a, compared with the blank control group, the mRNA expression level of TRPV1 in the NC group stimulated by inflammatory factors increased significantly (P<0.05). Both DG and HW treatment alone can downregulate the expression of TRPV1, and HW combined with DG group effectively reduced the TRPV1 expression level by 3.9 times (P<0.05).

Prostaglandin E2 (PGE2) is a metabolite of the polyunsaturated fatty acid arachidonic acid and participates in a variety of biological reactions in the body. An appropriate amount of PGE2 can regulate the inflammatory response in the body and promote wound healing, while cyclooxygenase (COX -2) is the most important rate-limiting enzyme in the PGE2 synthesis process. As shown in Figure 5b, under the induction of the stimulating complex, the mRNA expression of COX-2 increased 6.88 times (P<0.05). After HW treatment, the expression level of COX-2 mRNA was slightly down-regulated, which was not significant, while the COX in the DG group The relative expression level of -2 mRNA decreased significantly (P<0.05). After HW combined with DG intervention, COX-2 mRNA expression was significantly down-regulated (P<0.05).

Conclusion: In the recombinant human epidermal model induced by inflammatory factor complex, HW combined with DG effectively reduced the secretion levels of interleukin 1α (IL-1α) and interleukin 6 (IL-6). In terms of allergy relief, HW combined with DG can significantly reduce the secretion level of vascular endothelial growth factor (VEGF) and down-regulate the expression of capsaicin receptor (TRPV1) and cyclooxygenase (COX-2) mRNA.

Used in the pharmaceutical industry: used for antitussive and expectorant, gastric ulcer, acute and chronic gastritis, eczema, skin pruritus, hepatitis, hyperlipidemia, conjunctivitis, and for the treatment of cancer and prevention of AIDS. It is mainly used for eye drops and stomatitis ointments.

Used in the cosmetics industry: Dipotassium Glycyrrhizinate Powder has a wide range of compatibility in cosmetics. It is often used with other active agents to accelerate the skin's absorption of them and increase efficiency.

Used in the food industry: it can be used as a potassium supplement, sweetener, preservative, and flavoring agent for sports drinks.

Daily chemical industry: can be used for toothpaste production.

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YTBIO mainly supplies Dipotassium Glycyrrhizinate Powder etc. The company was established in 2014 and has many years of R&D and production experience. We are committed to the research and development, production and sales of raw materials for the 21st century health industry. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA,etc. We always maintain the highest requirements for product quality.

Our packing method is 1KG/Aluminium bags, 25kg/drum

For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin

Our team is professional, and our business team has undergone strict and professional product training. To ensure that our customers have a good cooperation experience and all questions during the cooperation process can be answered in a timely manner.

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